Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies

Detalhes bibliográficos
Autor(a) principal: Coelho Henriques, C
Data de Publicação: 2012
Outros Autores: Lourenço, F, Lopéz, B, Panarra, A, Riso, N
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2983
Resumo: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder that is characterised by the presence of antiphospholipid antibodies and a common cause of vascular thromboembolic phenomena. The management of patients with APS is currently directed to antithrombotic medications. The international therapeutic guidelines recommend oral anticoagulation with warfarin indefinitely after the first thrombotic episode. However, therapeutic guidelines lack for a minority group of patients - the patients appropriately anticoagulated with recurrent thromboembolic phenomena. The authors present a clinical report that reveals the therapeutic and diagnostic complexity of this specific group of patients. Regarding recent studies, APS has been revealed as a complex syndrome with multiple pathophysiological mechanisms previously unknown. In this context, new therapeutic approaches have been defended and empirically experienced, with potentially promising results.
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spelling Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment StrategiesAntibodies, AntiphospholipidAntiphospholipid SyndromeBronchoscopyDiagnosis, DifferentialHumansMaleMiddle AgedPulmonary EmbolismRisk FactorsThrombosisTomography, X-Ray ComputedHCC MEDAntiphospholipid syndrome (APS) is a systemic autoimmune disorder that is characterised by the presence of antiphospholipid antibodies and a common cause of vascular thromboembolic phenomena. The management of patients with APS is currently directed to antithrombotic medications. The international therapeutic guidelines recommend oral anticoagulation with warfarin indefinitely after the first thrombotic episode. However, therapeutic guidelines lack for a minority group of patients - the patients appropriately anticoagulated with recurrent thromboembolic phenomena. The authors present a clinical report that reveals the therapeutic and diagnostic complexity of this specific group of patients. Regarding recent studies, APS has been revealed as a complex syndrome with multiple pathophysiological mechanisms previously unknown. In this context, new therapeutic approaches have been defended and empirically experienced, with potentially promising results.BMJ Publishing GroupRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECoelho Henriques, CLourenço, FLopéz, BPanarra, ARiso, N2018-05-23T10:26:34Z2012-03-082012-03-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2983engBMJ Case Rep. 2012 Mar 8;2012. pii: bcr112011514710.1136/bcr.11.2011.5147info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:39Zoai:repositorio.chlc.min-saude.pt:10400.17/2983Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:17.999490Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
title Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
spellingShingle Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
Coelho Henriques, C
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Bronchoscopy
Diagnosis, Differential
Humans
Male
Middle Aged
Pulmonary Embolism
Risk Factors
Thrombosis
Tomography, X-Ray Computed
HCC MED
title_short Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
title_full Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
title_fullStr Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
title_full_unstemmed Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
title_sort Antiphospholipid Syndrome and Recurrent Thrombosis--Limitations of Current Treatment Strategies
author Coelho Henriques, C
author_facet Coelho Henriques, C
Lourenço, F
Lopéz, B
Panarra, A
Riso, N
author_role author
author2 Lourenço, F
Lopéz, B
Panarra, A
Riso, N
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Coelho Henriques, C
Lourenço, F
Lopéz, B
Panarra, A
Riso, N
dc.subject.por.fl_str_mv Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Bronchoscopy
Diagnosis, Differential
Humans
Male
Middle Aged
Pulmonary Embolism
Risk Factors
Thrombosis
Tomography, X-Ray Computed
HCC MED
topic Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Bronchoscopy
Diagnosis, Differential
Humans
Male
Middle Aged
Pulmonary Embolism
Risk Factors
Thrombosis
Tomography, X-Ray Computed
HCC MED
description Antiphospholipid syndrome (APS) is a systemic autoimmune disorder that is characterised by the presence of antiphospholipid antibodies and a common cause of vascular thromboembolic phenomena. The management of patients with APS is currently directed to antithrombotic medications. The international therapeutic guidelines recommend oral anticoagulation with warfarin indefinitely after the first thrombotic episode. However, therapeutic guidelines lack for a minority group of patients - the patients appropriately anticoagulated with recurrent thromboembolic phenomena. The authors present a clinical report that reveals the therapeutic and diagnostic complexity of this specific group of patients. Regarding recent studies, APS has been revealed as a complex syndrome with multiple pathophysiological mechanisms previously unknown. In this context, new therapeutic approaches have been defended and empirically experienced, with potentially promising results.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-08
2012-03-08T00:00:00Z
2018-05-23T10:26:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2983
url http://hdl.handle.net/10400.17/2983
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMJ Case Rep. 2012 Mar 8;2012. pii: bcr1120115147
10.1136/bcr.11.2011.5147
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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