Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.13/3846 |
Resumo: | Background Diabetes has been defi ned on the basis of diff erent biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the eff ect of diff erent diagnostic defi nitions on both the population prevalence of diabetes and the classifi cation of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in diff erent regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defi ning diabetes. Diabetes was defi ned using HbA1c (HbA1c ≥6·5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT defi nitions (FPG ≥7·0 mmol/L or 2hOGTT ≥11·1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using diff erent defi nitions graphically and by regression analyses. We calculated sensitivity and specifi city of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specifi city in each survey, and then pooled results using a random-eff ects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG-or-2hOGTT was correlated with prevalence based on FPG alone (r=0·98), but was higher by 2–6 percentage points at diff erent prevalence levels. Prevalence based on HbA1c was lower than prevalence based on FPG in 42·8% of age–sex–survey groups and higher in another 41·6%; in the other 15·6%, the two defi nitions provided similar prevalence estimates. The variation across studies in the relation between glucose-based and HbA1c-based prevalences was partly related to participants’ age, followed by natural logarithm of per person gross domestic product, the year of survey, mean BMI, and whether the survey population was national, subnational, or from specifi c communities. Diabetes defi ned as HbA1c 6·5% or more had a pooled sensitivity of 52·8% (95% CI 51·3–54·3%) and a pooled specifi city of 99·74% (99·71–99·78%) compared with FPG 7·0 mmol/L or more for diagnosing previously undiagnosed participants; sensitivity compared with diabetes defi ned based on FPG or-2hOGTT was 30·5% (28·7–32·3%). None of the preselected study-level characteristics explained the heterogeneity in the sensitivity of HbA1c versus FPG. Interpretation Diff erent biomarkers and defi nitions for diabetes can provide diff erent estimates of population prevalence of diabetes, and diff erentially identify people without previous diagnosis as having diabetes. Using an HbA1c-based defi nition alone in health surveys will not identify a substantial proportion of previously undiagnosed people who would be considered as having diabetes using a glucose-based test. |
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Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participantsDiabetesEffects of diabetesDiabetes prevalenceDiabetes diagnosisGlobal surveillance of diabetes.Faculdade de Ciências SociaisBackground Diabetes has been defi ned on the basis of diff erent biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the eff ect of diff erent diagnostic defi nitions on both the population prevalence of diabetes and the classifi cation of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in diff erent regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defi ning diabetes. Diabetes was defi ned using HbA1c (HbA1c ≥6·5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT defi nitions (FPG ≥7·0 mmol/L or 2hOGTT ≥11·1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using diff erent defi nitions graphically and by regression analyses. We calculated sensitivity and specifi city of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specifi city in each survey, and then pooled results using a random-eff ects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG-or-2hOGTT was correlated with prevalence based on FPG alone (r=0·98), but was higher by 2–6 percentage points