Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest

Detalhes bibliográficos
Autor(a) principal: Rambabu, D.
Data de Publicação: 2013
Outros Autores: Kumar, G. Pavan, Kumar, Barange Deepak, Kapavarapu, Ravikumar, Rao, M. V. Basaveswara, Pal, Manojit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/27430
https://doi.org/10.1016/j.tetlet.2013.03.121
Resumo: The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C–Et3N–CuI–PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest.
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spelling Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interestAlkynesPd/CCoupling3-AlkylidenephthalidesThe coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C–Et3N–CuI–PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest.Elsevier2013-06-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/27430http://hdl.handle.net/10316/27430https://doi.org/10.1016/j.tetlet.2013.03.121engRAMBABU, D. [et. al] - Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest. "Tetrahedron Letters". ISSN 0040-4039. Vol. 54 Nº. 23 (2013) p. 2989-29950040-4039http://www.sciencedirect.com/science/article/pii/S0040403913005480Rambabu, D.Kumar, G. PavanKumar, Barange DeepakKapavarapu, RavikumarRao, M. V. BasaveswaraPal, Manojitinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T12:16:35Zoai:estudogeral.uc.pt:10316/27430Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:36.183697Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
title Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
spellingShingle Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
Rambabu, D.
Alkynes
Pd/C
Coupling
3-Alkylidenephthalides
title_short Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
title_full Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
title_fullStr Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
title_full_unstemmed Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
title_sort Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
author Rambabu, D.
author_facet Rambabu, D.
Kumar, G. Pavan
Kumar, Barange Deepak
Kapavarapu, Ravikumar
Rao, M. V. Basaveswara
Pal, Manojit
author_role author
author2 Kumar, G. Pavan
Kumar, Barange Deepak
Kapavarapu, Ravikumar
Rao, M. V. Basaveswara
Pal, Manojit
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rambabu, D.
Kumar, G. Pavan
Kumar, Barange Deepak
Kapavarapu, Ravikumar
Rao, M. V. Basaveswara
Pal, Manojit
dc.subject.por.fl_str_mv Alkynes
Pd/C
Coupling
3-Alkylidenephthalides
topic Alkynes
Pd/C
Coupling
3-Alkylidenephthalides
description The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C–Et3N–CuI–PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-05
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/27430
http://hdl.handle.net/10316/27430
https://doi.org/10.1016/j.tetlet.2013.03.121
url http://hdl.handle.net/10316/27430
https://doi.org/10.1016/j.tetlet.2013.03.121
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv RAMBABU, D. [et. al] - Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest. "Tetrahedron Letters". ISSN 0040-4039. Vol. 54 Nº. 23 (2013) p. 2989-2995
0040-4039
http://www.sciencedirect.com/science/article/pii/S0040403913005480
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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