Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors

Detalhes bibliográficos
Autor(a) principal: Teixeira-Gomes, Armanda
Data de Publicação: 2021
Outros Autores: Laffon, Blanca, Valdiglesias, Vanessa, Gostner, Johanna M., Felder, Thomas, Costa, Carla, Madureira, Joana, Fuchs, Dietmar, Teixeira, João Paulo, Costa, Solange
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8072
Resumo: (This article belongs to the Special Issue Tryptophan Metabolism in Health and Disease)
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spelling Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk FactorsCRP and IL-6Kyn/TrpPhe/TyrFrailtyModifiable Risk FactorsNeopterinNitriteOxi-Immune MarkersOxidative DNA DamageVitamin AVitamin E(This article belongs to the Special Issue Tryptophan Metabolism in Health and Disease)Ageing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxidative stress. Serum concentrations of vitamins A and E were also evaluated, as well as inflammatory biomarkers (CRP and IL-6) and oxidative DNA levels. A group of Portuguese older adults (≥65 years old) was engaged in this study and classified according to Fried's frailty phenotype. Significant increases in the inflammatory mediators (CRP and IL-6), neopterin levels, kynurenine to tryptophan ratio (Kyn/Trp), and phenylalanine to tyrosine ratio (Phe/Tyr), and significant decreases in Trp and Tyr concentrations were observed in the presence of frailty. IL-6, neopterin, and Kyn/Trp showed potential as predictable biomarkers of frailty syndrome. Several clinical parameters such as nutrition, dependency scales, and polypharmacy were related to frailty and, consequently, may influence the associations observed. Results obtained show a progressive immune activation and production of pro-inflammatory molecules in the presence of frailty, agreeing with the inflammageing model. Future research should include different dimensions of frailty, including psychological, social, biological, and environmental factors.ATG: J.M. and S.C. are supported by Fundação para a Ciência e Tecnologia (FCT-MCTES), and the European Social Fund, through Programa Operacional Capital Humano (POCH), under the grants SFRH/BD/121802/2016, SFRH/BPD/115112/2016 and SFRH/BPD/100948/2014, respectively. This research was supported by Ministerio de Ciencia e Innovación (PID2020-113788RB-I00) and Ministerio de Educación, Cultura y Deporte (BEAGAL18/00142, to V.V.)MDPIRepositório Científico do Instituto Nacional de SaúdeTeixeira-Gomes, ArmandaLaffon, BlancaValdiglesias, VanessaGostner, Johanna M.Felder, ThomasCosta, CarlaMadureira, JoanaFuchs, DietmarTeixeira, João PauloCosta, Solange2022-07-06T15:50:40Z2021-12-102021-12-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8072engAntioxidants (Basel). 2021 Dec 10;10(12):1975. doi: 10.3390/antiox101219752076-392110.3390/antiox10121975info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:24Zoai:repositorio.insa.pt:10400.18/8072Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:48.581499Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
title Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
spellingShingle Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
Teixeira-Gomes, Armanda
CRP and IL-6
Kyn/Trp
Phe/Tyr
Frailty
Modifiable Risk Factors
Neopterin
Nitrite
Oxi-Immune Markers
Oxidative DNA Damage
Vitamin A
Vitamin E
title_short Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
title_full Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
title_fullStr Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
title_full_unstemmed Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
title_sort Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
author Teixeira-Gomes, Armanda
author_facet Teixeira-Gomes, Armanda
Laffon, Blanca
Valdiglesias, Vanessa
Gostner, Johanna M.
Felder, Thomas
Costa, Carla
Madureira, Joana
Fuchs, Dietmar
Teixeira, João Paulo
Costa, Solange
author_role author
author2 Laffon, Blanca
Valdiglesias, Vanessa
Gostner, Johanna M.
Felder, Thomas
Costa, Carla
Madureira, Joana
Fuchs, Dietmar
Teixeira, João Paulo
Costa, Solange
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Teixeira-Gomes, Armanda
Laffon, Blanca
Valdiglesias, Vanessa
Gostner, Johanna M.
Felder, Thomas
Costa, Carla
Madureira, Joana
Fuchs, Dietmar
Teixeira, João Paulo
Costa, Solange
dc.subject.por.fl_str_mv CRP and IL-6
Kyn/Trp
Phe/Tyr
Frailty
Modifiable Risk Factors
Neopterin
Nitrite
Oxi-Immune Markers
Oxidative DNA Damage
Vitamin A
Vitamin E
topic CRP and IL-6
Kyn/Trp
Phe/Tyr
Frailty
Modifiable Risk Factors
Neopterin
Nitrite
Oxi-Immune Markers
Oxidative DNA Damage
Vitamin A
Vitamin E
description (This article belongs to the Special Issue Tryptophan Metabolism in Health and Disease)
publishDate 2021
dc.date.none.fl_str_mv 2021-12-10
2021-12-10T00:00:00Z
2022-07-06T15:50:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8072
url http://hdl.handle.net/10400.18/8072
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antioxidants (Basel). 2021 Dec 10;10(12):1975. doi: 10.3390/antiox10121975
2076-3921
10.3390/antiox10121975
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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