Alginate based scaffolds for bone tissue engineering

Detalhes bibliográficos
Autor(a) principal: Valente, Joana
Data de Publicação: 2012
Outros Autores: Valente, Tiago António Martins, Alves, Patrícia, Ferreira, Paula, Silva, Abílio, Correia, I.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4634
Resumo: The design and production of scaffolds for bone tissue regeneration is yet unable to completely reproduce the native bone properties. In the present study new alginate microparticle and microfiber aggregated scaffolds were produced to be applied in this area of regenerative medicine. The scaffolds' mechanical properties were characterized by thermo mechanical assays. Their morphological characteristics were evaluated by isothermal nitrogen adsorption and scanning electron microscopy. The density of both types of scaffolds was determined by helium pycnometry and mercury intrusion porosimetry. Furthermore, scaffolds' cytotoxic profiles were evaluated in vitro by seeding human osteoblast cells in their presence. The results obtained showed that scaffolds have good mechanical and morphological properties compatible with their application as bone substitutes. Moreover, scaffold's biocompatibility was confirmed by the observation of cell adhesion and proliferation after 5 days of being seeded in their presence and by non-radioactive assays.
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spelling Alginate based scaffolds for bone tissue engineering3D scaffoldsBiocompatibilityBiomaterialsBone Tissue EngineeringIn vitro studiesThe design and production of scaffolds for bone tissue regeneration is yet unable to completely reproduce the native bone properties. In the present study new alginate microparticle and microfiber aggregated scaffolds were produced to be applied in this area of regenerative medicine. The scaffolds' mechanical properties were characterized by thermo mechanical assays. Their morphological characteristics were evaluated by isothermal nitrogen adsorption and scanning electron microscopy. The density of both types of scaffolds was determined by helium pycnometry and mercury intrusion porosimetry. Furthermore, scaffolds' cytotoxic profiles were evaluated in vitro by seeding human osteoblast cells in their presence. The results obtained showed that scaffolds have good mechanical and morphological properties compatible with their application as bone substitutes. Moreover, scaffold's biocompatibility was confirmed by the observation of cell adhesion and proliferation after 5 days of being seeded in their presence and by non-radioactive assays.uBibliorumValente, JoanaValente, Tiago António MartinsAlves, PatríciaFerreira, PaulaSilva, AbílioCorreia, I.J.2018-03-19T14:20:44Z2012-08-122012-08-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4634engValente, J., Valente, T.A.M., Alves, P., Ferreira, P., Silva, A.P. e Correia, I.J. (2012) "Alginate based scaffolds for bone tissue engineering", Materials Science & Engineering C - Materials for Biological Applications, Vol. 32(8), pp. 2596-260310.1016/j.msec.2012.08.001metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:45Zoai:ubibliorum.ubi.pt:10400.6/4634Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:41.817818Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Alginate based scaffolds for bone tissue engineering
title Alginate based scaffolds for bone tissue engineering
spellingShingle Alginate based scaffolds for bone tissue engineering
Valente, Joana
3D scaffolds
Biocompatibility
Biomaterials
Bone Tissue Engineering
In vitro studies
title_short Alginate based scaffolds for bone tissue engineering
title_full Alginate based scaffolds for bone tissue engineering
title_fullStr Alginate based scaffolds for bone tissue engineering
title_full_unstemmed Alginate based scaffolds for bone tissue engineering
title_sort Alginate based scaffolds for bone tissue engineering
author Valente, Joana
author_facet Valente, Joana
Valente, Tiago António Martins
Alves, Patrícia
Ferreira, Paula
Silva, Abílio
Correia, I.J.
author_role author
author2 Valente, Tiago António Martins
Alves, Patrícia
Ferreira, Paula
Silva, Abílio
Correia, I.J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Valente, Joana
Valente, Tiago António Martins
Alves, Patrícia
Ferreira, Paula
Silva, Abílio
Correia, I.J.
dc.subject.por.fl_str_mv 3D scaffolds
Biocompatibility
Biomaterials
Bone Tissue Engineering
In vitro studies
topic 3D scaffolds
Biocompatibility
Biomaterials
Bone Tissue Engineering
In vitro studies
description The design and production of scaffolds for bone tissue regeneration is yet unable to completely reproduce the native bone properties. In the present study new alginate microparticle and microfiber aggregated scaffolds were produced to be applied in this area of regenerative medicine. The scaffolds' mechanical properties were characterized by thermo mechanical assays. Their morphological characteristics were evaluated by isothermal nitrogen adsorption and scanning electron microscopy. The density of both types of scaffolds was determined by helium pycnometry and mercury intrusion porosimetry. Furthermore, scaffolds' cytotoxic profiles were evaluated in vitro by seeding human osteoblast cells in their presence. The results obtained showed that scaffolds have good mechanical and morphological properties compatible with their application as bone substitutes. Moreover, scaffold's biocompatibility was confirmed by the observation of cell adhesion and proliferation after 5 days of being seeded in their presence and by non-radioactive assays.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-12
2012-08-12T00:00:00Z
2018-03-19T14:20:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4634
url http://hdl.handle.net/10400.6/4634
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Valente, J., Valente, T.A.M., Alves, P., Ferreira, P., Silva, A.P. e Correia, I.J. (2012) "Alginate based scaffolds for bone tissue engineering", Materials Science & Engineering C - Materials for Biological Applications, Vol. 32(8), pp. 2596-2603
10.1016/j.msec.2012.08.001
dc.rights.driver.fl_str_mv metadata only access
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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