Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/92470 https://doi.org/10.1007/s00404-020-05820-y |
Resumo: | Purpose Early detection of infection is of supreme importance in obstetrics; however, during pregnancy it is not reliably predicted by standard laboratory tests. We aimed to determine if procalcitonin (PCT) is a reliable predictor of chorioamnionitis (CA) in women with premature rupture of membranes (PPROM). Methods An electronic search of Scopus, ISI, Medline, Embase, ClinicalTrials.gov and the Cochrane Library databases was performed using specifed key words. We examined all English and French reports on PCT measurement after admission for PPROM and considered: human studies published between 1990 and 2019; observational studies; and randomized controlled trials. A protocol was determined previously, registered at PROSPERO as CRD42019145464. The eligibility was independently assessed by two researchers and literature search yielded 590 studies; after revision of the titles and abstracts, 46 articles were identifed as potentially eligible; eight studies were included in the meta-analysis. Primary data synthesis was performed in Review Manager Version 5.3 and average sensitivity and specifcity was calculated using Midas, Stata. Results From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28–0.73) and a modest specifcity (0.72; 95% CI 0.51–0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53–0.84), but also better specifcity (0.75; 95% CI 0.55–0.88), compared with the other infammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis. |
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Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysisProcalcitoninaParto pré-termoPreterm premature rupture of membranesPPROMChorioamnionitisPreterm birthProcalcitoninPurpose Early detection of infection is of supreme importance in obstetrics; however, during pregnancy it is not reliably predicted by standard laboratory tests. We aimed to determine if procalcitonin (PCT) is a reliable predictor of chorioamnionitis (CA) in women with premature rupture of membranes (PPROM). Methods An electronic search of Scopus, ISI, Medline, Embase, ClinicalTrials.gov and the Cochrane Library databases was performed using specifed key words. We examined all English and French reports on PCT measurement after admission for PPROM and considered: human studies published between 1990 and 2019; observational studies; and randomized controlled trials. A protocol was determined previously, registered at PROSPERO as CRD42019145464. The eligibility was independently assessed by two researchers and literature search yielded 590 studies; after revision of the titles and abstracts, 46 articles were identifed as potentially eligible; eight studies were included in the meta-analysis. Primary data synthesis was performed in Review Manager Version 5.3 and average sensitivity and specifcity was calculated using Midas, Stata. Results From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28–0.73) and a modest specifcity (0.72; 95% CI 0.51–0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53–0.84), but also better specifcity (0.75; 95% CI 0.55–0.88), compared with the other infammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis.F31D-D663-4EF2 | Anabela Mota Pintoinfo:eu-repo/semantics/publishedVersion2020-10-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/92470http://hdl.handle.net/10316/92470https://doi.org/10.1007/s00404-020-05820-yeng0932-00671432-0711Areia, Ana LuísaAreia, MiguelMota-Pinto, Anabelainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T05:54:30Zoai:estudogeral.uc.pt:10316/92470Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:11:33.412408Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
title |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
spellingShingle |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis Areia, Ana Luísa Procalcitonina Parto pré-termo Preterm premature rupture of membranes PPROM Chorioamnionitis Preterm birth Procalcitonin |
title_short |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
title_full |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
title_fullStr |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
title_full_unstemmed |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
title_sort |
Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis |
author |
Areia, Ana Luísa |
author_facet |
Areia, Ana Luísa Areia, Miguel Mota-Pinto, Anabela |
author_role |
author |
author2 |
Areia, Miguel Mota-Pinto, Anabela |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Areia, Ana Luísa Areia, Miguel Mota-Pinto, Anabela |
dc.subject.por.fl_str_mv |
Procalcitonina Parto pré-termo Preterm premature rupture of membranes PPROM Chorioamnionitis Preterm birth Procalcitonin |
topic |
Procalcitonina Parto pré-termo Preterm premature rupture of membranes PPROM Chorioamnionitis Preterm birth Procalcitonin |
description |
Purpose Early detection of infection is of supreme importance in obstetrics; however, during pregnancy it is not reliably predicted by standard laboratory tests. We aimed to determine if procalcitonin (PCT) is a reliable predictor of chorioamnionitis (CA) in women with premature rupture of membranes (PPROM). Methods An electronic search of Scopus, ISI, Medline, Embase, ClinicalTrials.gov and the Cochrane Library databases was performed using specifed key words. We examined all English and French reports on PCT measurement after admission for PPROM and considered: human studies published between 1990 and 2019; observational studies; and randomized controlled trials. A protocol was determined previously, registered at PROSPERO as CRD42019145464. The eligibility was independently assessed by two researchers and literature search yielded 590 studies; after revision of the titles and abstracts, 46 articles were identifed as potentially eligible; eight studies were included in the meta-analysis. Primary data synthesis was performed in Review Manager Version 5.3 and average sensitivity and specifcity was calculated using Midas, Stata. Results From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28–0.73) and a modest specifcity (0.72; 95% CI 0.51–0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53–0.84), but also better specifcity (0.75; 95% CI 0.55–0.88), compared with the other infammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/92470 http://hdl.handle.net/10316/92470 https://doi.org/10.1007/s00404-020-05820-y |
url |
http://hdl.handle.net/10316/92470 https://doi.org/10.1007/s00404-020-05820-y |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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0932-0067 1432-0711 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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