Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models

Detalhes bibliográficos
Autor(a) principal: Soto, Fernando
Data de Publicação: 2021
Outros Autores: Guimarães, Carlos F., Reis, R. L., Franco, Walfre, Rizvi, Imran, Demirci, Utkan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/71981
Resumo: Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.
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spelling Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer modelsBioengineeringExternally driven assemblyOrgan on a chipPersonalized medicineSelf-assemblyScience & TechnologyTissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.This work was supported by research funding provided by DoD grants (LC150650, W81XWH-16-1-0200) and (LC19029, W81XWH-20- 1-0746), NCI Center for Cancer Nano-technology Excellence for Trans lational Diagnostics (NCI– U54CA199075), NIH grant (R01 EB029805), the International Alliance for Cancer Early Detection (ACED) pilot award, and the Canary Center at Stanford for Cancer Early Detection Seed Award. F.S was supported by Stanford Molecular Imaging Scholars program, 5R25CA118681. (NIH T32 postdoctoral fellowship) and Schmidt Science Fellows. C.F.G acknowledges support from Fundaçao ˜ para a Ciˆencia e Tecnologia (Grant no. PD/BD/135253/2017), Fundaçao Luso-Americana para o Desenvolvimento (FLAD) and Stan ford RISE COVID-19 Crisis Response Faculty Seed Grant Program. I.R. acknowledges funding provided by the NC Translational and Clinical Sciences Institute (NCTraCS), supported by the National Center for Advancing Translational Sciences (NCATS, National Institutes of Healthh (NIH), through Grant Award Number UL1TR002489, and UNCNC State Joint BME Department Start-up Fund. F.S. and C.F.G. contributed equally to this work.ElsevierUniversidade do MinhoSoto, FernandoGuimarães, Carlos F.Reis, R. L.Franco, WalfreRizvi, ImranDemirci, Utkan2021-042021-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/71981engSoto F., Guimarães C. F., Reis R. L., Franco W., Rizvi I., Demirci U. Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models, Cancer Letters, Vol. 504, pp. 116-124, doi:10.1016/j.canlet.2021.01.023, 20210304-383510.1016/j.canlet.2021.01.02333577978https://www.sciencedirect.com/science/article/pii/S0304383521000471info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-13T01:26:30Zoai:repositorium.sdum.uminho.pt:1822/71981Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:42:41.754219Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
title Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
spellingShingle Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
Soto, Fernando
Bioengineering
Externally driven assembly
Organ on a chip
Personalized medicine
Self-assembly
Science & Technology
title_short Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
title_full Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
title_fullStr Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
title_full_unstemmed Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
title_sort Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models
author Soto, Fernando
author_facet Soto, Fernando
Guimarães, Carlos F.
Reis, R. L.
Franco, Walfre
Rizvi, Imran
Demirci, Utkan
author_role author
author2 Guimarães, Carlos F.
Reis, R. L.
Franco, Walfre
Rizvi, Imran
Demirci, Utkan
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Soto, Fernando
Guimarães, Carlos F.
Reis, R. L.
Franco, Walfre
Rizvi, Imran
Demirci, Utkan
dc.subject.por.fl_str_mv Bioengineering
Externally driven assembly
Organ on a chip
Personalized medicine
Self-assembly
Science & Technology
topic Bioengineering
Externally driven assembly
Organ on a chip
Personalized medicine
Self-assembly
Science & Technology
description Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
2021-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/71981
url https://hdl.handle.net/1822/71981
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Soto F., Guimarães C. F., Reis R. L., Franco W., Rizvi I., Demirci U. Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models, Cancer Letters, Vol. 504, pp. 116-124, doi:10.1016/j.canlet.2021.01.023, 2021
0304-3835
10.1016/j.canlet.2021.01.023
33577978
https://www.sciencedirect.com/science/article/pii/S0304383521000471
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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