Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer

Detalhes bibliográficos
Autor(a) principal: Laranjo, Mafalda
Data de Publicação: 2020
Outros Autores: Aguiar, Márcia Campos, Pereira, Nelson A. M., Brites, Gonçalo, Nascimento, Bruno F. O., Brito, Ana F., Casalta-Lopes, João, Gonçalves, Ana Cristina, Sarmento-Ribeiro, Ana Bela, Piñeiro Gomez, Marta, Botelho, Maria Filomena, Melo, Teresa M. V. D. Pinho e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/93139
https://doi.org/10.1016/j.ejmech.2020.112468
Resumo: The discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging-guided photodynamic therapy. In addition to the high activity as PDT agent and absence of cytotoxicity per se, this molecule showed the ideal photophysical and photochemical properties. In vivo studies using a A375 melanoma mouse model, proved the extraordinary properties of this chlorin as a luminescent probe and the ability to impair tumor growth, making image guided treatment and follow up a possibility.
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spelling Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancerAnimal modelsBladder carcinomaLuminescence imagingMelanomaOesophageal carcinomaOptical imagingPhotodynamic therapyPhotosensitizersPt(II) chlorinsTheranosticsAntineoplastic AgentsCell Line, TumorCell ProliferationCoordination ComplexesDose-Response Relationship, DrugDrug Screening Assays, AntitumorEsophageal NeoplasmsFluorescent DyesHumansMelanomaMolecular StructurePlatinumPorphyrinsStructure-Activity RelationshipUrinary Bladder NeoplasmsOptical ImagingPhotochemotherapyThe discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging-guided photodynamic therapy. In addition to the high activity as PDT agent and absence of cytotoxicity per se, this molecule showed the ideal photophysical and photochemical properties. In vivo studies using a A375 melanoma mouse model, proved the extraordinary properties of this chlorin as a luminescent probe and the ability to impair tumor growth, making image guided treatment and follow up a possibility.Elsevier Masson2020-08-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/93139http://hdl.handle.net/10316/93139https://doi.org/10.1016/j.ejmech.2020.112468eng02235234https://www.sciencedirect.com/science/article/pii/S0223523420304396Laranjo, MafaldaAguiar, Márcia CamposPereira, Nelson A. M.Brites, GonçaloNascimento, Bruno F. O.Brito, Ana F.Casalta-Lopes, JoãoGonçalves, Ana CristinaSarmento-Ribeiro, Ana BelaPiñeiro Gomez, MartaBotelho, Maria FilomenaMelo, Teresa M. V. D. Pinho einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-10T11:05:50Zoai:estudogeral.uc.pt:10316/93139Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:12:07.243703Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
title Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
spellingShingle Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
Laranjo, Mafalda
Animal models
Bladder carcinoma
Luminescence imaging
Melanoma
Oesophageal carcinoma
Optical imaging
Photodynamic therapy
Photosensitizers
Pt(II) chlorins
Theranostics
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Coordination Complexes
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Esophageal Neoplasms
Fluorescent Dyes
Humans
Melanoma
Molecular Structure
Platinum
Porphyrins
Structure-Activity Relationship
Urinary Bladder Neoplasms
Optical Imaging
Photochemotherapy
title_short Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
title_full Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
title_fullStr Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
title_full_unstemmed Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
title_sort Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer
author Laranjo, Mafalda
author_facet Laranjo, Mafalda
Aguiar, Márcia Campos
Pereira, Nelson A. M.
Brites, Gonçalo
Nascimento, Bruno F. O.
Brito, Ana F.
Casalta-Lopes, João
Gonçalves, Ana Cristina
Sarmento-Ribeiro, Ana Bela
Piñeiro Gomez, Marta
Botelho, Maria Filomena
Melo, Teresa M. V. D. Pinho e
author_role author
author2 Aguiar, Márcia Campos
Pereira, Nelson A. M.
Brites, Gonçalo
Nascimento, Bruno F. O.
Brito, Ana F.
Casalta-Lopes, João
Gonçalves, Ana Cristina
Sarmento-Ribeiro, Ana Bela
Piñeiro Gomez, Marta
Botelho, Maria Filomena
Melo, Teresa M. V. D. Pinho e
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Laranjo, Mafalda
Aguiar, Márcia Campos
Pereira, Nelson A. M.
Brites, Gonçalo
Nascimento, Bruno F. O.
Brito, Ana F.
Casalta-Lopes, João
Gonçalves, Ana Cristina
Sarmento-Ribeiro, Ana Bela
Piñeiro Gomez, Marta
Botelho, Maria Filomena
Melo, Teresa M. V. D. Pinho e
dc.subject.por.fl_str_mv Animal models
Bladder carcinoma
Luminescence imaging
Melanoma
Oesophageal carcinoma
Optical imaging
Photodynamic therapy
Photosensitizers
Pt(II) chlorins
Theranostics
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Coordination Complexes
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Esophageal Neoplasms
Fluorescent Dyes
Humans
Melanoma
Molecular Structure
Platinum
Porphyrins
Structure-Activity Relationship
Urinary Bladder Neoplasms
Optical Imaging
Photochemotherapy
topic Animal models
Bladder carcinoma
Luminescence imaging
Melanoma
Oesophageal carcinoma
Optical imaging
Photodynamic therapy
Photosensitizers
Pt(II) chlorins
Theranostics
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Coordination Complexes
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Esophageal Neoplasms
Fluorescent Dyes
Humans
Melanoma
Molecular Structure
Platinum
Porphyrins
Structure-Activity Relationship
Urinary Bladder Neoplasms
Optical Imaging
Photochemotherapy
description The discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging-guided photodynamic therapy. In addition to the high activity as PDT agent and absence of cytotoxicity per se, this molecule showed the ideal photophysical and photochemical properties. In vivo studies using a A375 melanoma mouse model, proved the extraordinary properties of this chlorin as a luminescent probe and the ability to impair tumor growth, making image guided treatment and follow up a possibility.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/93139
http://hdl.handle.net/10316/93139
https://doi.org/10.1016/j.ejmech.2020.112468
url http://hdl.handle.net/10316/93139
https://doi.org/10.1016/j.ejmech.2020.112468
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 02235234
https://www.sciencedirect.com/science/article/pii/S0223523420304396
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Masson
publisher.none.fl_str_mv Elsevier Masson
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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