Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal

Detalhes bibliográficos
Autor(a) principal: Lucaccioni, Héloïse
Data de Publicação: 2021
Outros Autores: Sá Machado, Rita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706
Resumo: Introduction: Rotavirus infections are a leading cause of severe acute gastroenteritis in children under five years old. In December 2019, Portugal announced the inclusion of the rotavirus vaccine, already available for private purchase, in the National Immunization Program. We present the first nationwide analysis of the burden and trends of rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal (2014 - 2017).Material and Methods: We used the hospital morbidity database and the Death Certificate Information System to identify hospital episodes and deaths of rotavirus and acute gastroenteritis based on the codes of the International Classification of Diseases. We described the number and rates of hospital episodes disaggregated by age group, sex, geographical units, and the seasonality and trends over the study period.Results: On average, during the study period, there were 1985 annual hospital episodes among children under five years old. The annual rate was 48.0/10 000 children (95% CI 46.9 - 49.0). Rates were consistently higher in younger children, and 67.8% episodes occurred in children under 24 months. We found a seasonal pattern with a major peak in the early spring.Discussion: Our results were consistent with the current knowledge on rotavirus and acute gastroenteritis hospital episodes in Europe. Additional studies are needed to identify the risk factors and high-risk groups for hospital attendance.Conclusion: Rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal represent an important health and economic burden. In the future, monitoring this burden and these trends in relation with rotavirus vaccine coverage could be useful in order to assess the impact of the vaccination programme on the change in hospital episodes.
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spelling Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland PortugalCarga e Tendências dos Episódios Hospitalares de Infeções Graves por Rotavírus e Gastroenterite Aguda Grave em Crianças com Menos de Cinco Anos, em Portugal ContinentalChildGastroenteritisHospitalizationPortugalRotavirus InfectionsRotavirus VaccinesGastroenteriteHospitalizaçãoInfecções por RotavirusPortugalVacinas contra RotavirusIntroduction: Rotavirus infections are a leading cause of severe acute gastroenteritis in children under five years old. In December 2019, Portugal announced the inclusion of the rotavirus vaccine, already available for private purchase, in the National Immunization Program. We present the first nationwide analysis of the burden and trends of rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal (2014 - 2017).Material and Methods: We used the hospital morbidity database and the Death Certificate Information System to identify hospital episodes and deaths of rotavirus and acute gastroenteritis based on the codes of the International Classification of Diseases. We described the number and rates of hospital episodes disaggregated by age group, sex, geographical units, and the seasonality and trends over the study period.Results: On average, during the study period, there were 1985 annual hospital episodes among children under five years old. The annual rate was 48.0/10 000 children (95% CI 46.9 - 49.0). Rates were consistently higher in younger children, and 67.8% episodes occurred in children under 24 months. We found a seasonal pattern with a major peak in the early spring.Discussion: Our results were consistent with the current knowledge on rotavirus and acute gastroenteritis hospital episodes in Europe. Additional studies are needed to identify the risk factors and high-risk groups for hospital attendance.Conclusion: Rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal represent an important health and economic burden. In the future, monitoring this burden and these trends in relation with rotavirus vaccine coverage could be useful in order to assess the impact of the vaccination programme on the change in hospital episodes.Introdução: As infeções por rotavírus são uma das principais causas de gastroenterite aguda grave em crianças com menos de cinco anos. Em dezembro de 2019, foi anunciada a inclusão da vacina contra rotavírus, já disponível no mercado privado, no Programa Nacional de Vacinação. Esta é a primeira análise nacional da carga e tendência dos episódios hospitalares de rotavírus e gastroenterite aguda grave em crianças com menos de cinco anos em Portugal continental (2014 - 2017).Material e Métodos: Utilizou-se a base de dados de morbilidade hospitalar e o sistema de informação de certificados de óbito para identificar episódios hospitalares e mortes por rotavírus e gastroenterite aguda grave, a partir de códigos da classificação internacional de doenças. Descreveu-se o número e as taxas de episódios hospitalares, desagregadas por grupo etário, sexo, geografia, e a sazonalidade e tendências ao longo do período em estudo.Resultados: Em média, houve 1985 episódios hospitalares anuais em crianças com menos de cinco anos. A taxa anual foi de 48,0/ 10 000 crianças (95% IC 46,9 - 49,0). A taxa de hospitalização foi consistentemente mais elevada em crianças mais jovens, e 67,8% dos episódios ocorreram em crianças com menos de 24 meses. Relativamente à sazonalidade, encontrámos um pico no início da Primavera.Discussão: Os resultados