Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/63826 |
Resumo: | Supplementary data to this article can be found online at https://doi.org/10.1016/j.molliq.2019.112062. |
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Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationshipsCationic surfactantSelf-assembly1,4-Diazabicyclo[2.2.2]octaneSolubilizationFurazolidoneScience & TechnologySupplementary data to this article can be found online at https://doi.org/10.1016/j.molliq.2019.112062.Self-assembly and solubilization properties of amphiphilic mono- and bisquaternized derivatives of 1,4-diazabicyclo[2.2.2]octane (mono-CS-n and di-CS-n, where CS cationic surfactant, n=12, 14, 16, 18) was investigated by nuclear magnetic resonance with magnetic field pulse gradient. The influence of Dabco-surfactant structure (head group and length of alkyl chains) on critical micelle concentration and aggregation number of micelles was studied. The CMC of mono-CS-n are lower than CMC of di-CS-n. The aggregation numbers of mono-CS-n micelles are higher than for di-CS-n micelles. The solubilization capacity of mono-CS-n is higher than di-CS-n. The solubilization capacity of mono-CS-16 is 2.5 times higher than CTAB in the case of Orange OT as a solute, and it is close to CTAB in the case of Sudan I. The solubility of a poorly water-soluble antibacterial drug furazolidone was improved by micellar solubilization based on mono- and di-Dabco-surfactants. Mono-CS-n is the best solubilizing agents toward furazolidone. The use of mixed composition mono-Dabco-16-furazolidone provides a significant increase in antimicrobial activity (2 times against bacteria and 8 times against fungi) and reduces 2 times the dose of each of the components in combination formulation and causes <2% haemolysis of human red blood cells at the active dose.The report study was funded by Russian Foundation for Basic Research according to the research project № 18-43-160015. The authors gratefully acknowledge the CSF-SAC FRC KSC RAS.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoPashirova, Tatiana N.Burilova, Evgeniya A.Lukashenko, Svetlana S.Gaysin, Nail K.Gnezdilov, Oleg I.Sapunova, Anastasia S.Fernandes, Ana R.Voloshina, Aleksandra D.Souto, Eliana B.Zhiltsova, Elena P.Zakharova, Lucia Ya.2019-12-152019-12-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63826engPashirova, Tatiana N.; Burilova, Evgeniya A.; Lukashenko, Svetlana S.; Gaysin, Nail K.; Gnezdilov, Oleg I.; Sapunova, Anastasia S.; Fernandes, Ana R.; Voloshina, Aleksandra D.; Souto, Eliana; Zhiltsova, Elena P.; Zakharova, Lucia Ya., Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships. Journal of Molecular Liquids, 296(112062), 20190167-732210.1016/j.molliq.2019.112062https://www.journals.elsevier.com/journal-of-molecular-liquidsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:35:57Zoai:repositorium.sdum.uminho.pt:1822/63826Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:31:54.664289Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| title |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| spellingShingle |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships Pashirova, Tatiana N. Cationic surfactant Self-assembly 1,4-Diazabicyclo[2.2.2]octane Solubilization Furazolidone Science & Technology |
| title_short |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| title_full |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| title_fullStr |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| title_full_unstemmed |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| title_sort |
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships |
| author |
Pashirova, Tatiana N. |
| author_facet |
Pashirova, Tatiana N. Burilova, Evgeniya A. Lukashenko, Svetlana S. Gaysin, Nail K. Gnezdilov, Oleg I. Sapunova, Anastasia S. Fernandes, Ana R. Voloshina, Aleksandra D. Souto, Eliana B. Zhiltsova, Elena P. Zakharova, Lucia Ya. |
| author_role |
author |
| author2 |
Burilova, Evgeniya A. Lukashenko, Svetlana S. Gaysin, Nail K. Gnezdilov, Oleg I. Sapunova, Anastasia S. Fernandes, Ana R. Voloshina, Aleksandra D. Souto, Eliana B. Zhiltsova, Elena P. Zakharova, Lucia Ya. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Pashirova, Tatiana N. Burilova, Evgeniya A. Lukashenko, Svetlana S. Gaysin, Nail K. Gnezdilov, Oleg I. Sapunova, Anastasia S. Fernandes, Ana R. Voloshina, Aleksandra D. Souto, Eliana B. Zhiltsova, Elena P. Zakharova, Lucia Ya. |
| dc.subject.por.fl_str_mv |
Cationic surfactant Self-assembly 1,4-Diazabicyclo[2.2.2]octane Solubilization Furazolidone Science & Technology |
| topic |
Cationic surfactant Self-assembly 1,4-Diazabicyclo[2.2.2]octane Solubilization Furazolidone Science & Technology |
| description |
Supplementary data to this article can be found online at https://doi.org/10.1016/j.molliq.2019.112062. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-12-15 2019-12-15T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1822/63826 |
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http://hdl.handle.net/1822/63826 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Pashirova, Tatiana N.; Burilova, Evgeniya A.; Lukashenko, Svetlana S.; Gaysin, Nail K.; Gnezdilov, Oleg I.; Sapunova, Anastasia S.; Fernandes, Ana R.; Voloshina, Aleksandra D.; Souto, Eliana; Zhiltsova, Elena P.; Zakharova, Lucia Ya., Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships. Journal of Molecular Liquids, 296(112062), 2019 0167-7322 10.1016/j.molliq.2019.112062 https://www.journals.elsevier.com/journal-of-molecular-liquids |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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