Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/7751 |
Resumo: | Exposure to pollution is a worldwide societal challenge participating in the etiology and progression of different diseases. However, the scarce information hinders our understanding of the actual level of human exposure and its specific effects. Inadequate and excessive immune responses underlie diverse chronic diseases. Yet, it is unclear which and how toxicant exposures affect the immune system functions. There is a multiplicity of immunological outcomes and biomarkers being studied in human trials related to exposure to different toxicants but still without clear evidence of their value as biomarkers of exposure or effect. The main aim of this study was to collect scientific evidence and identify relevant immunological biomarkers used at the clinical level for toxicant exposures. We used the platform clinical trials.gov as a database tool. First, we performed a search combining research items related to toxicants and immunological parameters. The resulting117 clinical trials were examined for immune-related outcomes and specific biomarkers evaluated in subjects exposed to occupational and environmental toxicants. After categorization, relevant immunological outcomes and biomarkers were identified related to systemic and airway inflammation, modulation of immune cells, allergy and autoimmunity. In general, the immune markers related to inflammation are more frequently investigated for exposure to pollutants, namely IL-6, C-reactive protein (CRP) and nitric oxide (NO). Nevertheless, the data also indicated that prospective biomarkers of effect are gaining ground and a guiding representation of the established and novel biomarkers is suggested for upcoming trials. Finally, potential protective strategies to mitigate the adverse effects of specific toxicants are underlined for future studies. |
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Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategiesToxic compoundsClinical trialsImmunological biomarkersInflammationAllergyAutoimmune diseaseExposure to pollution is a worldwide societal challenge participating in the etiology and progression of different diseases. However, the scarce information hinders our understanding of the actual level of human exposure and its specific effects. Inadequate and excessive immune responses underlie diverse chronic diseases. Yet, it is unclear which and how toxicant exposures affect the immune system functions. There is a multiplicity of immunological outcomes and biomarkers being studied in human trials related to exposure to different toxicants but still without clear evidence of their value as biomarkers of exposure or effect. The main aim of this study was to collect scientific evidence and identify relevant immunological biomarkers used at the clinical level for toxicant exposures. We used the platform clinical trials.gov as a database tool. First, we performed a search combining research items related to toxicants and immunological parameters. The resulting117 clinical trials were examined for immune-related outcomes and specific biomarkers evaluated in subjects exposed to occupational and environmental toxicants. After categorization, relevant immunological outcomes and biomarkers were identified related to systemic and airway inflammation, modulation of immune cells, allergy and autoimmunity. In general, the immune markers related to inflammation are more frequently investigated for exposure to pollutants, namely IL-6, C-reactive protein (CRP) and nitric oxide (NO). Nevertheless, the data also indicated that prospective biomarkers of effect are gaining ground and a guiding representation of the established and novel biomarkers is suggested for upcoming trials. Finally, potential protective strategies to mitigate the adverse effects of specific toxicants are underlined for future studies.ElsevierIC-OnlineMarques da Silva, DorindaVideira, Paula AlexandraLagoa, Ricardo2022-072022-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/7751engMarques-da-Silva, Dorinda, Videira, Paula Alexandra & Lagoa, Ricardo (2022). Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies. Environmental Toxicology and Pharmacology, 93, 103886. https://doi.org/10.1016/j.etap.2022.103886.1382-6689https://doi.org/10.1016/j.etap.2022.103886info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:55:51Zoai:iconline.ipleiria.pt:10400.8/7751Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:50:37.775150Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
title |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
spellingShingle |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies Marques da Silva, Dorinda Toxic compounds Clinical trials Immunological biomarkers Inflammation Allergy Autoimmune disease |
title_short |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
title_full |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
title_fullStr |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
title_full_unstemmed |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
title_sort |
Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies |
author |
Marques da Silva, Dorinda |
author_facet |
Marques da Silva, Dorinda Videira, Paula Alexandra Lagoa, Ricardo |
author_role |
author |
author2 |
Videira, Paula Alexandra Lagoa, Ricardo |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Marques da Silva, Dorinda Videira, Paula Alexandra Lagoa, Ricardo |
dc.subject.por.fl_str_mv |
Toxic compounds Clinical trials Immunological biomarkers Inflammation Allergy Autoimmune disease |
topic |
Toxic compounds Clinical trials Immunological biomarkers Inflammation Allergy Autoimmune disease |
description |
Exposure to pollution is a worldwide societal challenge participating in the etiology and progression of different diseases. However, the scarce information hinders our understanding of the actual level of human exposure and its specific effects. Inadequate and excessive immune responses underlie diverse chronic diseases. Yet, it is unclear which and how toxicant exposures affect the immune system functions. There is a multiplicity of immunological outcomes and biomarkers being studied in human trials related to exposure to different toxicants but still without clear evidence of their value as biomarkers of exposure or effect. The main aim of this study was to collect scientific evidence and identify relevant immunological biomarkers used at the clinical level for toxicant exposures. We used the platform clinical trials.gov as a database tool. First, we performed a search combining research items related to toxicants and immunological parameters. The resulting117 clinical trials were examined for immune-related outcomes and specific biomarkers evaluated in subjects exposed to occupational and environmental toxicants. After categorization, relevant immunological outcomes and biomarkers were identified related to systemic and airway inflammation, modulation of immune cells, allergy and autoimmunity. In general, the immune markers related to inflammation are more frequently investigated for exposure to pollutants, namely IL-6, C-reactive protein (CRP) and nitric oxide (NO). Nevertheless, the data also indicated that prospective biomarkers of effect are gaining ground and a guiding representation of the established and novel biomarkers is suggested for upcoming trials. Finally, potential protective strategies to mitigate the adverse effects of specific toxicants are underlined for future studies. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07 2022-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/7751 |
url |
http://hdl.handle.net/10400.8/7751 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques-da-Silva, Dorinda, Videira, Paula Alexandra & Lagoa, Ricardo (2022). Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies. Environmental Toxicology and Pharmacology, 93, 103886. https://doi.org/10.1016/j.etap.2022.103886. 1382-6689 https://doi.org/10.1016/j.etap.2022.103886 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136998831685632 |