Downstream processing of amorphous and co-amorphous Olanzapine powder blends

Detalhes bibliográficos
Autor(a) principal: Costa, Nuno F. da
Data de Publicação: 2022
Outros Autores: Daniels, Rolf, Fernandes, Ana I., Pinto, João F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/44176
Resumo: This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
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spelling Downstream processing of amorphous and co-amorphous Olanzapine powder blendsOlanzapine(Co-)amorphousCohesivenessCompressibilityFlowabilityTabletsThis is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the tablets obtained were measured and compared to those of tablets made with crystalline OLZ. The flowability of the amorphous and mostly of the co-amorphous OLZ powders decreased in comparison with the crystalline OLZ due to the higher cohesiveness of the former materials. The stability of the amorphous and co-amorphous OLZ prior to and after tableting was monitored by XRPD, FTIR, and NIR spectroscopies. Tablets presented long-lasting amorphous OLZ with enhanced water solubility, but the release rate of the drug decreased in comparison with tablets containing crystalline OLZ. In physical mixtures made of crystalline OLZ and SAC, an extent of amorphization of approximately 20% was accomplished through the application of compaction pressures and dwell times of 155 MPa and 5 min, respectively. The work highlighted the stability of amorphous and co-amorphous OLZ during tableting and the positive effect of compaction pressure on the formation of co-amorphous OLZ, providing an expedited amorphization technique, given that the process development-associated hurdles were overcome.MDPIRepositório ComumCosta, Nuno F. daDaniels, RolfFernandes, Ana I.Pinto, João F.2023-03-16T15:46:14Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/44176engda Costa NF, Daniels R, Fernandes AI, Pinto JF. Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends. Pharmaceutics. 2022; 14(8):1535. https://doi.org/10.3390/pharmaceutics140815351999-492310.3390/pharmaceutics14081535info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-23T02:30:25Zoai:comum.rcaap.pt:10400.26/44176Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:45:04.292023Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Downstream processing of amorphous and co-amorphous Olanzapine powder blends
title Downstream processing of amorphous and co-amorphous Olanzapine powder blends
spellingShingle Downstream processing of amorphous and co-amorphous Olanzapine powder blends
Costa, Nuno F. da
Olanzapine
(Co-)amorphous
Cohesiveness
Compressibility
Flowability
Tablets
title_short Downstream processing of amorphous and co-amorphous Olanzapine powder blends
title_full Downstream processing of amorphous and co-amorphous Olanzapine powder blends
title_fullStr Downstream processing of amorphous and co-amorphous Olanzapine powder blends
title_full_unstemmed Downstream processing of amorphous and co-amorphous Olanzapine powder blends
title_sort Downstream processing of amorphous and co-amorphous Olanzapine powder blends
author Costa, Nuno F. da
author_facet Costa, Nuno F. da
Daniels, Rolf
Fernandes, Ana I.
Pinto, João F.
author_role author
author2 Daniels, Rolf
Fernandes, Ana I.
Pinto, João F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Costa, Nuno F. da
Daniels, Rolf
Fernandes, Ana I.
Pinto, João F.
dc.subject.por.fl_str_mv Olanzapine
(Co-)amorphous
Cohesiveness
Compressibility
Flowability
Tablets
topic Olanzapine
(Co-)amorphous
Cohesiveness
Compressibility
Flowability
Tablets
description This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-03-16T15:46:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/44176
url http://hdl.handle.net/10400.26/44176
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv da Costa NF, Daniels R, Fernandes AI, Pinto JF. Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends. Pharmaceutics. 2022; 14(8):1535. https://doi.org/10.3390/pharmaceutics14081535
1999-4923
10.3390/pharmaceutics14081535
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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