Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation

Detalhes bibliográficos
Autor(a) principal: Gil, S.
Data de Publicação: 2014
Outros Autores: Leal, R.O., McGahie, D., Sepúlveda, N., Duarte, A., Niza, M.M.R.E., Tavares, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/7211
Resumo: Articles in International Journals
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spelling Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluationFeline Immunodeficiency Virus (FIV)Recombinant-Feline Interferon Omega (rFeIFN-ω)Immune-modulationOral therapyArticles in International JournalsRecombinant-Feline Interferon-Omega (rFeIFN-ω) is an immune-modulator licensed for use subcutaneously in Feline Immunodeficiency virus (FIV) therapy. Despite oral protocols have been suggested, little is known about such use in FIV-infected cats. This study aimed to evaluate the clinical improvement, laboratory findings, concurrent viral excretion and acute phase proteins (APPs) in naturally FIV-infected cats under oral rFeIFN-ω therapy (0.1 MU/cat rFeIFN-ω PO, SID, 90 days). 11 FIV-positive cats were treated with oral rFeIFN-ω (PO Group). Results were compared to previous data from 7 FIV-positive cats treated with the subcutaneous licensed protocol (SC Group). Initial clinical scores were similar in both groups. Independently of the protocol, rFeIFN-ω induced a significant clinical improvement of treated cats. Concurrent viral excretion and APP’s variation were not significant in the PO Group. Oral rFeIFN-ω can be an effective alternative therapy for FIV-infected cats, being also an option for treatment follow-up in cats submitted to the licensed protocol.Elsevier Ltd.Repositório da Universidade de LisboaGil, S.Leal, R.O.McGahie, D.Sepúlveda, N.Duarte, A.Niza, M.M.R.E.Tavares, L.2014-09-25T16:13:13Z2014-022014-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/7211engGil, S., et al. (2014). Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation. Research in Veterinary Science, 96(1), 79–85. doi: 10.1016/j.rvsc.2013.11.0070034-528810.1016/j.rvsc.2013.11.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:37:57Zoai:www.repository.utl.pt:10400.5/7211Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:54:26.128249Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
title Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
spellingShingle Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
Gil, S.
Feline Immunodeficiency Virus (FIV)
Recombinant-Feline Interferon Omega (rFeIFN-ω)
Immune-modulation
Oral therapy
title_short Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
title_full Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
title_fullStr Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
title_full_unstemmed Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
title_sort Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation
author Gil, S.
author_facet Gil, S.
Leal, R.O.
McGahie, D.
Sepúlveda, N.
Duarte, A.
Niza, M.M.R.E.
Tavares, L.
author_role author
author2 Leal, R.O.
McGahie, D.
Sepúlveda, N.
Duarte, A.
Niza, M.M.R.E.
Tavares, L.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gil, S.
Leal, R.O.
McGahie, D.
Sepúlveda, N.
Duarte, A.
Niza, M.M.R.E.
Tavares, L.
dc.subject.por.fl_str_mv Feline Immunodeficiency Virus (FIV)
Recombinant-Feline Interferon Omega (rFeIFN-ω)
Immune-modulation
Oral therapy
topic Feline Immunodeficiency Virus (FIV)
Recombinant-Feline Interferon Omega (rFeIFN-ω)
Immune-modulation
Oral therapy
description Articles in International Journals
publishDate 2014
dc.date.none.fl_str_mv 2014-09-25T16:13:13Z
2014-02
2014-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/7211
url http://hdl.handle.net/10400.5/7211
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gil, S., et al. (2014). Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats : clinical and laboratory evaluation. Research in Veterinary Science, 96(1), 79–85. doi: 10.1016/j.rvsc.2013.11.007
0034-5288
10.1016/j.rvsc.2013.11.007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd.
publisher.none.fl_str_mv Elsevier Ltd.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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