at diff erent prevalence levels. Prevalence based on HbA1c was lower than prevalence based on FPG in 42·8% of age–sex–survey groups and higher in another 41·6%; in the other 15·6%, the two defi nitions provided similar prevalence estimates. The variation across studies in the relation between glucose-based and HbA1c-based prevalences was partly related to participants’ age, followed by natural logarithm of per person gross domestic product, the year of survey, mean BMI, and whether the survey population was national, subnational, or from specifi c communities. Diabetes defi ned as HbA1c 6·5% or more had a pooled sensitivity of 52·8% (95% CI 51·3–54·3%) and a pooled specifi city of 99·74% (99·71–99·78%) compared with FPG 7·0 mmol/L or more for diagnosing previously undiagnosed participants; sensitivity compared with diabetes defi ned based on FPG or-2hOGTT was 30·5% (28·7–32·3%). None of the preselected study-level characteristics explained the heterogeneity in the sensitivity of HbA1c versus FPG. Interpretation Diff erent biomarkers and defi nitions for diabetes can provide diff erent estimates of population prevalence of diabetes, and diff erentially identify people without previous diagnosis as having diabetes. Using an HbA1c-based defi nition alone in health surveys will not identify a substantial proportion of previously undiagnosed people who would be considered as having diabetes using a glucose-based test.ElsevierDigitUMaDanaei, GFahimi, SLu, YZhou, BHajifathalian, KDi Cesare, MLo, WCReis-Santos, BCowan, MJShaw, JEBentham, JJonas, JBJoshi, PKafatos, AKalter-Leibovici, OKasaeian, AKatz, JKaur, PKavousi, MKelishadi, RAli, MKDhana, KKengne, APKersting, MKhader, YSKhang, YHKiechl, SKim, JKiyohara, YKolsteren, PKorrovits, PKoskinen, SDi Castelnuovo, AFEzzati, MKratzer, WKromhout, DKula, KKurjata, PKyobutungi, CLachat, CLaid, YLam, THLanska, VDjalalinia, SLappas, GAbdeen, ZALaxmaiah, ALeclercq, CLee, JLee, JLehtimäki, TLekhraj, RLeón-Muñoz, LMLi, YDoua, KLim, WYLima-Costa, MFKadir, KALin, HHLin, XLissner, LLorbeer, RLozano, JELundqvist, ALytsy, PDrygas, WMa, GMachado-Coelho, GLMachi, SAbu-Rmeileh, MMaggi, SMagliano, DMakdisse, MMallikharjuna v, KManios, YManzato, EDu, YMargozzini, PMarques-Vidal, PMartorell, RMasoodi, SRAcosta-Cazares, BMatsha, TEMbanya, JCMcFarlane, SRMcGarvey, STMcLachlan, SEgbagbe, EEMcNulty, BAMediene-Benchekor, SMeirhaeghe, AMenezes, AMMerat, SAekplakorn, WMeshram, IIMi, JMiquel, JFMiranda, JJEggertsen, RMohamed, MKMohammad, KMohan, VMohd Yusoff, MFMøller, NCMolnar, DAguilar-Salinas, CAMondo, CKMoreno, LAMorgan, KEl Ati, JMoschonis, GMossakowska, MMostafa, AMota, JMuiesan, MLMüller-Nurasyid, MMursu, JAhmadvand, ANagel, GNámešná, JElosua, RNang, EENangia, VBNavarrete-Muñoz, EMNdiaye, NCNervi, FNguyen, NDNieto-Martínez, REAlvarado, LAl Nsour, MNing, GLin, JKNinomiya, TNoale, MNoto, DOchoa-Avilés, MOh, KOnat, AOsmond, COtero, JAPalmieri, LAlkerwi, AErasmus, RTPanda-Jonas, SPanza, FParsaeian, MPeixoto, SVPereira, ACPeters, APeykari, NPilav, APitakaka, FPiwonska, AErem, CAmouyel, PPiwonski, JPlans-Rubió, PPorta, MPortegies, MLPoustchi, HPradeepa, RPrice, JFPunab, MQasrawi, RFErgor, GQorbani, MAndersen, L. B.Raitakari, ORamachandra Rao, SRamachandran, ARamos, RRampal, SRathmann, WRedon, JReganit, PFEriksen, LRigo, FRobinson, SMAnderssen, S. A.Robitaille, CRodríguez, LARodríguez-Artalejo, Fdel Cristo Rodriguez-Perez, MRojas-Martinez, RRomaguera, DRosengren, AEscobedo-de la