Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/37276 |
Resumo: | Background: Cancer survivors are challenging patients, as they often present increased cardiovascular risk. In this background, cardio-oncology rehabilitation frameworks for specific cancer patients have been proposed. How- ever, optimal program designs, as well as their overall safety and efficacy in different subsets of patients, are not fully ascertained. Design: Single-center, pragmatic, prospective, randomized controlled trial performed in Portugal aiming to evaluate the impact of a center-based cardiac rehabilitation program, consisting of exercise training, nutritional counselling, psychosocial management and lifestyle behavior change, compared to community-based exercise training, in cancer survivors. Methods: Adult cancer survivors (N = 80) exposed to cardiotoxic cancer treatment and/or with previous car- diovascular disease will be randomized (1:1) to receive either an eight-week cardiac rehabilitation program or community-based exercise training. Primary endpoint is cardiorespiratory fitness; secondary endpoints are physical activity, psychosocial parameters, blood pressure, body composition, lipids and inflammatory param- eters. Physical function, quality of life, fatigue, health literacy, and feasibility will be assessed; a cost- effectiveness evaluation will also be performed. Between-group differences at baseline and in the change from baseline to the end of the study will be tested with unpaired t-tests or Mann-Whitney U test. Paired t-tests or Wilcoxon signed-rank test will be performed for within-group comparisons. Conclusion: This trial will address the overall impact of a contemporary cardiac rehabilitation program frame- work in cancer survivors, as compared to a community-based exercise training. |
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Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trialCancer survivorsCardiac rehabilitationCardiorespiratory fitnessCardiovascular risk factorsExercise trainingBackground: Cancer survivors are challenging patients, as they often present increased cardiovascular risk. In this background, cardio-oncology rehabilitation frameworks for specific cancer patients have been proposed. How- ever, optimal program designs, as well as their overall safety and efficacy in different subsets of patients, are not fully ascertained. Design: Single-center, pragmatic, prospective, randomized controlled trial performed in Portugal aiming to evaluate the impact of a center-based cardiac rehabilitation program, consisting of exercise training, nutritional counselling, psychosocial management and lifestyle behavior change, compared to community-based exercise training, in cancer survivors. Methods: Adult cancer survivors (N = 80) exposed to cardiotoxic cancer treatment and/or with previous car- diovascular disease will be randomized (1:1) to receive either an eight-week cardiac rehabilitation program or community-based exercise training. Primary endpoint is cardiorespiratory fitness; secondary endpoints are physical activity, psychosocial parameters, blood pressure, body composition, lipids and inflammatory param- eters. Physical function, quality of life, fatigue, health literacy, and feasibility will be assessed; a cost- effectiveness evaluation will also be performed. Between-group differences at baseline and in the change from baseline to the end of the study will be tested with unpaired t-tests or Mann-Whitney U test. Paired t-tests or Wilcoxon signed-rank test will be performed for within-group comparisons. Conclusion: This trial will address the overall impact of a contemporary cardiac rehabilitation program frame- work in cancer survivors, as compared to a community-based exercise training.Elsevier2024-01-15T00:00:00Z2023-01-15T00:00:00Z2023-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37276eng0167-527310.1016/j.ijcard.2022.09.075Viamonte, Sofia GonçalvesJoaquim, Ana VieiraAlves, AlbertoVilela, EduardoCapela, AndreiaFerreira, CristinaDuarte, BarbaraRato, Nuno DiasTavares, Aida IsabelSantos, MárioRibeiro, Fernandoinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:11:53Zoai:ria.ua.pt:10773/37276Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:53.313792Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
title |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
spellingShingle |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial Viamonte, Sofia Gonçalves Cancer survivors Cardiac rehabilitation Cardiorespiratory fitness Cardiovascular risk factors Exercise training |
title_short |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
title_full |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
title_fullStr |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
title_full_unstemmed |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
title_sort |
Impact of a COmprehensive cardiac REhabilitation framework among high cardiovascular risk cancer survivors: protocol for the CORE trial |
author |
Viamonte, Sofia Gonçalves |
author_facet |
Viamonte, Sofia Gonçalves Joaquim, Ana Vieira Alves, Alberto Vilela, Eduardo Capela, Andreia Ferreira, Cristina Duarte, Barbara Rato, Nuno Dias Tavares, Aida Isabel Santos, Mário Ribeiro, Fernando |
author_role |
author |
author2 |
Joaquim, Ana Vieira Alves, Alberto Vilela, Eduardo Capela, Andreia Ferreira, Cristina Duarte, Barbara Rato, Nuno Dias Tavares, Aida Isabel Santos, Mário Ribeiro, Fernando |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Viamonte, Sofia Gonçalves Joaquim, Ana Vieira Alves, Alberto Vilela, Eduardo Capela, Andreia Ferreira, Cristina Duarte, Barbara Rato, Nuno Dias Tavares, Aida Isabel Santos, Mário Ribeiro, Fernando |
dc.subject.por.fl_str_mv |
Cancer survivors Cardiac rehabilitation Cardiorespiratory fitness Cardiovascular risk factors Exercise training |
topic |
Cancer survivors Cardiac rehabilitation Cardiorespiratory fitness Cardiovascular risk factors Exercise training |
description |
Background: Cancer survivors are challenging patients, as they often present increased cardiovascular risk. In this background, cardio-oncology rehabilitation frameworks for specific cancer patients have been proposed. How- ever, optimal program designs, as well as their overall safety and efficacy in different subsets of patients, are not fully ascertained. Design: Single-center, pragmatic, prospective, randomized controlled trial performed in Portugal aiming to evaluate the impact of a center-based cardiac rehabilitation program, consisting of exercise training, nutritional counselling, psychosocial management and lifestyle behavior change, compared to community-based exercise training, in cancer survivors. Methods: Adult cancer survivors (N = 80) exposed to cardiotoxic cancer treatment and/or with previous car- diovascular disease will be randomized (1:1) to receive either an eight-week cardiac rehabilitation program or community-based exercise training. Primary endpoint is cardiorespiratory fitness; secondary endpoints are physical activity, psychosocial parameters, blood pressure, body composition, lipids and inflammatory param- eters. Physical function, quality of life, fatigue, health literacy, and feasibility will be assessed; a cost- effectiveness evaluation will also be performed. Between-group differences at baseline and in the change from baseline to the end of the study will be tested with unpaired t-tests or Mann-Whitney U test. Paired t-tests or Wilcoxon signed-rank test will be performed for within-group comparisons. Conclusion: This trial will address the overall impact of a contemporary cardiac rehabilitation program frame- work in cancer survivors, as compared to a community-based exercise training. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-15T00:00:00Z 2023-01-15 2024-01-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/37276 |
url |
http://hdl.handle.net/10773/37276 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0167-5273 10.1016/j.ijcard.2022.09.075 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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