foram consistentes com os conhecimentos atuais sobre rotavírus e episódios hospitalares de gastroenteriteaguda grave na Europa. São necessários estudos adicionais para identificar os fatores e grupos de risco de infeções graves.Conclusão: Em Portugal Continental, os episódios hospitalares de rotavírus e gastroenterite aguda grave em crianças de idade inferior a cinco anos têm um impacto negativo relevante na saúde e na economia. No futuro, e na perspetiva da introdução da vacinação para o rotavírus, estes indicadores serão relevantes para monitorizar o impacto do programa de vacinação na diminuição dos episódios hospitalares.Ordem dos Médicos2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfimage/jpegimage/jpegimage/jpegapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706oai:ojs.www.actamedicaportuguesa.com:article/15706Acta Médica Portuguesa; Vol. 34 No. 10 (2021): Outubro; 669-676Acta Médica Portuguesa; Vol. 34 N.º 10 (2021): Outubro; 669-6761646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/6293https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/6294https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/6295https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/13171https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/13172https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/13173https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/13174https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/13175https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15706/13354Direitos de Autor (c) 2021 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessLucaccioni, HéloïseSá Machado, Rita2022-12-20T11:07:36Zoai:ojs.www.actamedicaportuguesa.com:article/15706Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:40.302078Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
Carga e Tendências dos Episódios Hospitalares de Infeções Graves por Rotavírus e Gastroenterite Aguda Grave em Crianças com Menos de Cinco Anos, em Portugal Continental
title Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
spellingShingle Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
Lucaccioni, Héloïse
Child
Gastroenteritis
Hospitalization
Portugal
Rotavirus Infections
Rotavirus Vaccines
Gastroenterite
Hospitalização
Infecções por Rotavirus
Portugal
Vacinas contra Rotavirus
title_short Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
title_full Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
title_fullStr Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
title_full_unstemmed Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
title_sort Burden and Trends of Severe Rotavirus Infections and Allcause Acute Gastroenteritis Hospital Episodes in Children Under Five Years Old in Mainland Portugal
author Lucaccioni, Héloïse
author_facet Lucaccioni, Héloïse
Sá Machado, Rita
author_role author
author2 Sá Machado, Rita
author2_role author
dc.contributor.author.fl_str_mv Lucaccioni, Héloïse
Sá Machado, Rita
dc.subject.por.fl_str_mv Child
Gastroenteritis
Hospitalization
Portugal
Rotavirus Infections
Rotavirus Vaccines
Gastroenterite
Hospitalização
Infecções por Rotavirus
Portugal
Vacinas contra Rotavirus
topic Child
Gastroenteritis
Hospitalization
Portugal
Rotavirus Infections
Rotavirus Vaccines
Gastroenterite
Hospitalização
Infecções por Rotavirus
Portugal
Vacinas contra Rotavirus
description Introduction: Rotavirus infections are a leading cause of severe acute gastroenteritis in children under five years old. In December 2019, Portugal announced the inclusion of the rotavirus vaccine, already available for private purchase, in the National Immunization Program. We present the first nationwide analysis of the burden and trends of rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal (2014 - 2017).Material and Methods: We used the hospital morbidity database and the Death Certificate Information System to identify hospital episodes and deaths of rotavirus and acute gastroenteritis based on the codes of the International Classification of Diseases. We described the number and rates of hospital episodes disaggregated by age group, sex, geographical units, and the seasonality and trends over the study period.Results: On average, during the study period, there were 1985 annual hospital episodes among children under five years old. The annual rate was 48.0/10 000 children (95% CI 46.9 - 49.0). Rates were consistently higher in younger children, and 67.8% episodes occurred in children under 24 months. We found a seasonal pattern with a major peak in the early spring.Discussion: Our results were consistent with the current knowledge on rotavirus and acute gastroenteritis hospital episodes in Europe. Additional studies are needed to identify the risk factors and high-risk groups for hospital attendance.Conclusion: Rotavirus and acute gastroenteritis hospital episodes in children under five years old in mainland Portugal represent an important health and economic burden. In the future, monitoring this burden and these trends in relation with rotavirus vaccine coverage could be useful in order to assess the impact of the vaccination programme on the change in hospital episodes.
publishDate 2021
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dc.rights.driver.fl_str_mv Direitos de Autor (c) 2021 Acta Médica Portuguesa
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 34 No. 10 (2021): Outubro; 669-676
Acta Médica Portuguesa; Vol. 34 N.º 10 (2021): Outubro; 669-676
1646-0758
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