Peña, JRubinstein, AOrnelas, RuiRuiz-Betancourt, BSAndrade, DSRutkowski, MSabanayagam, CSachdev, HSSaidi, OSakarya, SSalanave, BFall, CHSalonen, JTSalvetti, MSánchez-Abanto, JSantos, RNAnjana, RMSantos, RSardinha, LBScazufca, MSchargrodsky, HScheidt-Nave, CFarzadfar, FShaw, JEShibuya, KShin, YShiri, RSiantar, RAounallah-Skhiri, HSibai, AMSimon, MSimons, JSimons, LAFelix-Redondo, FJSjostrom, MSlowikowska-Hilczer, JSlusarczyk, PSmeeth, LSnijder, MBSolfrizzi, VAris, TSonestedt, ESoumare, AStaessen, JAFerguson, TSSteene-Johannessen, JStehle, PStein, ADStessman, JStöckl, DStokwiszewski, JStrufaldi, MWArlappa, NSun, CASundström, JFernández-Bergés, DSuriyawongpaisal, PSy, RGTai, ESTarawneh, MTarqui-Mamani, CBThijs, LTolstrup, JSTopbas, MArveiler, DTorrent, MBixby, HTraissac, PTrinh, OTTulloch-Reid, MKTuomainen, TPTurley, MLTzourio, CUeda, PUkoli, FMUlmer, HAssah, FKFerrari, MValdivia, Gvan Valkengoed, IGVanderschueren, DVanuzzo, DVega, TVelasquez-Melendez, GVeronesi, GVerschuren, MVioque, JVirtanen, JFerreccio, CAvdicová, MVisvikis-Siest, SViswanathan, BVollenweider, PVoutilainen, SWade, ANWagner, AWalton, JMohamud, WNWang, MDFinn, JDWang, YXBalakrishna, NWannamethee, SGWeerasekera, DWhincup, PHWidhalm, KWiecek, AWilks, RJWilleit, JWojtyniak, BFöger, BWong, TYWoo, JBandosz, PWoodward, MWu, AGWu, FCWu, SLXu, HYang, XYe, XFoo, LHYoshihara, AYounger-Coleman, NOZambon, SBarbagallo, CMZargar, AHZdrojewski, TZhao, WZheng, YBarceló, ABatieha, AMFouad, HMBaur, LABen Romdhane, HBernabe-Ortiz, ABhargava, SKBi, YBjerregaard, PBjörkelund, CBlake, MBlokstra, ABo, SFrancis, DKBoehm, BOBoissonnet, CPBovet, PBrajkovich, IBreckenkamp, JBrewster, LMBrian, GRBruno, GBugge, ACabrera de León, AFranco Mdo, CCan, GCândido, APCapuano, VCarvalho, M. J.Casanueva, FFCaserta, CACastetbon, KChamukuttan, SChaturvedi, NChen, CJFrontera, GChen, FChen, SCheng, CYChetrit, AChiou, STCho, YChudek, JCifkova, RClaessens, FConcin, HFurusawa, TCooper, CCooper, RCostanzo, SCottel, DCowell, CCrujeiras, ABD'Arrigo, GDallongeville, JDankner, RDauchet, LMagliano, Dde Gaetano, GDe Henauw, SDeepa, MDehghan, AGaciong, ZGalbarczyk, AGarnett, SPGaspoz, JMGasull, MGates, LGeleijnse, JMGhasemain, AGiampaoli, SGianfagna, FBovet, PGiovannelli, JGonzalez Gross, MGonzález Rivas, JPGorbea, MBGottrand, FGrant, JFGrodzicki, TGrøntved, AGruden, GGu, DMiranda, JJGuan, OPGuerrero, RGuessous, IGuimaraes, ALGutierrez, LHardy, RHari Kumar, RHeidemann, CHihtaniemi, ITHo, SYKhang, YHHo, SCHofman, AHorimoto, ARHormiga, CMHorta, BLHouti, LHussieni, ASHuybrechts, IHwalla, NIacoviello, LStevens, GAIannone, AGIbrahim, MMIkeda, NIkram, MAIrazola, VEIslam, MIwasaki, MJacobs, JMJafar, TJasienska, GRiley, LMJiang, CQ2021-11-23T15:34:12Z2015-01-01T00:00:00Z2015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/3846engDanaei, G., Fahimi, S., Lu, Y., Zhou, B., Hajifathalian, K., Di Cesare, M., ... & Guan, O. P. (2015). Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants. The Lancet Diabetes & Endocrinology, 3(8), 624-637. https://doi.org/10.1016/S2213-8587(15)00129-110.1016/S2213-8587(15)00129-1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-25T03:30:19Zoai:digituma.uma.pt:10400.13/3846Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:07:24.959690Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
title |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
spellingShingle |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants Danaei, G Diabetes Effects of diabetes Diabetes prevalence Diabetes diagnosis Global surveillance of diabetes . Faculdade de Ciências Sociais |
title_short |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
title_full |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
title_fullStr |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
title_full_unstemmed |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
title_sort |
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants |
author |
Danaei, G |
author_facet |
