The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens

Detalhes bibliográficos
Autor(a) principal: Rodriguez-Barbosa, Jose-Ignacio
Data de Publicação: 2020
Outros Autores: Schneider, Pascal, Graca, Luis, Bühler, Leo, Perez-Simon, Jose-Antonio, Del Rio, Maria-Luisa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46428
Resumo: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimensRegulatory T cellsLymphopeniaHomeostatic proliferationTransplantationTNF/TNF receptorsGraft-versus-host diseaseGraft rejection© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote peripheral Tregs expansion and sustain their survival. This property can be leveraged to enhance tolerance to allogeneic transplants by tipping the balance of Tregs over conventional T cells during the course of immune reconstitution. This is of particular interest in peri-transplant tolerance induction protocols in which T cell depletion is applied to reduce the frequency of alloreactive T cells or in conditioning regimens that allow allogeneic bone marrow transplantation. These conditioning regimens are being implemented to limit long-term side effects of continuous immunosuppression and facilitate the establishment of a state of donor-specific tolerance. Lymphopenia-induced homeostatic proliferation in response to cytoreductive conditioning is a window of opportunity to enhance preferential expansion of Tregs during homeostatic proliferation that can be potentiated by agonist stimulation of TNFR.This work has been supported by grant FIS PI13/00029 (Fondo de Investigaciones Sanitarias, Ministry of Health, Spanish Government and co-funded by European Union ERDF/ESF, “Investing in your future”), LE093U13 and Unit of Excellence Research UIC #012 (Department of Education of the Regional Government, Junta de Castilla y Leon), and Gerencia Regional de Salud (BIO/01/15) to JIRB. It was also funded by FIS PI16/00002 (Instituto de Salud Carlos III and co-funded by European Union ERDF/ESF, “Investing in your future”) and Gerencia Regional de Salud GRS963/A/2014, GRS1142/A/2015 and GRS 1505/A/2017 to M.L.R.G. This work has been supported with funding from the Spanish National Network CIBER-ONC (oncology research) CB16/12/00480 to JAPS. PS is supported by the Swiss National Science Foundation (grant 31003A-176526).MDPIRepositório da Universidade de LisboaRodriguez-Barbosa, Jose-IgnacioSchneider, PascalGraca, LuisBühler, LeoPerez-Simon, Jose-AntonioDel Rio, Maria-Luisa2021-02-18T16:37:41Z2020-05-092020-05-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46428engInt. J. Mol. Sci. 2020, 21, 33471661-659610.3390/ijms210933471422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:44Zoai:repositorio.ul.pt:10451/46428Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:36.674028Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
title The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
spellingShingle The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
Rodriguez-Barbosa, Jose-Ignacio
Regulatory T cells
Lymphopenia
Homeostatic proliferation
Transplantation
TNF/TNF receptors
Graft-versus-host disease
Graft rejection
title_short The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
title_full The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
title_fullStr The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
title_full_unstemmed The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
title_sort The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens
author Rodriguez-Barbosa, Jose-Ignacio
author_facet Rodriguez-Barbosa, Jose-Ignacio
Schneider, Pascal
Graca, Luis
Bühler, Leo
Perez-Simon, Jose-Antonio
Del Rio, Maria-Luisa
author_role author
author2 Schneider, Pascal
Graca, Luis
Bühler, Leo
Perez-Simon, Jose-Antonio
Del Rio, Maria-Luisa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodriguez-Barbosa, Jose-Ignacio
Schneider, Pascal
Graca, Luis
Bühler, Leo
Perez-Simon, Jose-Antonio
Del Rio, Maria-Luisa
dc.subject.por.fl_str_mv Regulatory T cells
Lymphopenia
Homeostatic proliferation
Transplantation
TNF/TNF receptors
Graft-versus-host disease
Graft rejection
topic Regulatory T cells
Lymphopenia
Homeostatic proliferation
Transplantation
TNF/TNF receptors
Graft-versus-host disease
Graft rejection
description © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2020
dc.date.none.fl_str_mv 2020-05-09
2020-05-09T00:00:00Z
2021-02-18T16:37:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46428
url http://hdl.handle.net/10451/46428
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int. J. Mol. Sci. 2020, 21, 3347
1661-6596
10.3390/ijms21093347
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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