Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis

Detalhes bibliográficos
Autor(a) principal: Machado-Oliveira, Gisela
Data de Publicação: 2020
Outros Autores: Ramos, Cristiano, Marques, André R.A., Vieira, Otília V.
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/106542
Resumo: Our research is supported by national funds through FCT- Fundação para a Ciência e Tecnologia and by PROGRAMAS DE ATIVIDADES CONJUNTAS (PAC) grant numbers PTDC/MED-PAT/29395/2017 and N◦3/SAICT/2015. ARAM is supported by the CEECIND/01006/2017, funded by FCT.
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spelling Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosisatherosclerosiscardiovascular diseasessenescencesenescent organellesMedicine(all)SDG 3 - Good Health and Well-beingOur research is supported by national funds through FCT- Fundação para a Ciência e Tecnologia and by PROGRAMAS DE ATIVIDADES CONJUNTAS (PAC) grant numbers PTDC/MED-PAT/29395/2017 and N◦3/SAICT/2015. ARAM is supported by the CEECIND/01006/2017, funded by FCT.Atherosclerosis is an age-related disorder associated with long-term exposure to cardiovascular risk factors. The asymptomatic progression of atherosclerotic plaques leads to major cardiovascular diseases (CVD), including acute myocardial infarctions or cerebral ischemic strokes in some cases. Senescence, a biological process associated with progressive structural and functional deterioration of cells, tissues and organs, is intricately linked to age-related diseases. Cell senescence involves coordinated modifications in cellular compartments and has been demonstrated to contribute to different stages of atheroma development. Senescence-based therapeutic strategies are currently being pursued to treat and prevent CVD in humans in the near-future. In addition, distinct experimental settings allowed researchers to unravel potential approaches to regulate anti-apoptotic pathways, facilitate excessive senescent cell clearance and eventually reverse atherogenesis to improve cardiovascular function. However, a deeper knowledge is required to fully understand cellular senescence, to clarify senescence and atherogenesis intertwining, allowing researchers to establish more effective treatments and to reduce the cardiovascular disorders' burden. Here, we present an objective review of the key senescence-related alterations of the major intracellular organelles and analyze the role of relevant cell types for senescence and atherogenesis. In this context, we provide an updated analysis of therapeutic approaches, including clinically relevant experiments using senolytic drugs to counteract atherosclerosis.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNMachado-Oliveira, GiselaRamos, CristianoMarques, André R.A.Vieira, Otília V.2020-11-02T23:56:33Z2020-09-232020-09-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/106542eng2073-4409PURE: 26054834https://doi.org/10.3390/cells9102146info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:48:27Zoai:run.unl.pt:10362/106542Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:48:27Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
title Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
spellingShingle Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
Machado-Oliveira, Gisela
atherosclerosis
cardiovascular diseases
senescence
senescent organelles
Medicine(all)
SDG 3 - Good Health and Well-being
title_short Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
title_full Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
title_fullStr Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
title_full_unstemmed Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
title_sort Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
author Machado-Oliveira, Gisela
author_facet Machado-Oliveira, Gisela
Ramos, Cristiano
Marques, André R.A.
Vieira, Otília V.
author_role author
author2 Ramos, Cristiano
Marques, André R.A.
Vieira, Otília V.
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Machado-Oliveira, Gisela
Ramos, Cristiano
Marques, André R.A.
Vieira, Otília V.
dc.subject.por.fl_str_mv atherosclerosis
cardiovascular diseases
senescence
senescent organelles
Medicine(all)
SDG 3 - Good Health and Well-being
topic atherosclerosis
cardiovascular diseases
senescence
senescent organelles
Medicine(all)
SDG 3 - Good Health and Well-being
description Our research is supported by national funds through FCT- Fundação para a Ciência e Tecnologia and by PROGRAMAS DE ATIVIDADES CONJUNTAS (PAC) grant numbers PTDC/MED-PAT/29395/2017 and N◦3/SAICT/2015. ARAM is supported by the CEECIND/01006/2017, funded by FCT.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-02T23:56:33Z
2020-09-23
2020-09-23T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/106542
url http://hdl.handle.net/10362/106542
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4409
PURE: 26054834
https://doi.org/10.3390/cells9102146
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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