Danaei, G Fahimi, S Lu, Y Zhou, B Hajifathalian, K Di Cesare, M Lo, WC Reis-Santos, B Cowan, MJ Shaw, JE Bentham, J Jonas, JB Joshi, P Kafatos, A Kalter-Leibovici, O Kasaeian, A Katz, J Kaur, P Kavousi, M Kelishadi, R Ali, MK Dhana, K Kengne, AP Kersting, M Khader, YS Khang, YH Kiechl, S Kim, J Kiyohara, Y Kolsteren, P Korrovits, P Koskinen, S Di Castelnuovo, AF Ezzati, M Kratzer, W Kromhout, D Kula, K Kurjata, P Kyobutungi, C Lachat, C Laid, Y Lam, TH Lanska, V Djalalinia, S Lappas, G Abdeen, ZA Laxmaiah, A Leclercq, C Lee, J Lehtimäki, T Lekhraj, R León-Muñoz, LM Li, Y Doua, K Lim, WY Lima-Costa, MF Kadir, KA Lin, HH Lin, X Lissner, L Lorbeer, R Lozano, JE Lundqvist, A Lytsy, P Drygas, W Ma, G Machado-Coelho, GL Machi, S Abu-Rmeileh, M Maggi, S Magliano, D Makdisse, M Mallikharjuna v, K Manios, Y Manzato, E Du, Y Margozzini, P Marques-Vidal, P Martorell, R Masoodi, SR Acosta-Cazares, B Matsha, TE Mbanya, JC McFarlane, SR McGarvey, ST McLachlan, S Egbagbe, EE McNulty, BA Mediene-Benchekor, S Meirhaeghe, A Menezes, AM Merat, S Aekplakorn, W Meshram, II Mi, J Miquel, JF Miranda, JJ Eggertsen, R Mohamed, MK Mohammad, K Mohan, V Mohd Yusoff, MF Møller, NC Molnar, D Aguilar-Salinas, CA Mondo, CK Moreno, LA Morgan, K El Ati, J Moschonis, G Mossakowska, M Mostafa, A Mota, J Muiesan, ML Müller-Nurasyid, M Mursu, J Ahmadvand, A Nagel, G Námešná, J Elosua, R Nang, EE Nangia, VB Navarrete-Muñoz, EM Ndiaye, NC Nervi, F Nguyen, ND Nieto-Martínez, RE Alvarado, L Al Nsour, M Ning, G Lin, JK Ninomiya, T Noale, M Noto, D Ochoa-Avilés, M Oh, K Onat, A Osmond, C Otero, JA Palmieri, L Alkerwi, A Erasmus, RT Panda-Jonas, S Panza, F Parsaeian, M Peixoto, SV Pereira, AC Peters, A Peykari, N Pilav, A Pitakaka, F Piwonska, A Erem, C Amouyel, P Piwonski, J Plans-Rubió, P Porta, M Portegies, ML Poustchi, H Pradeepa, R Price, JF Punab, M Qasrawi, RF Ergor, G Qorbani, M Andersen, L. B. Raitakari, O Ramachandra Rao, S Ramachandran, A Ramos, R Rampal, S Rathmann, W Redon, J Reganit, PF Eriksen, L Rigo, F Robinson, SM Anderssen, S. A. Robitaille, C Rodríguez, LA Rodríguez-Artalejo, F del Cristo Rodriguez-Perez, M Rojas-Martinez, R Romaguera, D Rosengren, A Escobedo-de la Peña, J Rubinstein, A Ornelas, Rui Ruiz-Betancourt, BS Andrade, DS Rutkowski, M Sabanayagam, C Sachdev, HS Saidi, O Sakarya, S Salanave, B Fall, CH Salonen, JT Salvetti, M Sánchez-Abanto, J Santos, RN Anjana, RM Santos, R Sardinha, LB Scazufca, M Schargrodsky, H Scheidt-Nave, C Farzadfar, F Shibuya, K Shin, Y Shiri, R Siantar, R Aounallah-Skhiri, H Sibai, AM Simon, M Simons, J Simons, LA Felix-Redondo, FJ Sjostrom, M Slowikowska-Hilczer, J Slusarczyk, P Smeeth, L Snijder, MB Solfrizzi, V Aris, T Sonestedt, E Soumare, A Staessen, JA Ferguson, TS Steene-Johannessen, J Stehle, P Stein, AD Stessman, J Stöckl, D Stokwiszewski, J Strufaldi, MW Arlappa, N Sun, CA Sundström, J Fernández-Bergés, D Suriyawongpaisal, P Sy, RG Tai, ES Tarawneh, M Tarqui-Mamani, CB Thijs, L Tolstrup, JS Topbas, M Arveiler, D Torrent, M Bixby, H Traissac, P Trinh, OT Tulloch-Reid, MK Tuomainen, TP Turley, ML Tzourio, C Ueda, P Ukoli, FM Ulmer, H Assah, FK Ferrari, M Valdivia, G van Valkengoed, IG Vanderschueren, D Vanuzzo, D Vega, T Velasquez-Melendez, G Veronesi, G Verschuren, M Vioque, J Virtanen, J Ferreccio, C Avdicová, M Visvikis-Siest, S Viswanathan, B Vollenweider, P Voutilainen, S Wade, AN Wagner, A Walton, J Mohamud, WN Wang, MD Finn, JD Wang, YX Balakrishna, N Wannamethee, SG Weerasekera, D Whincup, PH Widhalm, K Wiecek, A Wilks, RJ Willeit, J Wojtyniak, B Föger, B Wong, TY Woo, J Bandosz, P Woodward, M Wu, AG Wu, FC Wu, SL Xu, H Yang, X Ye, X Foo, LH Yoshihara, A Younger-Coleman, NO Zambon, S Barbagallo, CM Zargar, AH Zdrojewski, T Zhao, W Zheng, Y Barceló, A Batieha, AM Fouad, HM Baur, LA Ben Romdhane, H Bernabe-Ortiz, A