Influenza B-Associated Atypical Hemolytic Uremic Syndrome

Detalhes bibliográficos
Autor(a) principal: Mano,Lia
Data de Publicação: 2022
Outros Autores: Francisco,Telma, Gaspar,Joana, Pereira,Gabriela, Santos,Raquel, Abranches,Margarida
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692022000200080
Resumo: ABSTRACT Hemolytic uremic syndrome (HUS) triggered by influenza virus (iHUS) is rare. Influenza A infections have been described to trigger atypical HUS (aHUS) in individuals with an underlying genetic complement dysregulation. To date there are only few reports of Influenza B as a trigger of aHUS, all identified cases associated with mutations in the MCP or C3 gene, occasionally combined with other mutations. aHUS patients should be screened for all known disease-associated genes and screening should not be stopped after finding a mutation, to identify other genetic susceptibility factors influencing gene phenotype, particularly in patients with MCP or CFI mutations. Complement blockade using a monoclonal anti-C5 antibody, eculizumab, has greatly improved the outcome in recent years for certain groups of HUS. The decision on whether to treat or not with eculizumab should be made based on clinical and laboratorial evolution as well as molecular studies results. Influenza A and B are preventable through vaccination and strategies should be addressed for patients with complemente gene mutations identified.
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spelling Influenza B-Associated Atypical Hemolytic Uremic SyndromeAtypical Hemolytic Uremic Syndrome/geneticsAtypical Hemolytic Uremic Syndrome/drug therapyAtypical Hemolytic Uremic Syndrome/immunologyEculizumabInfluenza VaccinesInfluenza B virus/geneticsVaccinationABSTRACT Hemolytic uremic syndrome (HUS) triggered by influenza virus (iHUS) is rare. Influenza A infections have been described to trigger atypical HUS (aHUS) in individuals with an underlying genetic complement dysregulation. To date there are only few reports of Influenza B as a trigger of aHUS, all identified cases associated with mutations in the MCP or C3 gene, occasionally combined with other mutations. aHUS patients should be screened for all known disease-associated genes and screening should not be stopped after finding a mutation, to identify other genetic susceptibility factors influencing gene phenotype, particularly in patients with MCP or CFI mutations. Complement blockade using a monoclonal anti-C5 antibody, eculizumab, has greatly improved the outcome in recent years for certain groups of HUS. The decision on whether to treat or not with eculizumab should be made based on clinical and laboratorial evolution as well as molecular studies results. Influenza A and B are preventable through vaccination and strategies should be addressed for patients with complemente gene mutations identified.Sociedade Portuguesa de Nefrologia2022-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692022000200080Portuguese Journal of Nephrology & Hypertension v.36 n.2 2022reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692022000200080Mano,LiaFrancisco,TelmaGaspar,JoanaPereira,GabrielaSantos,RaquelAbranches,Margaridainfo:eu-repo/semantics/openAccess2024-02-06T17:05:13Zoai:scielo:S0872-01692022000200080Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:07.649436Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influenza B-Associated Atypical Hemolytic Uremic Syndrome
title Influenza B-Associated Atypical Hemolytic Uremic Syndrome
spellingShingle Influenza B-Associated Atypical Hemolytic Uremic Syndrome
Mano,Lia
Atypical Hemolytic Uremic Syndrome/genetics
Atypical Hemolytic Uremic Syndrome/drug therapy
Atypical Hemolytic Uremic Syndrome/immunology
Eculizumab
Influenza Vaccines
Influenza B virus/genetics
Vaccination
title_short Influenza B-Associated Atypical Hemolytic Uremic Syndrome
title_full Influenza B-Associated Atypical Hemolytic Uremic Syndrome
title_fullStr Influenza B-Associated Atypical Hemolytic Uremic Syndrome
title_full_unstemmed Influenza B-Associated Atypical Hemolytic Uremic Syndrome
title_sort Influenza B-Associated Atypical Hemolytic Uremic Syndrome
author Mano,Lia
author_facet Mano,Lia
Francisco,Telma
Gaspar,Joana
Pereira,Gabriela
Santos,Raquel
Abranches,Margarida
author_role author
author2 Francisco,Telma
Gaspar,Joana
Pereira,Gabriela
Santos,Raquel
Abranches,Margarida
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mano,Lia
Francisco,Telma
Gaspar,Joana
Pereira,Gabriela
Santos,Raquel
Abranches,Margarida
dc.subject.por.fl_str_mv Atypical Hemolytic Uremic Syndrome/genetics
Atypical Hemolytic Uremic Syndrome/drug therapy
Atypical Hemolytic Uremic Syndrome/immunology
Eculizumab
Influenza Vaccines
Influenza B virus/genetics
Vaccination
topic Atypical Hemolytic Uremic Syndrome/genetics
Atypical Hemolytic Uremic Syndrome/drug therapy
Atypical Hemolytic Uremic Syndrome/immunology
Eculizumab
Influenza Vaccines
Influenza B virus/genetics
Vaccination
description ABSTRACT Hemolytic uremic syndrome (HUS) triggered by influenza virus (iHUS) is rare. Influenza A infections have been described to trigger atypical HUS (aHUS) in individuals with an underlying genetic complement dysregulation. To date there are only few reports of Influenza B as a trigger of aHUS, all identified cases associated with mutations in the MCP or C3 gene, occasionally combined with other mutations. aHUS patients should be screened for all known disease-associated genes and screening should not be stopped after finding a mutation, to identify other genetic susceptibility factors influencing gene phenotype, particularly in patients with MCP or CFI mutations. Complement blockade using a monoclonal anti-C5 antibody, eculizumab, has greatly improved the outcome in recent years for certain groups of HUS. The decision on whether to treat or not with eculizumab should be made based on clinical and laboratorial evolution as well as molecular studies results. Influenza A and B are preventable through vaccination and strategies should be addressed for patients with complemente gene mutations identified.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692022000200080
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dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.36 n.2 2022
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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