THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK?
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.58043/rphrc.60 |
Resumo: | Introduction: Thiazide diuretics are first-line drugs in the treatment of arterial hypertension. Due to its photosensitizing properties, it remains unclear whether its prolonged use increases the risk of skin cancer. Aim: To evaluate the possible association between the use of thiazide diuretics and the diagnosis of skin cancer. Methodology: Research in major online medical databases, with MeSH terms “thiazide diuretics” AND “skin cancer”, with no population restrictions except medication with thiazide diuretics. The comparator was the absence of thiazide/ administration of placebo/other antihypertensive and the outcome was of skin cancer. Results: 13 articles were included – 3 retrospective cohorts, 1 prospective cohort, 6 case-control studies and 3 meta-analyses. 9 studies reported an association between the use of thiazides and the development of skin cancer, namely melanoma, squamous cell carcinoma and basal cell carcinoma. Several authors report a clear dose-response relationship between the use of hydrochlorothiazide and the incidence of basal and squamous cell carcinoma. The remaining studies do not support this relationship remaining a controversial issue. Conclusion: These results should be analyzed carefully, since, although there is a statistically significant relationship between the risk of developing skin cancer and the administration of thiazide diuretics, this risk is low, so these drugs should not be discontinued when their antihypertensive benefit is evident and greater than the potential risk. |
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THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK?DIURÉTICOS TIAZÍDICOS E CANCRO DE PELE – UM RISCO REAL?Introduction: Thiazide diuretics are first-line drugs in the treatment of arterial hypertension. Due to its photosensitizing properties, it remains unclear whether its prolonged use increases the risk of skin cancer. Aim: To evaluate the possible association between the use of thiazide diuretics and the diagnosis of skin cancer. Methodology: Research in major online medical databases, with MeSH terms “thiazide diuretics” AND “skin cancer”, with no population restrictions except medication with thiazide diuretics. The comparator was the absence of thiazide/ administration of placebo/other antihypertensive and the outcome was of skin cancer. Results: 13 articles were included – 3 retrospective cohorts, 1 prospective cohort, 6 case-control studies and 3 meta-analyses. 9 studies reported an association between the use of thiazides and the development of skin cancer, namely melanoma, squamous cell carcinoma and basal cell carcinoma. Several authors report a clear dose-response relationship between the use of hydrochlorothiazide and the incidence of basal and squamous cell carcinoma. The remaining studies do not support this relationship remaining a controversial issue. Conclusion: These results should be analyzed carefully, since, although there is a statistically significant relationship between the risk of developing skin cancer and the administration of thiazide diuretics, this risk is low, so these drugs should not be discontinued when their antihypertensive benefit is evident and greater than the potential risk.Introdução: Os diuréticos tiazídicos são fármacos de primeira linha no tratamento da hipertensão arterial. Pelas suas propriedades fotossensibilizantes, permanece por esclarecer se o seu uso prolongado aumenta o risco de cancro de pele. Objetivo: avaliar a possível associação entre o uso de diuréticos tiazídicos e o diagnóstico de cancro de pele. Metodologia: Pesquisa bibliográfica nas principais bases de dados médicas online, com os termos MeSH “thiazide diuretics” AND “skin cancer”, sem restrições à população exceto medicação com diuréticos tiazídicos. O comparador foi a ausência de tiazida/administração de placebo/outro anti-hipertensor e o outcome cancro de pele. Resultados: Foram incluídos 13 artigos – 3 cohort retrospetivas, 1 cohort prospetiva, 6 estudos caso-controlo e 3 meta-análises. 9 estudos reportam associação entre o uso de tiazidas e o desenvolvimento de cancro de pele, nomeadamente melanoma, carcinoma espinho-celular e carcinoma basocelular. Vários autores reportam uma evidente relação dose-resposta entre a utilização de hidroclorotiazida e a incidência de carcinoma baso e espinhocelular. Os restantes estudos não corroboram esta relação, permanecendo um tema controverso. Conclusão: A interpretação destes resultados deve ser cautelosa, já que, apesar de existir uma relação estatisticamente significativa de risco de desenvolver cancro de pele com o uso diário de diuréticos tiazídicos, este risco é baixo, não devendo estes fármacos deixar de ser utilizados quando o seu benefício anti-hipertensivo é evidente e superior ao potencial risco.Revista Portuguesa de Hipertensão e Risco Cardiovascular2023-01-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.58043/rphrc.60https://doi.org/10.58043/rphrc.60Revista Portuguesa de Hipertensão e Risco Cardiovascular; N.º 92 (2022): Novembro/Dezembro; 25-291646-8287reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revistahipertensao.pt/index.php/rh/article/view/60https://revistahipertensao.pt/index.php/rh/article/view/60/54Lourenço, RitaRadamovschi, VictoriaPinto, Luísinfo:eu-repo/semantics/openAccess2024-02-03T07:36:49Zoai:ojs.revistahipertensao.pt:article/60Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:46:09.189498Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? DIURÉTICOS TIAZÍDICOS E CANCRO DE PELE – UM RISCO REAL? |
title |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? |
spellingShingle |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? Lourenço, Rita |
title_short |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? |
title_full |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? |
title_fullStr |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? |
title_full_unstemmed |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? |
title_sort |
THIAZIDE DIURETICS AND SKIN CANCER – A REAL RISK? |
author |
Lourenço, Rita |
author_facet |
Lourenço, Rita Radamovschi, Victoria Pinto, Luís |
author_role |
author |
author2 |
Radamovschi, Victoria Pinto, Luís |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Lourenço, Rita Radamovschi, Victoria Pinto, Luís |
description |
Introduction: Thiazide diuretics are first-line drugs in the treatment of arterial hypertension. Due to its photosensitizing properties, it remains unclear whether its prolonged use increases the risk of skin cancer. Aim: To evaluate the possible association between the use of thiazide diuretics and the diagnosis of skin cancer. Methodology: Research in major online medical databases, with MeSH terms “thiazide diuretics” AND “skin cancer”, with no population restrictions except medication with thiazide diuretics. The comparator was the absence of thiazide/ administration of placebo/other antihypertensive and the outcome was of skin cancer. Results: 13 articles were included – 3 retrospective cohorts, 1 prospective cohort, 6 case-control studies and 3 meta-analyses. 9 studies reported an association between the use of thiazides and the development of skin cancer, namely melanoma, squamous cell carcinoma and basal cell carcinoma. Several authors report a clear dose-response relationship between the use of hydrochlorothiazide and the incidence of basal and squamous cell carcinoma. The remaining studies do not support this relationship remaining a controversial issue. Conclusion: These results should be analyzed carefully, since, although there is a statistically significant relationship between the risk of developing skin cancer and the administration of thiazide diuretics, this risk is low, so these drugs should not be discontinued when their antihypertensive benefit is evident and greater than the potential risk. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-31 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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https://doi.org/10.58043/rphrc.60 https://doi.org/10.58043/rphrc.60 |
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https://doi.org/10.58043/rphrc.60 |
dc.language.iso.fl_str_mv |
por |
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por |
dc.relation.none.fl_str_mv |
https://revistahipertensao.pt/index.php/rh/article/view/60 https://revistahipertensao.pt/index.php/rh/article/view/60/54 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Revista Portuguesa de Hipertensão e Risco Cardiovascular |
publisher.none.fl_str_mv |
Revista Portuguesa de Hipertensão e Risco Cardiovascular |
dc.source.none.fl_str_mv |
Revista Portuguesa de Hipertensão e Risco Cardiovascular; N.º 92 (2022): Novembro/Dezembro; 25-29 1646-8287 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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