Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital

Detalhes bibliográficos
Autor(a) principal: Hannan, MM
Data de Publicação: 2001
Outros Autores: Peres, H, Maltez, F, Hayward, AC, Machado, J, Morgado, A, Proença, R, Nelson, MR, Bico, J, Young, DB, Gazzard, BS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/1782
Resumo: An increase in the number of new cases of tuberculosis (TB) combined with poor clinical outcome was identified among HIV-infected injecting drug users attending a large HIV unit in central Lisbon. A retrospective epidemiological and laboratory study was conducted to review all newly diagnosed cases of TB from 1995 to 1996 in the HIV unit. Results showed that from 1995 to 1996, 63% (109/173) of the Mycobacterium tuberculosis isolates from HIV-infected patients were resistant to one or more anti-tuberculosis drugs; 89% (95) of these were multidrug-resistant, i.e., resistant to at least isoniazid and rifampicin. Eighty percent of the multidrug-resistant strains (MDR) available for restriction fragment length polymorphism (RFLP) DNA fingerprinting clustered into one of two large clusters. Epidemiological data support the conclusion that the transmission of MDR-TB occurred among HIV-infected injecting drug users exposed to infectious TB cases on open wards in the HIV unit. Improved infection control measures on the HIV unit and the use of empirical therapy with six drugs once patients were suspected to have TB, reduced the incidence of MDR-TB from 42% of TB cases in 1996 to 11% in 1999.
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spelling Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon HospitalHCC INFInfecções Oportunistas Relacionadas com a SIDAAnálise por ConglomeradosInfecção HospitalarDNA BacterianoSurtos de DoençasUnidades HospitalaresHospital UrbanoControlo de InfecçãoMycobacterium TuberculosisPortugalEstudos RetrospectivosAbuso de Substâncias por Via IntravenosaTuberculose Resistente a Múltiplos MedicamentosAn increase in the number of new cases of tuberculosis (TB) combined with poor clinical outcome was identified among HIV-infected injecting drug users attending a large HIV unit in central Lisbon. A retrospective epidemiological and laboratory study was conducted to review all newly diagnosed cases of TB from 1995 to 1996 in the HIV unit. Results showed that from 1995 to 1996, 63% (109/173) of the Mycobacterium tuberculosis isolates from HIV-infected patients were resistant to one or more anti-tuberculosis drugs; 89% (95) of these were multidrug-resistant, i.e., resistant to at least isoniazid and rifampicin. Eighty percent of the multidrug-resistant strains (MDR) available for restriction fragment length polymorphism (RFLP) DNA fingerprinting clustered into one of two large clusters. Epidemiological data support the conclusion that the transmission of MDR-TB occurred among HIV-infected injecting drug users exposed to infectious TB cases on open wards in the HIV unit. Improved infection control measures on the HIV unit and the use of empirical therapy with six drugs once patients were suspected to have TB, reduced the incidence of MDR-TB from 42% of TB cases in 1996 to 11% in 1999.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEHannan, MMPeres, HMaltez, FHayward, ACMachado, JMorgado, AProença, RNelson, MRBico, JYoung, DBGazzard, BS2014-04-16T11:45:44Z20012001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/1782engJ Hosp Infect. 2001 Feb;47(2):91-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:33:19Zoai:repositorio.chlc.min-saude.pt:10400.17/1782Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:12.347544Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
title Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
spellingShingle Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
Hannan, MM
HCC INF
Infecções Oportunistas Relacionadas com a SIDA
Análise por Conglomerados
Infecção Hospitalar
DNA Bacteriano
Surtos de Doenças
Unidades Hospitalares
Hospital Urbano
Controlo de Infecção
Mycobacterium Tuberculosis
Portugal
Estudos Retrospectivos
Abuso de Substâncias por Via Intravenosa
Tuberculose Resistente a Múltiplos Medicamentos
title_short Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
title_full Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
title_fullStr Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
title_full_unstemmed Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
title_sort Investigation and Control of a Large Outbreak of Multi-Drug Resistant Tuberculosis at a Central Lisbon Hospital
author Hannan, MM
author_facet Hannan, MM
Peres, H
Maltez, F
Hayward, AC
Machado, J
Morgado, A
Proença, R
Nelson, MR
Bico, J
Young, DB
Gazzard, BS
author_role author
author2 Peres, H
Maltez, F
Hayward, AC
Machado, J
Morgado, A
Proença, R
Nelson, MR
Bico, J
Young, DB
Gazzard, BS
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Hannan, MM
Peres, H
Maltez, F
Hayward, AC
Machado, J
Morgado, A
Proença, R
Nelson, MR
Bico, J
Young, DB
Gazzard, BS
dc.subject.por.fl_str_mv HCC INF
Infecções Oportunistas Relacionadas com a SIDA
Análise por Conglomerados
Infecção Hospitalar
DNA Bacteriano
Surtos de Doenças
Unidades Hospitalares
Hospital Urbano
Controlo de Infecção
Mycobacterium Tuberculosis
Portugal
Estudos Retrospectivos
Abuso de Substâncias por Via Intravenosa
Tuberculose Resistente a Múltiplos Medicamentos
topic HCC INF
Infecções Oportunistas Relacionadas com a SIDA
Análise por Conglomerados
Infecção Hospitalar
DNA Bacteriano
Surtos de Doenças
Unidades Hospitalares
Hospital Urbano
Controlo de Infecção
Mycobacterium Tuberculosis
Portugal
Estudos Retrospectivos
Abuso de Substâncias por Via Intravenosa
Tuberculose Resistente a Múltiplos Medicamentos
description An increase in the number of new cases of tuberculosis (TB) combined with poor clinical outcome was identified among HIV-infected injecting drug users attending a large HIV unit in central Lisbon. A retrospective epidemiological and laboratory study was conducted to review all newly diagnosed cases of TB from 1995 to 1996 in the HIV unit. Results showed that from 1995 to 1996, 63% (109/173) of the Mycobacterium tuberculosis isolates from HIV-infected patients were resistant to one or more anti-tuberculosis drugs; 89% (95) of these were multidrug-resistant, i.e., resistant to at least isoniazid and rifampicin. Eighty percent of the multidrug-resistant strains (MDR) available for restriction fragment length polymorphism (RFLP) DNA fingerprinting clustered into one of two large clusters. Epidemiological data support the conclusion that the transmission of MDR-TB occurred among HIV-infected injecting drug users exposed to infectious TB cases on open wards in the HIV unit. Improved infection control measures on the HIV unit and the use of empirical therapy with six drugs once patients were suspected to have TB, reduced the incidence of MDR-TB from 42% of TB cases in 1996 to 11% in 1999.
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01T00:00:00Z
2014-04-16T11:45:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/1782
url http://hdl.handle.net/10400.17/1782
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Hosp Infect. 2001 Feb;47(2):91-7
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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