Bhargava, SK Bi, Y Bjerregaard, P Björkelund, C Blake, M Blokstra, A Bo, S Francis, DK Boehm, BO Boissonnet, CP Bovet, P Brajkovich, I Breckenkamp, J Brewster, LM Brian, GR Bruno, G Bugge, A Cabrera de León, A Franco Mdo, C Can, G Cândido, AP Capuano, V Carvalho, M. J. Casanueva, FF Caserta, CA Castetbon, K Chamukuttan, S Chaturvedi, N Chen, CJ Frontera, G Chen, F Chen, S Cheng, CY Chetrit, A Chiou, ST Cho, Y Chudek, J Cifkova, R Claessens, F Concin, H Furusawa, T Cooper, C Cooper, R Costanzo, S Cottel, D Cowell, C Crujeiras, AB D'Arrigo, G Dallongeville, J Dankner, R Dauchet, L de Gaetano, G De Henauw, S Deepa, M Dehghan, A Gaciong, Z Galbarczyk, A Garnett, SP Gaspoz, JM Gasull, M Gates, L Geleijnse, JM Ghasemain, A Giampaoli, S Gianfagna, F Giovannelli, J Gonzalez Gross, M González Rivas, JP Gorbea, MB Gottrand, F Grant, JF Grodzicki, T Grøntved, A Gruden, G Gu, D Guan, OP Guerrero, R Guessous, I Guimaraes, AL Gutierrez, L Hardy, R Hari Kumar, R Heidemann, C Hihtaniemi, IT Ho, SY Ho, SC Hofman, A Horimoto, AR Hormiga, CM Horta, BL Houti, L Hussieni, AS Huybrechts, I Hwalla, N Iacoviello, L Stevens, GA Iannone, AG Ibrahim, MM Ikeda, N Ikram, MA Irazola, VE Islam, M Iwasaki, M Jacobs, JM Jafar, T Jasienska, G Riley, LM Jiang, CQ |
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author |
author2 |
Fahimi, S Lu, Y Zhou, B Hajifathalian, K Di Cesare, M Lo, WC Reis-Santos, B Cowan, MJ Shaw, JE Bentham, J Jonas, JB Joshi, P Kafatos, A Kalter-Leibovici, O Kasaeian, A Katz, J Kaur, P Kavousi, M Kelishadi, R Ali, MK Dhana, K Kengne, AP Kersting, M Khader, YS Khang, YH Kiechl, S Kim, J Kiyohara, Y Kolsteren, P Korrovits, P Koskinen, S Di Castelnuovo, AF Ezzati, M Kratzer, W Kromhout, D Kula, K Kurjata, P Kyobutungi, C Lachat, C Laid, Y Lam, TH Lanska, V Djalalinia, S Lappas, G Abdeen, ZA Laxmaiah, A Leclercq, C Lee, J Lehtimäki, T Lekhraj, R León-Muñoz, LM Li, Y Doua, K Lim, WY Lima-Costa, MF Kadir, KA Lin, HH Lin, X Lissner, L Lorbeer, R Lozano, JE Lundqvist, A Lytsy, P Drygas, W Ma, G Machado-Coelho, GL Machi, S Abu-Rmeileh, M Maggi, S Magliano, D Makdisse, M Mallikharjuna v, K Manios, Y Manzato, E Du, Y Margozzini, P Marques-Vidal, P Martorell, R Masoodi, SR Acosta-Cazares, B Matsha, TE Mbanya, JC McFarlane, SR McGarvey, ST McLachlan, S Egbagbe, EE McNulty, BA Mediene-Benchekor, S Meirhaeghe, A Menezes, AM Merat, S Aekplakorn, W Meshram, II Mi, J Miquel, JF Miranda, JJ Eggertsen, R Mohamed, MK Mohammad, K Mohan, V Mohd Yusoff, MF Møller, NC Molnar, D Aguilar-Salinas, CA Mondo, CK Moreno, LA Morgan, K El Ati, J Moschonis, G Mossakowska, M Mostafa, A Mota, J Muiesan, ML Müller-Nurasyid, M Mursu, J Ahmadvand, A Nagel, G Námešná, J Elosua, R Nang, EE Nangia, VB Navarrete-Muñoz, EM Ndiaye, NC Nervi, F Nguyen, ND Nieto-Martínez, RE Alvarado, L Al Nsour, M Ning, G Lin, JK Ninomiya, T Noale, M Noto, D Ochoa-Avilés, M Oh, K Onat, A Osmond, C Otero, JA Palmieri, L Alkerwi, A Erasmus, RT Panda-Jonas, S Panza, F Parsaeian, M Peixoto, SV Pereira, AC Peters, A Peykari, N Pilav, A Pitakaka, F Piwonska, A Erem, C Amouyel, P Piwonski, J Plans-Rubió, P Porta, M Portegies, ML Poustchi, H Pradeepa, R Price, JF Punab, M Qasrawi, RF Ergor, G Qorbani, M Andersen, L. B. Raitakari, O Ramachandra Rao, S Ramachandran, A Ramos, R Rampal, S Rathmann, W Redon, J Reganit, PF Eriksen, L Rigo, F Robinson, SM Anderssen, S. A. Robitaille, C Rodríguez, LA Rodríguez-Artalejo, F del Cristo Rodriguez-Perez, M Rojas-Martinez, R Romaguera, D Rosengren, A Escobedo-de la Peña, J Rubinstein, A Ornelas, Rui Ruiz-Betancourt, BS Andrade, DS Rutkowski, M Sabanayagam, C Sachdev, HS Saidi, O Sakarya, S Salanave, B Fall, CH Salonen, JT Salvetti, M Sánchez-Abanto, J Santos, RN Anjana, RM Santos, R Sardinha, LB Scazufca, M