Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition

Detalhes bibliográficos
Autor(a) principal: Spínola, Vítor
Data de Publicação: 2018
Outros Autores: Pinto, Joana, Castilho, Paula C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.13/3206
Resumo: Vaccinium cylindraceaeum (Azores blueberry) and V. padifolium (Madeira blueberry) are two Portuguese endemic species, which phytochemical composition and beneficial properties lack scientific validation. In this work, their potential in vitro inhibitory effects against key enzymes linked to type 2 diabetes and obesity and glycation of proteins were evaluated. Anthocyanins were predominant in fruits, while hydroxycinnamic acids (in particular 5-O-caffeoylquinic acid) and flavonoids were the main compounds in leaves. Vaccinium extracts showed effective inhibitions of glucosidases and glycation of proteins and mild activity towards α-amylase and pancreatic lipase (by comparison with reference compounds). Phenolic composition was strongly correlated with reported bioactivities. In fact, 5-O-caffeoylquinic can be considered one of the main hypoglycemic and anti-glycation agents of analysed extracts. Consumption of both Vaccinium species should be encouraged since berries could offer a dietary option in the prevention and control of diabetes and obesity, while leaves are good candidates for development of nutraceuticals.
id RCAP_b94efc75f30bb95ebf5ec1ea0e05cb71
oai_identifier_str oai:digituma.uma.pt:10400.13/3206
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic compositionVaccinium cylindraceumVaccinium padifoliumPolyphenolsDigestive enzymes inhibitionAnti-glycationAntioxidant activity.Faculdade de Ciências Exatas e da EngenhariaVaccinium cylindraceaeum (Azores blueberry) and V. padifolium (Madeira blueberry) are two Portuguese endemic species, which phytochemical composition and beneficial properties lack scientific validation. In this work, their potential in vitro inhibitory effects against key enzymes linked to type 2 diabetes and obesity and glycation of proteins were evaluated. Anthocyanins were predominant in fruits, while hydroxycinnamic acids (in particular 5-O-caffeoylquinic acid) and flavonoids were the main compounds in leaves. Vaccinium extracts showed effective inhibitions of glucosidases and glycation of proteins and mild activity towards α-amylase and pancreatic lipase (by comparison with reference compounds). Phenolic composition was strongly correlated with reported bioactivities. In fact, 5-O-caffeoylquinic can be considered one of the main hypoglycemic and anti-glycation agents of analysed extracts. Consumption of both Vaccinium species should be encouraged since berries could offer a dietary option in the prevention and control of diabetes and obesity, while leaves are good candidates for development of nutraceuticals.The authors are grateful to Cândida Dias from Flores Island (Azores archipelago), to Francisco Fernandes and José Carvalho from Madeira Botanical Garden and to Funchal Ecological Park for the supply and identification of plant material.International Society for Nutraceuticals and Functional Foods (ISNFF)DigitUMaSpínola, VítorPinto, JoanaCastilho, Paula C.2021-03-26T09:56:40Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/3206engSpínola, V., Pinto, J., & Castilho, P. C. (2018). Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition. Journal of Functional Foods, 40, 595-605. 10.1016/j.jff.2017.12.00210.1016/j.jff.2017.12.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-19T05:33:49Zoai:digituma.uma.pt:10400.13/3206Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:06:09.566512Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
title Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
spellingShingle Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
Spínola, Vítor
Vaccinium cylindraceum
Vaccinium padifolium
Polyphenols
Digestive enzymes inhibition
Anti-glycation
Antioxidant activity
.
Faculdade de Ciências Exatas e da Engenharia
title_short Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
title_full Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
title_fullStr Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
title_full_unstemmed Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
title_sort Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition
author Spínola, Vítor
author_facet Spínola, Vítor
Pinto, Joana
Castilho, Paula C.
author_role author
author2 Pinto, Joana
Castilho, Paula C.
author2_role author
author
dc.contributor.none.fl_str_mv DigitUMa
dc.contributor.author.fl_str_mv Spínola, Vítor
Pinto, Joana
Castilho, Paula C.
dc.subject.por.fl_str_mv Vaccinium cylindraceum
Vaccinium padifolium
Polyphenols
Digestive enzymes inhibition
Anti-glycation
Antioxidant activity
.
Faculdade de Ciências Exatas e da Engenharia
topic Vaccinium cylindraceum
Vaccinium padifolium
Polyphenols
Digestive enzymes inhibition
Anti-glycation
Antioxidant activity
.
Faculdade de Ciências Exatas e da Engenharia
description Vaccinium cylindraceaeum (Azores blueberry) and V. padifolium (Madeira blueberry) are two Portuguese endemic species, which phytochemical composition and beneficial properties lack scientific validation. In this work, their potential in vitro inhibitory effects against key enzymes linked to type 2 diabetes and obesity and glycation of proteins were evaluated. Anthocyanins were predominant in fruits, while hydroxycinnamic acids (in particular 5-O-caffeoylquinic acid) and flavonoids were the main compounds in leaves. Vaccinium extracts showed effective inhibitions of glucosidases and glycation of proteins and mild activity towards α-amylase and pancreatic lipase (by comparison with reference compounds). Phenolic composition was strongly correlated with reported bioactivities. In fact, 5-O-caffeoylquinic can be considered one of the main hypoglycemic and anti-glycation agents of analysed extracts. Consumption of both Vaccinium species should be encouraged since berries could offer a dietary option in the prevention and control of diabetes and obesity, while leaves are good candidates for development of nutraceuticals.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-03-26T09:56:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.13/3206
url http://hdl.handle.net/10400.13/3206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Spínola, V., Pinto, J., & Castilho, P. C. (2018). Hypoglycemic, anti-glycation and antioxidant in vitro properties of two Vaccinium species from Macaronesia: A relation to their phenolic composition. Journal of Functional Foods, 40, 595-605. 10.1016/j.jff.2017.12.002
10.1016/j.jff.2017.12.002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Society for Nutraceuticals and Functional Foods (ISNFF)
publisher.none.fl_str_mv International Society for Nutraceuticals and Functional Foods (ISNFF)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129932432932864

Registros relacionados