Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage

Detalhes bibliográficos
Autor(a) principal: Félix, Rafael
Data de Publicação: 2020
Outros Autores: Valentão, Patrícia, Andrade, Paula B., Félix, Carina, Novais, Sara C., Lemos, Marco F.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/5088
Resumo: This study was supported by UIDB/50006/2020 with funding from FCT/MCTES through national funds, by the FCT Strategic Project UID/MAR/04292/2019 granted to MARE, and by the grants awarded to Rafael Félix (SFRH/ BD/139763/2018). The authors also wish to acknowledge the support of the European Union through EASME Blue Labs project AMALIA, Algae-to-MArket Lab IdeAs (EASME/EMFF/2016/1.2.1.4/03/SI2.750419), project VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247-FEDER-024517), the Integrated Programme of SR&TD “Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate” (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund, SAICTPAC/0019/2015—LISBOA-01-0145-FEDER-016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC), and project “Valorização dos subprodutos do processo biotecnológico de produção de esqualeno e DHA pela microalga Aurantiochytrium sp.” (AlgaValue) (ref. 17680), ANI—Agência Nacional de Inovação, S.A., FEDER—Fundo Europeu de Desenvolvimento Regional.
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spelling Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damageLipid peroxidationLPIPNatural productsBioactive compoundsIn vitroThis study was supported by UIDB/50006/2020 with funding from FCT/MCTES through national funds, by the FCT Strategic Project UID/MAR/04292/2019 granted to MARE, and by the grants awarded to Rafael Félix (SFRH/ BD/139763/2018). The authors also wish to acknowledge the support of the European Union through EASME Blue Labs project AMALIA, Algae-to-MArket Lab IdeAs (EASME/EMFF/2016/1.2.1.4/03/SI2.750419), project VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247-FEDER-024517), the Integrated Programme of SR&TD “Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate” (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund, SAICTPAC/0019/2015—LISBOA-01-0145-FEDER-016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC), and project “Valorização dos subprodutos do processo biotecnológico de produção de esqualeno e DHA pela microalga Aurantiochytrium sp.” (AlgaValue) (ref. 17680), ANI—Agência Nacional de Inovação, S.A., FEDER—Fundo Europeu de Desenvolvimento Regional.Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety. Therefore, it has been the subject of extensive scientific research concerning the possibilities to reduce it, both in vivo and in nonliving organic matrices. It can be started by a variety of oxidants, by both ROS-dependent and -independent pathways, all of them reviewed in this document. Another feature of this reaction is the capacity of lipid peroxyl radicals to react with the non-oxidized lipids, propagating the reaction even in the absence of an external trigger. Due to these specificities of lipid peroxidation, regular antioxidant strategies—although being helpful in controlling oxidative triggers—are not tailored to tackle this challenge. Thus, more suited antioxidant compounds or technologies are required and sought after by researchers, either in the fields of medicine and physiology, or in product development and biotechnology. Despite the existence of several laboratory procedures associated with the study of lipid peroxidation, a methodology to perform bioprospecting of natural products to prevent lipid peroxidation (a Lipid Peroxidation Inhibitory Potential assay, LPIP) is not yet well established. In this review, a critical look into the possibility of testing the capacity of natural products to inhibit lipid peroxidation is presented. In vitro systems used to peroxidize a lipid sample are also reviewed on the basis of lipid substrate origin, and, for each of them, procedural insights, oxidation initiation strategies, and lipid peroxidation extent monitoring are discussed.MDPIIC-OnlineFélix, RafaelValentão, PatríciaAndrade, Paula B.Félix, CarinaNovais, Sara C.Lemos, Marco F.L.2020-08-17T11:30:36Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5088engFélix, R.; Valentão, P.; Andrade, P.B.; Félix, C.; Novais, S.C.; Lemos, M.F.L. Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage. Antioxidants 2020, 9, 231.2076-392110.3390/antiox9030231info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:50:37Zoai:iconline.ipleiria.pt:10400.8/5088Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:48:46.451466Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
title Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
spellingShingle Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
Félix, Rafael
Lipid peroxidation
LPIP
Natural products
Bioactive compounds
In vitro
title_short Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
title_full Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
title_fullStr Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
title_full_unstemmed Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
title_sort Evaluating the in vitro potential of natural extracts to protect lipids from oxidative damage
author Félix, Rafael
author_facet Félix, Rafael
Valentão, Patrícia
Andrade, Paula B.
Félix, Carina
Novais, Sara C.
Lemos, Marco F.L.
author_role author
author2 Valentão, Patrícia
Andrade, Paula B.
Félix, Carina
Novais, Sara C.
Lemos, Marco F.L.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Félix, Rafael
Valentão, Patrícia
Andrade, Paula B.
Félix, Carina
Novais, Sara C.
Lemos, Marco F.L.
dc.subject.por.fl_str_mv Lipid peroxidation
LPIP
Natural products
Bioactive compounds
In vitro
topic Lipid peroxidation
LPIP
Natural products
Bioactive compounds
In vitro
description This study was supported by UIDB/50006/2020 with funding from FCT/MCTES through national funds, by the FCT Strategic Project UID/MAR/04292/2019 granted to MARE, and by the grants awarded to Rafael Félix (SFRH/ BD/139763/2018). The authors also wish to acknowledge the support of the European Union through EASME Blue Labs project AMALIA, Algae-to-MArket Lab IdeAs (EASME/EMFF/2016/1.2.1.4/03/SI2.750419), project VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247-FEDER-024517), the Integrated Programme of SR&TD “Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate” (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund, SAICTPAC/0019/2015—LISBOA-01-0145-FEDER-016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC), and project “Valorização dos subprodutos do processo biotecnológico de produção de esqualeno e DHA pela microalga Aurantiochytrium sp.” (AlgaValue) (ref. 17680), ANI—Agência Nacional de Inovação, S.A., FEDER—Fundo Europeu de Desenvolvimento Regional.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-17T11:30:36Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/5088
url http://hdl.handle.net/10400.8/5088
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Félix, R.; Valentão, P.; Andrade, P.B.; Félix, C.; Novais, S.C.; Lemos, M.F.L. Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage. Antioxidants 2020, 9, 231.
2076-3921
10.3390/antiox9030231
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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