Schargrodsky, H Scheidt-Nave, C Farzadfar, F Shibuya, K Shin, Y Shiri, R Siantar, R Aounallah-Skhiri, H Sibai, AM Simon, M Simons, J Simons, LA Felix-Redondo, FJ Sjostrom, M Slowikowska-Hilczer, J Slusarczyk, P Smeeth, L Snijder, MB Solfrizzi, V Aris, T Sonestedt, E Soumare, A Staessen, JA Ferguson, TS Steene-Johannessen, J Stehle, P Stein, AD Stessman, J Stöckl, D Stokwiszewski, J Strufaldi, MW Arlappa, N Sun, CA Sundström, J Fernández-Bergés, D Suriyawongpaisal, P Sy, RG Tai, ES Tarawneh, M Tarqui-Mamani, CB Thijs, L Tolstrup, JS Topbas, M Arveiler, D Torrent, M Bixby, H Traissac, P Trinh, OT Tulloch-Reid, MK Tuomainen, TP Turley, ML Tzourio, C Ueda, P Ukoli, FM Ulmer, H Assah, FK Ferrari, M Valdivia, G van Valkengoed, IG Vanderschueren, D Vanuzzo, D Vega, T Velasquez-Melendez, G Veronesi, G Verschuren, M Vioque, J Virtanen, J Ferreccio, C Avdicová, M Visvikis-Siest, S Viswanathan, B Vollenweider, P Voutilainen, S Wade, AN Wagner, A Walton, J Mohamud, WN Wang, MD Finn, JD Wang, YX Balakrishna, N Wannamethee, SG Weerasekera, D Whincup, PH Widhalm, K Wiecek, A Wilks, RJ Willeit, J Wojtyniak, B Föger, B Wong, TY Woo, J Bandosz, P Woodward, M Wu, AG Wu, FC Wu, SL Xu, H Yang, X Ye, X Foo, LH Yoshihara, A Younger-Coleman, NO Zambon, S Barbagallo, CM Zargar, AH Zdrojewski, T Zhao, W Zheng, Y Barceló, A Batieha, AM Fouad, HM Baur, LA Ben Romdhane, H Bernabe-Ortiz, A Bhargava, SK Bi, Y Bjerregaard, P Björkelund, C Blake, M Blokstra, A Bo, S Francis, DK Boehm, BO Boissonnet, CP Bovet, P Brajkovich, I Breckenkamp, J Brewster, LM Brian, GR Bruno, G Bugge, A Cabrera de León, A Franco Mdo, C Can, G Cândido, AP Capuano, V Carvalho, M. J. Casanueva, FF Caserta, CA Castetbon, K Chamukuttan, S Chaturvedi, N Chen, CJ Frontera, G Chen, F Chen, S Cheng, CY Chetrit, A Chiou, ST Cho, Y Chudek, J Cifkova, R Claessens, F Concin, H Furusawa, T Cooper, C Cooper, R Costanzo, S Cottel, D Cowell, C Crujeiras, AB D'Arrigo, G Dallongeville, J Dankner, R Dauchet, L de Gaetano, G De Henauw, S Deepa, M Dehghan, A Gaciong, Z Galbarczyk, A Garnett, SP Gaspoz, JM Gasull, M Gates, L Geleijnse, JM Ghasemain, A Giampaoli, S Gianfagna, F Giovannelli, J Gonzalez Gross, M González Rivas, JP Gorbea, MB Gottrand, F Grant, JF Grodzicki, T Grøntved, A Gruden, G Gu, D Guan, OP Guerrero, R Guessous, I Guimaraes, AL Gutierrez, L Hardy, R Hari Kumar, R Heidemann, C Hihtaniemi, IT Ho, SY Ho, SC Hofman, A Horimoto, AR Hormiga, CM Horta, BL Houti, L Hussieni, AS Huybrechts, I Hwalla, N Iacoviello, L Stevens, GA Iannone, AG Ibrahim, MM Ikeda, N Ikram, MA Irazola, VE Islam, M Iwasaki, M Jacobs, JM Jafar, T Jasienska, G Riley, LM Jiang, CQ |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
DigitUMa |
dc.contributor.author.fl_str_mv |
Danaei, G Fahimi, S Lu, Y Zhou, B Hajifathalian, K Di Cesare, M Lo, WC Reis-Santos, B Cowan, MJ Shaw, JE Bentham, J Jonas, JB Joshi, P Kafatos, A Kalter-Leibovici, O Kasaeian, A Katz, J Kaur, P Kavousi, M Kelishadi, R Ali, MK Dhana, K Kengne, AP Kersting, M Khader, YS Khang, YH Kiechl, S Kim, J Kiyohara, Y Kolsteren, P Korrovits, P Koskinen, S Di Castelnuovo, AF Ezzati, M Kratzer, W Kromhout, D Kula, K Kurjata, P Kyobutungi, C Lachat, C Laid, Y Lam, TH Lanska, V Djalalinia, S Lappas, G Abdeen, ZA Laxmaiah, A Leclercq, C Lee, J Lee, J Lehtimäki, T Lekhraj, R León-Muñoz, LM Li, Y Doua, K Lim, WY Lima-Costa, MF Kadir, KA Lin, HH Lin, X Lissner, L Lorbeer, R Lozano, JE Lundqvist, A Lytsy, P Drygas, W Ma, G Machado-Coelho, GL Machi, S Abu-Rmeileh, M Maggi, S Magliano, D Makdisse, M Mallikharjuna v, K Manios, Y Manzato, E Du, Y Margozzini, P Marques-Vidal, P Martorell, R Masoodi, SR Acosta-Cazares, B Matsha, TE Mbanya, JC McFarlane, SR McGarvey, ST McLachlan, S Egbagbe, EE McNulty, BA Mediene-Benchekor, S