Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.9/2415 |
Resumo: | In occupational assessments where workers are exposed to metal dust, the liquid condensate of exhaled breath (EBC) may provide unique indication of pulmonary exposure. The main goal of this study was to demonstrate the quality of EBC to biological monitoring of human exposure. A pilot study was performed in a group of metal dust–exposed workers and a group of nonexposed individuals working in offices. Only metal dust–exposed workers were followed along the working week to determine the best time of collection. Metal analyses were performed with inductively coupled plasma mass spectrometry (ICP-MS). Analytical methodology was tested using an EBC sample pool for several occupationally exposed metals: potassium, chromium, manganese, copper, zinc, strontium, cadmium, antimony, and lead. Metal contents in EBC of exposed workers were higher than controls at the beginning of the shift and remained augmented throughout the working week. The results obtained support the establishment of EBC as an indicator of pulmonary exposure to metals. |
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Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimizationMetal exposureBiomonitoringICP-MSLeadTXRFIn occupational assessments where workers are exposed to metal dust, the liquid condensate of exhaled breath (EBC) may provide unique indication of pulmonary exposure. The main goal of this study was to demonstrate the quality of EBC to biological monitoring of human exposure. A pilot study was performed in a group of metal dust–exposed workers and a group of nonexposed individuals working in offices. Only metal dust–exposed workers were followed along the working week to determine the best time of collection. Metal analyses were performed with inductively coupled plasma mass spectrometry (ICP-MS). Analytical methodology was tested using an EBC sample pool for several occupationally exposed metals: potassium, chromium, manganese, copper, zinc, strontium, cadmium, antimony, and lead. Metal contents in EBC of exposed workers were higher than controls at the beginning of the shift and remained augmented throughout the working week. The results obtained support the establishment of EBC as an indicator of pulmonary exposure to metals.Taylor & FrancisRepositório do LNEGFélix, P. M.Franco, C.Barreiros, M. AlexandraBatista, B.Bernardes, S.Garcia, S. M.Almeida, A. B.Almeida, S. M.Wolterbeek, H. Th.Pinheiro, Teresa2014-04-15T16:13:50Z2013-01-01T00:00:00Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.9/2415engFélix, P.M.; Franco, C.; Barreiros, .A.; Batista, B.; Bernardes, S.; Garcia, S.M.; Almeida, A.B.; Almeida, S.M.; Wolterbeek, H. Th.; Pinheiro, T. Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization. In: Archives of Environmental & Occupational Health, 2013, Vol. 68, nº 2, p. 72-791933-8244info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T12:27:25Zoai:repositorio.lneg.pt:10400.9/2415Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:35:18.746940Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
title |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
spellingShingle |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization Félix, P. M. Metal exposure Biomonitoring ICP-MS Lead TXRF |
title_short |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
title_full |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
title_fullStr |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
title_full_unstemmed |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
title_sort |
Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization |
author |
Félix, P. M. |
author_facet |
Félix, P. M. Franco, C. Barreiros, M. Alexandra Batista, B. Bernardes, S. Garcia, S. M. Almeida, A. B. Almeida, S. M. Wolterbeek, H. Th. Pinheiro, Teresa |
author_role |
author |
author2 |
Franco, C. Barreiros, M. Alexandra Batista, B. Bernardes, S. Garcia, S. M. Almeida, A. B. Almeida, S. M. Wolterbeek, H. Th. Pinheiro, Teresa |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do LNEG |
dc.contributor.author.fl_str_mv |
Félix, P. M. Franco, C. Barreiros, M. Alexandra Batista, B. Bernardes, S. Garcia, S. M. Almeida, A. B. Almeida, S. M. Wolterbeek, H. Th. Pinheiro, Teresa |
dc.subject.por.fl_str_mv |
Metal exposure Biomonitoring ICP-MS Lead TXRF |
topic |
Metal exposure Biomonitoring ICP-MS Lead TXRF |
description |
In occupational assessments where workers are exposed to metal dust, the liquid condensate of exhaled breath (EBC) may provide unique indication of pulmonary exposure. The main goal of this study was to demonstrate the quality of EBC to biological monitoring of human exposure. A pilot study was performed in a group of metal dust–exposed workers and a group of nonexposed individuals working in offices. Only metal dust–exposed workers were followed along the working week to determine the best time of collection. Metal analyses were performed with inductively coupled plasma mass spectrometry (ICP-MS). Analytical methodology was tested using an EBC sample pool for several occupationally exposed metals: potassium, chromium, manganese, copper, zinc, strontium, cadmium, antimony, and lead. Metal contents in EBC of exposed workers were higher than controls at the beginning of the shift and remained augmented throughout the working week. The results obtained support the establishment of EBC as an indicator of pulmonary exposure to metals. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01T00:00:00Z 2013-01-01T00:00:00Z 2014-04-15T16:13:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.9/2415 |
url |
http://hdl.handle.net/10400.9/2415 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Félix, P.M.; Franco, C.; Barreiros, .A.; Batista, B.; Bernardes, S.; Garcia, S.M.; Almeida, A.B.; Almeida, S.M.; Wolterbeek, H. Th.; Pinheiro, T. Biomarkers of exposure to metal dust in exhaled breath condensate: methodology optimization. In: Archives of Environmental & Occupational Health, 2013, Vol. 68, nº 2, p. 72-79 1933-8244 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130218708860928 |