Atypical, non-standard functions of the microtubule associated Tau protein

• Autor(a) principal: Sotiropoulos, I.
• Data de Publicação: 2017
• Outros Autores: Galas, Marie-Christine, Silva, Joana Margarida Gonçalves Mota, Skoulakis, Efthimios, Wegmann, Susanne, Maina, Mahmoud Bukar, Blum, David, Sayas, Carmen Laura, Mandelkow, Eva-Maria, Sousa, Nuno, et. al.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/50175
• topic: Tau; Alzheimer’s disease; Neuronal function; Pathology; Nucleus; Dendrites; Synapse; Subcellular localization; Tau isoform; Ciências Médicas::Medicina Básica; Science & Technology

Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.