Meirhaeghe, A Menezes, AM Merat, S Aekplakorn, W Meshram, II Mi, J Miquel, JF Miranda, JJ Eggertsen, R Mohamed, MK Mohammad, K Mohan, V Mohd Yusoff, MF Møller, NC Molnar, D Aguilar-Salinas, CA Mondo, CK Moreno, LA Morgan, K El Ati, J Moschonis, G Mossakowska, M Mostafa, A Mota, J Muiesan, ML Müller-Nurasyid, M Mursu, J Ahmadvand, A Nagel, G Námešná, J Elosua, R Nang, EE Nangia, VB Navarrete-Muñoz, EM Ndiaye, NC Nervi, F Nguyen, ND Nieto-Martínez, RE Alvarado, L Al Nsour, M Ning, G Lin, JK Ninomiya, T Noale, M Noto, D Ochoa-Avilés, M Oh, K Onat, A Osmond, C Otero, JA Palmieri, L Alkerwi, A Erasmus, RT Panda-Jonas, S Panza, F Parsaeian, M Peixoto, SV Pereira, AC Peters, A Peykari, N Pilav, A Pitakaka, F Piwonska, A Erem, C Amouyel, P Piwonski, J Plans-Rubió, P Porta, M Portegies, ML Poustchi, H Pradeepa, R Price, JF Punab, M Qasrawi, RF Ergor, G Qorbani, M Andersen, L. B. Raitakari, O Ramachandra Rao, S Ramachandran, A Ramos, R Rampal, S Rathmann, W Redon, J Reganit, PF Eriksen, L Rigo, F Robinson, SM Anderssen, S. A. Robitaille, C Rodríguez, LA Rodríguez-Artalejo, F del Cristo Rodriguez-Perez, M Rojas-Martinez, R Romaguera, D Rosengren, A Escobedo-de la Peña, J Rubinstein, A Ornelas, Rui Ruiz-Betancourt, BS Andrade, DS Rutkowski, M Sabanayagam, C Sachdev, HS Saidi, O Sakarya, S Salanave, B Fall, CH Salonen, JT Salvetti, M Sánchez-Abanto, J Santos, RN Anjana, RM Santos, R Sardinha, LB Scazufca, M Schargrodsky, H Scheidt-Nave, C Farzadfar, F Shaw, JE Shibuya, K Shin, Y Shiri, R Siantar, R Aounallah-Skhiri, H Sibai, AM Simon, M Simons, J Simons, LA Felix-Redondo, FJ Sjostrom, M Slowikowska-Hilczer, J Slusarczyk, P Smeeth, L Snijder, MB Solfrizzi, V Aris, T Sonestedt, E Soumare, A Staessen, JA Ferguson, TS Steene-Johannessen, J Stehle, P Stein, AD Stessman, J Stöckl, D Stokwiszewski, J Strufaldi, MW Arlappa, N Sun, CA Sundström, J Fernández-Bergés, D Suriyawongpaisal, P Sy, RG Tai, ES Tarawneh, M Tarqui-Mamani, CB Thijs, L Tolstrup, JS Topbas, M Arveiler, D Torrent, M Bixby, H Traissac, P Trinh, OT Tulloch-Reid, MK Tuomainen, TP Turley, ML Tzourio, C Ueda, P Ukoli, FM Ulmer, H Assah, FK Ferrari, M Valdivia, G van Valkengoed, IG Vanderschueren, D Vanuzzo, D Vega, T Velasquez-Melendez, G Veronesi, G Verschuren, M Vioque, J Virtanen, J Ferreccio, C Avdicová, M Visvikis-Siest, S Viswanathan, B Vollenweider, P Voutilainen, S Wade, AN Wagner, A Walton, J Mohamud, WN Wang, MD Finn, JD Wang, YX Balakrishna, N Wannamethee, SG Weerasekera, D Whincup, PH Widhalm, K Wiecek, A Wilks, RJ Willeit, J Wojtyniak, B Föger, B Wong, TY Woo, J Bandosz, P Woodward, M Wu, AG Wu, FC Wu, SL Xu, H Yang, X Ye, X Foo, LH Yoshihara, A Younger-Coleman, NO Zambon, S Barbagallo, CM Zargar, AH Zdrojewski, T Zhao, W Zheng, Y Barceló, A Batieha, AM Fouad, HM Baur, LA Ben Romdhane, H Bernabe-Ortiz, A Bhargava, SK Bi, Y Bjerregaard, P Björkelund, C Blake, M Blokstra, A Bo, S Francis, DK Boehm, BO Boissonnet, CP Bovet, P Brajkovich, I Breckenkamp, J Brewster, LM Brian, GR Bruno, G Bugge, A Cabrera de León, A Franco Mdo, C Can, G Cândido, AP Capuano, V Carvalho, M. J. Casanueva, FF Caserta, CA Castetbon, K Chamukuttan, S Chaturvedi, N Chen, CJ Frontera, G Chen, F Chen, S Cheng, CY Chetrit, A Chiou, ST Cho, Y Chudek, J Cifkova, R Claessens, F Concin, H Furusawa, T Cooper, C Cooper, R Costanzo, S Cottel, D Cowell, C Crujeiras, AB D'Arrigo, G Dallongeville, J Dankner, R Dauchet, L Magliano, D de Gaetano, G De Henauw, S Deepa, M Dehghan, A Gaciong, Z Galbarczyk, A Garnett, SP Gaspoz, JM Gasull, M Gates, L Geleijnse, JM Ghasemain, A Giampaoli, S Gianfagna, F Bovet, P Giovannelli, J Gonzalez Gross, M González Rivas, JP Gorbea, MB Gottrand, F Grant, JF Grodzicki, T Grøntved, A Gruden, G Gu, D Miranda, JJ Guan, OP Guerrero, R Guessous, I Guimaraes, AL Gutierrez, L Hardy, R Hari Kumar, R Heidemann, C Hihtaniemi, IT Ho, SY Khang, YH Ho, SC Hofman, A Horimoto, AR Hormiga, CM Horta, BL Houti, L Hussieni, AS Huybrechts, I Hwalla, N Iacoviello, L Stevens, GA Iannone, AG Ibrahim, MM Ikeda, N Ikram, MA Irazola, VE Islam, M Iwasaki, M Jacobs, JM Jafar, T Jasienska, G Riley, LM Jiang, CQ |
