Association between Elevated Iodine Intake and IQ among School Children in Portugal
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/145855 |
Resumo: | Funding Information: This project was funded through grants by the Public Health Initiatives Programme (PT06), financed by EEA Grants Financial Mechanism 2009–2014, and supported by FEDER through the operation POCI-01-0145-FEDER-007746 funded by the Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., within CINTESIS, R&D Unit (reference UIDP/4255/2020) and within the scope of the project RISE, Associated Laboratory (reference LA/P/0053/2020). DP and VCF also received individual funding from Fundação para a Ciência e a Tecnologia (SFRH/BPD/109158/2015 in the first case; SFRH/BPD/109153/2015, UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020 in the second case). |
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Association between Elevated Iodine Intake and IQ among School Children in Portugalcognitionexcessive iodineiodine-adequate populationrepresentative sampleschool agesFood ScienceNutrition and DieteticsFunding Information: This project was funded through grants by the Public Health Initiatives Programme (PT06), financed by EEA Grants Financial Mechanism 2009–2014, and supported by FEDER through the operation POCI-01-0145-FEDER-007746 funded by the Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., within CINTESIS, R&D Unit (reference UIDP/4255/2020) and within the scope of the project RISE, Associated Laboratory (reference LA/P/0053/2020). DP and VCF also received individual funding from Fundação para a Ciência e a Tecnologia (SFRH/BPD/109158/2015 in the first case; SFRH/BPD/109153/2015, UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020 in the second case).The goal of this work was to examine whether elevated iodine intake was associated with adverse effects on IQ among school-age children in Portugal. In a representative sample of children from the north of the country, IQ percentiles by age (assessed with Raven’s Colored Progressive Matrices) were dichotomized to <50 (“below-average” IQs) and ≥50. Morning urine iodine concentrations, corrected for creatinine, were dichotomized to <250 µg/g and ≥250 µg/g, according to the European Commission/Scientific Committee on Food’s tolerable upper level of daily iodine intake for young children. Data were examined with Chi-square tests, logistic regression, and GLM univariate analysis. The sample (N = 1965) was classified as generally iodine-adequate (median urinary iodine concentration = 129 µg/L; median iodine-to-creatinine ratio = 126 µg/g) according to the WHO’s criteria. A greater proportion of children in the ≥250 µg/g group had below-average IQs, compared to children with less than 250 µg/g (p = 0.037), despite a sizable (though non-significant) proportion of children in the less-than-250 µg/g group also presenting below-average IQs, at the bottom of the iodine distribution (<50 µg/g). The proportion of below-average IQs increased with increasingly elevated iodine concentrations (p = 0.047). The association remained significant after the adjustment for confounders, with the elevated iodine group showing increased odds of having below-average IQs when compared with the non-elevated iodine group (OR 1.55; 95% CI 1.11–2.17; p = 0.011). Consistently, the former group presented a lower mean IQ than the latter (p = 0.006). High iodine intake was associated with lower IQs even in a population classified as iodine-adequate. These results bear on child cognition and on initiatives involving iodine supplementation.Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCarvalho, Irene P.Peixoto, BrunoCaldas, José CarlosCosta, AnaSilva, SofiaMoreira, BárbaraAlmeida, AgostinhoMoreira-Rosário, AndréGuerra, AntónioDelerue-Matos, CristinaSintra, DianaPestana, DiogoPinto, EdgarMendes, Francisca CastroMartins, InêsLeite, João CostaFontoura, ManuelMaia, Maria LuzQueirós, PedroMoreira, RoxanaLeal, SandraNorberto, SóniaCosta, VeraFernandes, Virgínia CruzKeating, ElisaAzevedo, LuísCalhau, Conceição2022-11-28T22:15:41Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/145855eng1422-8599PURE: 47875716https://doi.org/10.3390/nu14214493info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:32Zoai:run.unl.pt:10362/145855Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:18.138013Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| title |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| spellingShingle |
Association between Elevated Iodine Intake and IQ among School Children in Portugal Carvalho, Irene P. cognition excessive iodine iodine-adequate population representative sample school ages Food Science Nutrition and Dietetics |
| title_short |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| title_full |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| title_fullStr |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| title_full_unstemmed |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| title_sort |
Association between Elevated Iodine Intake and IQ among School Children in Portugal |
| author |
Carvalho, Irene P. |
| author_facet |
Carvalho, Irene P. Peixoto, Bruno Caldas, José Carlos Costa, Ana Silva, Sofia Moreira, Bárbara Almeida, Agostinho Moreira-Rosário, André Guerra, António Delerue-Matos, Cristina Sintra, Diana Pestana, Diogo Pinto, Edgar Mendes, Francisca Castro Martins, Inês Leite, João Costa Fontoura, Manuel Maia, Maria Luz Queirós, Pedro Moreira, Roxana Leal, Sandra Norberto, Sónia Costa, Vera Fernandes, Virgínia Cruz Keating, Elisa Azevedo, Luís Calhau, Conceição |
| author_role |
author |
| author2 |
Peixoto, Bruno Caldas, José Carlos Costa, Ana Silva, Sofia Moreira, Bárbara Almeida, Agostinho Moreira-Rosário, André Guerra, António Delerue-Matos, Cristina Sintra, Diana Pestana, Diogo Pinto, Edgar Mendes, Francisca Castro Martins, Inês Leite, João Costa Fontoura, Manuel Maia, Maria Luz Queirós, Pedro Moreira, Roxana Leal, Sandra Norberto, Sónia Costa, Vera Fernandes, Virgínia Cruz Keating, Elisa Azevedo, Luís Calhau, Conceição |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Carvalho, Irene P. Peixoto, Bruno Caldas, José Carlos Costa, Ana Silva, Sofia Moreira, Bárbara Almeida, Agostinho Moreira-Rosário, André Guerra, António Delerue-Matos, Cristina Sintra, Diana Pestana, Diogo Pinto, Edgar Mendes, Francisca Castro Martins, Inês Leite, João Costa Fontoura, Manuel Maia, Maria Luz Queirós, Pedro Moreira, Roxana Leal, Sandra Norberto, Sónia Costa, Vera Fernandes, Virgínia Cruz Keating, Elisa Azevedo, Luís Calhau, Conceição |
| dc.subject.por.fl_str_mv |
cognition excessive iodine iodine-adequate population representative sample school ages Food Science Nutrition and Dietetics |
| topic |
cognition excessive iodine iodine-adequate population representative sample school ages Food Science Nutrition and Dietetics |
| description |
Funding Information: This project was funded through grants by the Public Health Initiatives Programme (PT06), financed by EEA Grants Financial Mechanism 2009–2014, and supported by FEDER through the operation POCI-01-0145-FEDER-007746 funded by the Programa Operacional Competitividade e Internacionalização—COMPETE2020 and by National Funds through FCT—Fundação para a Ciência e a Tecnologia, I.P., within CINTESIS, R&D Unit (reference UIDP/4255/2020) and within the scope of the project RISE, Associated Laboratory (reference LA/P/0053/2020). DP and VCF also received individual funding from Fundação para a Ciência e a Tecnologia (SFRH/BPD/109158/2015 in the first case; SFRH/BPD/109153/2015, UIDB/50006/2020, UIDP/50006/2020, and LA/P/0008/2020 in the second case). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-28T22:15:41Z 2022-11 2022-11-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/145855 |
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http://hdl.handle.net/10362/145855 |
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eng |
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eng |
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1422-8599 PURE: 47875716 https://doi.org/10.3390/nu14214493 |
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openAccess |
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