Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity

Detalhes bibliográficos
Autor(a) principal: Aires, Rita
Data de Publicação: 2016
Outros Autores: Jurberg, Arnon D., Leal, Francisca, Nóvoa, Ana, Cohn, Martin J., Mallo, Moisés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/755
Resumo: The deposited article version is a post-print version (final draft post-refereeing) and included supplementary information.
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spelling Oct4 Is a Key Regulator of Vertebrate Trunk Length DiversityOct4Hox genesvertebratesgene-expressiongenomicThe deposited article version is a post-print version (final draft post-refereeing) and included supplementary information.Vertebrates exhibit a remarkably broad variation in trunk and tail lengths. However, the evolutionary and developmental origins of this diversity remain largely unknown. Posterior Hox genes were proposed to be major players in trunk length diversification in vertebrates, but functional studies have so far failed to support this view. Here we identify the pluripotency factor Oct4 as a key regulator of trunk length in vertebrate embryos. Maintaining high Oct4 levels in axial progenitors throughout development was sufficient to extend trunk length in mouse embryos. Oct4 also shifted posterior Hox gene-expression boundaries in the extended trunks, thus providing a link between activation of these genes and the transition to tail development. Furthermore, we show that the exceptionally long trunks of snakes are likely to result from heterochronic changes in Oct4 activity during body axis extension, which may have derived from differential genomic rearrangements at the Oct4 locus during vertebrate evolution.Fundação para a Ciência e a Tecnologia grants: ( PTDC/BEX-BID/0899/2014, SFRH/BD/51876/2012); Santa Casa da Misericordia de Lisboa grant: (SCML-MC-60-2014); Howard Hughes Medical; HHMI international graduate student research fellowship.ElsevierARCAAires, RitaJurberg, Arnon D.Leal, FranciscaNóvoa, AnaCohn, Martin J.Mallo, Moisés2017-07-30T00:30:08Z2016-07-212016-07-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/755engRita Aires, Arnon D. Jurberg, Francisca Leal, Ana Nóvoa, Martin J. Cohn, Moisés Mallo, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity, Developmental Cell, Volume 38, Issue 3, 8 August 2016, Pages 262-274, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2016.06.021. (http://www.sciencedirect.com/science/article/pii/S1534580716304245)10.1016/j.devcel.2016.06.021info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:09Zoai:arca.igc.gulbenkian.pt:10400.7/755Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:58.928596Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
title Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
spellingShingle Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
Aires, Rita
Oct4
Hox genes
vertebrates
gene-expression
genomic
title_short Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
title_full Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
title_fullStr Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
title_full_unstemmed Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
title_sort Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity
author Aires, Rita
author_facet Aires, Rita
Jurberg, Arnon D.
Leal, Francisca
Nóvoa, Ana
Cohn, Martin J.
Mallo, Moisés
author_role author
author2 Jurberg, Arnon D.
Leal, Francisca
Nóvoa, Ana
Cohn, Martin J.
Mallo, Moisés
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Aires, Rita
Jurberg, Arnon D.
Leal, Francisca
Nóvoa, Ana
Cohn, Martin J.
Mallo, Moisés
dc.subject.por.fl_str_mv Oct4
Hox genes
vertebrates
gene-expression
genomic
topic Oct4
Hox genes
vertebrates
gene-expression
genomic
description The deposited article version is a post-print version (final draft post-refereeing) and included supplementary information.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-21
2016-07-21T00:00:00Z
2017-07-30T00:30:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/755
url http://hdl.handle.net/10400.7/755
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rita Aires, Arnon D. Jurberg, Francisca Leal, Ana Nóvoa, Martin J. Cohn, Moisés Mallo, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity, Developmental Cell, Volume 38, Issue 3, 8 August 2016, Pages 262-274, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2016.06.021. (http://www.sciencedirect.com/science/article/pii/S1534580716304245)
10.1016/j.devcel.2016.06.021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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