dc.subject.por.fl_str_mv |
Diabetes Effects of diabetes Diabetes prevalence Diabetes diagnosis Global surveillance of diabetes . Faculdade de Ciências Sociais |
topic |
Diabetes Effects of diabetes Diabetes prevalence Diabetes diagnosis Global surveillance of diabetes . Faculdade de Ciências Sociais |
description |
Background Diabetes has been defi ned on the basis of diff erent biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the eff ect of diff erent diagnostic defi nitions on both the population prevalence of diabetes and the classifi cation of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in diff erent regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defi ning diabetes. Diabetes was defi ned using HbA1c (HbA1c ≥6·5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT defi nitions (FPG ≥7·0 mmol/L or 2hOGTT ≥11·1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using diff erent defi nitions graphically and by regression analyses. We calculated sensitivity and specifi city of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specifi city in each survey, and then pooled results using a random-eff ects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG-or-2hOGTT was correlated with prevalence based on FPG alone (r=0·98), but was higher by 2–6 percentage points at diff erent prevalence levels. Prevalence based on HbA1c was lower than prevalence based on FPG in 42·8% of age–sex–survey groups and higher in another 41·6%; in the other 15·6%, the two defi nitions provided similar prevalence estimates. The variation across studies in the relation between glucose-based and HbA1c-based prevalences was partly related to participants’ age, followed by natural logarithm of per person gross domestic product, the year of survey, mean BMI, and whether the survey population was national, subnational, or from specifi c communities. Diabetes defi ned as HbA1c 6·5% or more had a pooled sensitivity of 52·8% (95% CI 51·3–54·3%) and a pooled specifi city of 99·74% (99·71–99·78%) compared with FPG 7·0 mmol/L or more for diagnosing previously undiagnosed participants; sensitivity compared with diabetes defi ned based on FPG or-2hOGTT was 30·5% (28·7–32·3%). None of the preselected study-level characteristics explained the heterogeneity in the sensitivity of HbA1c versus FPG. Interpretation Diff erent biomarkers and defi nitions for diabetes can provide diff erent estimates of population prevalence of diabetes, and diff erentially identify people without previous diagnosis as having diabetes. Using an HbA1c-based defi nition alone in health surveys will not identify a substantial proportion of previously undiagnosed people who would be considered as having diabetes using a glucose-based test. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01T00:00:00Z 2015-01-01T00:00:00Z 2021-11-23T15:34:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.13/3846 |
url |
http://hdl.handle.net/10400.13/3846 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Danaei, G., Fahimi, S., Lu, Y., Zhou, B., Hajifathalian, K., Di Cesare, M., ... & Guan, O. P. (2015). Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants. The Lancet Diabetes & Endocrinology, 3(8), 624-637. https://doi.org/10.1016/S2213-8587(15)00129-1 10.1016/S2213-8587(15)00129-1 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799129942918692864 |