Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Areia, Ana Luísa
Data de Publicação: 2020
Outros Autores: Areia, Miguel, Mota-Pinto, Anabela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/92470
https://doi.org/10.1007/s00404-020-05820-y
Resumo: Purpose Early detection of infection is of supreme importance in obstetrics; however, during pregnancy it is not reliably predicted by standard laboratory tests. We aimed to determine if procalcitonin (PCT) is a reliable predictor of chorioamnionitis (CA) in women with premature rupture of membranes (PPROM). Methods An electronic search of Scopus, ISI, Medline, Embase, ClinicalTrials.gov and the Cochrane Library databases was performed using specifed key words. We examined all English and French reports on PCT measurement after admission for PPROM and considered: human studies published between 1990 and 2019; observational studies; and randomized controlled trials. A protocol was determined previously, registered at PROSPERO as CRD42019145464. The eligibility was independently assessed by two researchers and literature search yielded 590 studies; after revision of the titles and abstracts, 46 articles were identifed as potentially eligible; eight studies were included in the meta-analysis. Primary data synthesis was performed in Review Manager Version 5.3 and average sensitivity and specifcity was calculated using Midas, Stata. Results From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28–0.73) and a modest specifcity (0.72; 95% CI 0.51–0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53–0.84), but also better specifcity (0.75; 95% CI 0.55–0.88), compared with the other infammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis.
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spelling Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysisProcalcitoninaParto pré-termoPreterm premature rupture of membranesPPROMChorioamnionitisPreterm birthProcalcitoninPurpose Early detection of infection is of supreme importance in obstetrics; however, during pregnancy it is not reliably predicted by standard laboratory tests. We aimed to determine if procalcitonin (PCT) is a reliable predictor of chorioamnionitis (CA) in women with premature rupture of membranes (PPROM). Methods An electronic search of Scopus, ISI, Medline, Embase, ClinicalTrials.gov and the Cochrane Library databases was performed using specifed key words. We examined all English and French reports on PCT measurement after admission for PPROM and considered: human studies published between 1990 and 2019; observational studies; and randomized controlled trials. A protocol was determined previously, registered at PROSPERO as CRD42019145464. The eligibility was independently assessed by two researchers and literature search yielded 590 studies; after revision of the titles and abstracts, 46 articles were identifed as potentially eligible; eight studies were included in the meta-analysis. Primary data synthesis was performed in Review Manager Version 5.3 and average sensitivity and specifcity was calculated using Midas, Stata. Results From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28–0.73) and a modest specifcity (0.72; 95% CI 0.51–0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53–0.84), but also better specifcity (0.75; 95% CI 0.55–0.88), compared with the other infammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis.F31D-D663-4EF2 | Anabela Mota Pintoinfo:eu-repo/semantics/publishedVersion2020-10-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/92470http://hdl.handle.net/10316/92470https://doi.org/10.1007/s00404-020-05820-yeng0932-00671432-0711Areia, Ana LuísaAreia, MiguelMota-Pinto, Anabelainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T05:54:30Zoai:estudogeral.uc.pt:10316/92470Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:11:33.412408Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
title Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
spellingShingle Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
Areia, Ana Luísa
Procalcitonina
Parto pré-termo
Preterm premature rupture of membranes
PPROM
Chorioamnionitis
Preterm birth
Procalcitonin
title_short Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
title_full Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
title_fullStr Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
title_full_unstemmed Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
title_sort Procalcitonin in preterm rupture of membranes: a systematic review and meta-analysis
author Areia, Ana Luísa
author_facet Areia, Ana Luísa
Areia, Miguel
Mota-Pinto, Anabela
author_role author
author2 Areia, Miguel
Mota-Pinto, Anabela
author2_role author
author
dc.contributor.author.fl_str_mv Areia, Ana Luísa
Areia, Miguel
Mota-Pinto, Anabela
dc.subject.por.fl_str_mv Procalcitonina
Parto pré-termo
Preterm premature rupture of membranes
PPROM
Chorioamnionitis
Preterm birth
Procalcitonin
topic Procalcitonina
Parto pré-termo
Preterm premature rupture of membranes
PPROM
Chorioamnionitis
Preterm birth
Procalcitonin
description Purpose Early detection of infection is of supreme importance in obstetrics; however, during pregnancy it is not reliably predicted by standard laboratory tests. We aimed to determine if procalcitonin (PCT) is a reliable predictor of chorioamnionitis (CA) in women with premature rupture of membranes (PPROM). Methods An electronic search of Scopus, ISI, Medline, Embase, ClinicalTrials.gov and the Cochrane Library databases was performed using specifed key words. We examined all English and French reports on PCT measurement after admission for PPROM and considered: human studies published between 1990 and 2019; observational studies; and randomized controlled trials. A protocol was determined previously, registered at PROSPERO as CRD42019145464. The eligibility was independently assessed by two researchers and literature search yielded 590 studies; after revision of the titles and abstracts, 46 articles were identifed as potentially eligible; eight studies were included in the meta-analysis. Primary data synthesis was performed in Review Manager Version 5.3 and average sensitivity and specifcity was calculated using Midas, Stata. Results From the eight studies included, 335 participants with PPROM were enrolled. Our meta-analysis disclosed that PCT has a poor sensitivity (0.50; 95% CI 0.28–0.73) and a modest specifcity (0.72; 95% CI 0.51–0.87) in diagnosing CA. C-reactive protein (CRP) not only has better sensitivity (0.71; 95% CI 0.53–0.84), but also better specifcity (0.75; 95% CI 0.55–0.88), compared with the other infammatory parameters analyzed. Procalcitonin does not seems to be better than CRP in preterm rupture of membranes for chorioamnionitis diagnosis.
publishDate 2020
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https://doi.org/10.1007/s00404-020-05820-y
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https://doi.org/10.1007/s00404-020-05820-y
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