Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/150649 |
Resumo: | Funding Information: This work was funded by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant 2021). Publisher Copyright: © 2022 by the authors. |
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Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancerantimicrobialdrug deliveryhyperthermiamagneto-fluorescencemesoporous nanoparticlesopportunistic cancer-related bacteriaCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: This work was funded by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant 2021). Publisher Copyright: © 2022 by the authors.Cancer-related opportunistic bacterial infections are one major barrier for successful clinical therapies, often correlated to the production of genotoxic factors and higher cancer incidence. Although dual anticancer and antimicrobial therapies are a growing therapeutic fashion, they still fall short when it comes to specific delivery and local action in in vivo systems. Nanoparticles are seen as potential therapeutic vectors, be it by means of their intrinsic antibacterial properties and effective delivery capacity, or by means of their repeatedly reported modulation and maneuverability. Herein we report on the production of a biocompatible, antimicrobial magneto-fluorescent nanosystem (NANO3) for the delivery of a dual doxorubicin–ofloxacin formulation against cancer-related bacterial infections. The drug delivery capacity, rendered by its mesoporous silica matrix, is confirmed by the high loading capacity and stimuli-driven release of both drugs, with preference for tumor-like acidic media. The pH-dependent emission of its surface fluorescent SiQDs, provides an insight into NANO3 surface behavior and pore availability, with the SiQDs working as pore gates. Hyperthermia induces heat generation to febrile temperatures, doubling drug release. NANO3-loaded systems demonstrate significant antimicrobial activity, specifically after the application of hyperthermia conditions. NANO3 structure and antimicrobial properties confirm their potential use in a future dual anticancer and antimicrobial therapeutical vector, due to their drug loading capacity and their surface availability for further modification with bioactive, targeting species.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNMarcelo, Gonçalo A.Galhano, JoanaRobalo, Tiago T.Cruz, Maria MargaridaMarcos, María D.Martínez-Máñez, RamónDuarte, Maria PaulaCapelo-Martínez, José LuisLodeiro, CarlosOliveira, Elisabete2023-03-15T22:34:54Z2022-10-142022-10-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article21application/pdfhttp://hdl.handle.net/10362/150649eng1661-6596PURE: 55913551https://doi.org/10.3390/ijms232012287info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:47Zoai:run.unl.pt:10362/150649Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:14.301249Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
title |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
spellingShingle |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer Marcelo, Gonçalo A. antimicrobial drug delivery hyperthermia magneto-fluorescence mesoporous nanoparticles opportunistic cancer-related bacteria Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
title_short |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
title_full |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
title_fullStr |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
title_full_unstemmed |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
title_sort |
Magneto-Fluorescent Mesoporous Nanocarriers for the Dual-Delivery of Ofloxacin and Doxorubicin to Tackle Opportunistic Bacterial Infections in Colorectal Cancer |
author |
Marcelo, Gonçalo A. |
author_facet |
Marcelo, Gonçalo A. Galhano, Joana Robalo, Tiago T. Cruz, Maria Margarida Marcos, María D. Martínez-Máñez, Ramón Duarte, Maria Paula Capelo-Martínez, José Luis Lodeiro, Carlos Oliveira, Elisabete |
author_role |
author |
author2 |
Galhano, Joana Robalo, Tiago T. Cruz, Maria Margarida Marcos, María D. Martínez-Máñez, Ramón Duarte, Maria Paula Capelo-Martínez, José Luis Lodeiro, Carlos Oliveira, Elisabete |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química RUN |
dc.contributor.author.fl_str_mv |
Marcelo, Gonçalo A. Galhano, Joana Robalo, Tiago T. Cruz, Maria Margarida Marcos, María D. Martínez-Máñez, Ramón Duarte, Maria Paula Capelo-Martínez, José Luis Lodeiro, Carlos Oliveira, Elisabete |
dc.subject.por.fl_str_mv |
antimicrobial drug delivery hyperthermia magneto-fluorescence mesoporous nanoparticles opportunistic cancer-related bacteria Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
topic |
antimicrobial drug delivery hyperthermia magneto-fluorescence mesoporous nanoparticles opportunistic cancer-related bacteria Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
description |
Funding Information: This work was funded by the Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant 2021). Publisher Copyright: © 2022 by the authors. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-14 2022-10-14T00:00:00Z 2023-03-15T22:34:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/150649 |
url |
http://hdl.handle.net/10362/150649 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1661-6596 PURE: 55913551 https://doi.org/10.3390/ijms232012287 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
21 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138131853705216 |