BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/835 |
Resumo: | The deposited article is a post-print version and has been submitted to peer review. |
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BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule PairAnimalsDrosophila ProteinsDrosophila melanogasterFlagellaMaleMicroscopy, Electron, TransmissionMicrotubule-Associated ProteinsMicrotubulesProtein BindingSpermatogenesisCiliaThe deposited article is a post-print version and has been submitted to peer review.The deposited article is a pre-print versionThis deposit is composed by the main article and the supplementary materials are present in the publisher's page in the following link: https://ars.els-cdn.com/content/image/1-s2.0-S1534580712002511-mmc1.pdfCilia and flagella are involved in a variety of processes and human diseases, including ciliopathies and sterility. Their motility is often controlled by a central microtubule (MT) pair localized within the ciliary MT-based skeleton, the axoneme. We characterized the formation of the motility apparatus in detail in Drosophila spermatogenesis. We show that assembly of the central MT pair starts prior to the meiotic divisions, with nucleation of a singlet MT within the basal body of a small cilium, and that the second MT of the pair only assembles much later, upon flagella formation. BLD10/CEP135, a conserved player in centriole and flagella biogenesis, can bind and stabilize MTs and is required for the early steps of central MT pair formation. This work describes a genetically tractable system to study motile cilia formation and provides an explanation for BLD10/CEP135's role in assembling highly stable MT-based structures, such as motile axonemes and centrioles.Fundação para a Ciência e Tecnologia grants: (PTDC/BIA-BCM/105602/2008); EMBO Installation Grant; Instituto Gulbenkian de Ciência; EMBO YIP Program; European Research Council grant: ([FP7/2010]/ERC Grant “261344-CentrioleStructNumber.”); Ciência 2007; EMBO, Marie Curie Actions.ElsevierARCACarvalho-Santos, ZitaMachado, PedroAlvarez-Martins, InêsGouveia, Susana M.Jana, Swadhin C.Duarte, PauloAmado, TiagoBranco, PedroFreitas, Micael C.Silva, Sara T.N.Antony, ClaudeBandeiras, Tiago M.Bettencourt-Dias, Mónica2018-02-09T11:29:35Z2012-08-142012-08-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/835engZita Carvalho-Santos, Pedro Machado, Inês Alvarez-Martins, Susana M. Gouveia, Swadhin C. Jana, Paulo Duarte, Tiago Amado, Pedro Branco, Micael C. Freitas, Sara T.N. Silva, Claude Antony, Tiago M. Bandeiras, Mónica Bettencourt-Dias, BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair, Developmental Cell, Volume 23, Issue 2, 2012, Pages 412-424, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2012.06.001. (http://www.sciencedirect.com/science/article/pii/S1534580712002511)10.1016/j.devcel.2012.06.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:14Zoai:arca.igc.gulbenkian.pt:10400.7/835Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:03.322142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| title |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| spellingShingle |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair Carvalho-Santos, Zita Animals Drosophila Proteins Drosophila melanogaster Flagella Male Microscopy, Electron, Transmission Microtubule-Associated Proteins Microtubules Protein Binding Spermatogenesis Cilia |
| title_short |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| title_full |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| title_fullStr |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| title_full_unstemmed |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| title_sort |
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair |
| author |
Carvalho-Santos, Zita |
| author_facet |
Carvalho-Santos, Zita Machado, Pedro Alvarez-Martins, Inês Gouveia, Susana M. Jana, Swadhin C. Duarte, Paulo Amado, Tiago Branco, Pedro Freitas, Micael C. Silva, Sara T.N. Antony, Claude Bandeiras, Tiago M. Bettencourt-Dias, Mónica |
| author_role |
author |
| author2 |
Machado, Pedro Alvarez-Martins, Inês Gouveia, Susana M. Jana, Swadhin C. Duarte, Paulo Amado, Tiago Branco, Pedro Freitas, Micael C. Silva, Sara T.N. Antony, Claude Bandeiras, Tiago M. Bettencourt-Dias, Mónica |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Carvalho-Santos, Zita Machado, Pedro Alvarez-Martins, Inês Gouveia, Susana M. Jana, Swadhin C. Duarte, Paulo Amado, Tiago Branco, Pedro Freitas, Micael C. Silva, Sara T.N. Antony, Claude Bandeiras, Tiago M. Bettencourt-Dias, Mónica |
| dc.subject.por.fl_str_mv |
Animals Drosophila Proteins Drosophila melanogaster Flagella Male Microscopy, Electron, Transmission Microtubule-Associated Proteins Microtubules Protein Binding Spermatogenesis Cilia |
| topic |
Animals Drosophila Proteins Drosophila melanogaster Flagella Male Microscopy, Electron, Transmission Microtubule-Associated Proteins Microtubules Protein Binding Spermatogenesis Cilia |
| description |
The deposited article is a post-print version and has been submitted to peer review. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-08-14 2012-08-14T00:00:00Z 2018-02-09T11:29:35Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/835 |
| url |
http://hdl.handle.net/10400.7/835 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Zita Carvalho-Santos, Pedro Machado, Inês Alvarez-Martins, Susana M. Gouveia, Swadhin C. Jana, Paulo Duarte, Tiago Amado, Pedro Branco, Micael C. Freitas, Sara T.N. Silva, Claude Antony, Tiago M. Bandeiras, Mónica Bettencourt-Dias, BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair, Developmental Cell, Volume 23, Issue 2, 2012, Pages 412-424, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2012.06.001. (http://www.sciencedirect.com/science/article/pii/S1534580712002511) 10.1016/j.devcel.2012.06.001 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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