Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4641 |
Resumo: | Hematological paraneoplastic syndromes are fairly uncommon. While mild leukocytosis in solid tumors is well reported, white blood cell (WBC) count over 50,000 u/L, described as paraneoplastic leukemoid reaction (PLR), is not. Indeed, when found, it is usually associated with a higher burden of disease, tumor activity and worse clinical outcomes. We report the case of a challenging and burdensome diagnosis of a presumptive hematological paraneoplastic syndrome in a patient with a locally advanced lung cancer admitted in the Internal Medicine ward. After the end of chemotherapy, clinical and laboratory benefit was observed; however, the aggressive course of the disease became clear, with progression and downhill course that was unresponsive to treatment. |
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Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor PrognosisCHLC MEDHSAC ONCCHLC ANPATAntineoplastic Agents / therapeutic useCarcinoma / complications*Carcinoma / drug therapyFatal OutcomeHumansMaleMiddle AgedLung Neoplasms / complications*Lung Neoplasms / drug therapyParaneoplastic Syndromes / diagnosis*Paraneoplastic Syndromes / pathology*PrognosisHematological paraneoplastic syndromes are fairly uncommon. While mild leukocytosis in solid tumors is well reported, white blood cell (WBC) count over 50,000 u/L, described as paraneoplastic leukemoid reaction (PLR), is not. Indeed, when found, it is usually associated with a higher burden of disease, tumor activity and worse clinical outcomes. We report the case of a challenging and burdensome diagnosis of a presumptive hematological paraneoplastic syndrome in a patient with a locally advanced lung cancer admitted in the Internal Medicine ward. After the end of chemotherapy, clinical and laboratory benefit was observed; however, the aggressive course of the disease became clear, with progression and downhill course that was unresponsive to treatment.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEFerrão, JSardinha, MDutra, E2023-08-11T14:44:26Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4641engAm J Med Sci . 2021 Aug;362(2):211-21410.1016/j.amjms.2021.01.027info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-13T06:03:20Zoai:repositorio.chlc.min-saude.pt:10400.17/4641Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:26:58.257202Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
title |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
spellingShingle |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis Ferrão, J CHLC MED HSAC ONC CHLC ANPAT Antineoplastic Agents / therapeutic use Carcinoma / complications* Carcinoma / drug therapy Fatal Outcome Humans Male Middle Aged Lung Neoplasms / complications* Lung Neoplasms / drug therapy Paraneoplastic Syndromes / diagnosis* Paraneoplastic Syndromes / pathology* Prognosis |
title_short |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
title_full |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
title_fullStr |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
title_full_unstemmed |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
title_sort |
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis |
author |
Ferrão, J |
author_facet |
Ferrão, J Sardinha, M Dutra, E |
author_role |
author |
author2 |
Sardinha, M Dutra, E |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Ferrão, J Sardinha, M Dutra, E |
dc.subject.por.fl_str_mv |
CHLC MED HSAC ONC CHLC ANPAT Antineoplastic Agents / therapeutic use Carcinoma / complications* Carcinoma / drug therapy Fatal Outcome Humans Male Middle Aged Lung Neoplasms / complications* Lung Neoplasms / drug therapy Paraneoplastic Syndromes / diagnosis* Paraneoplastic Syndromes / pathology* Prognosis |
topic |
CHLC MED HSAC ONC CHLC ANPAT Antineoplastic Agents / therapeutic use Carcinoma / complications* Carcinoma / drug therapy Fatal Outcome Humans Male Middle Aged Lung Neoplasms / complications* Lung Neoplasms / drug therapy Paraneoplastic Syndromes / diagnosis* Paraneoplastic Syndromes / pathology* Prognosis |
description |
Hematological paraneoplastic syndromes are fairly uncommon. While mild leukocytosis in solid tumors is well reported, white blood cell (WBC) count over 50,000 u/L, described as paraneoplastic leukemoid reaction (PLR), is not. Indeed, when found, it is usually associated with a higher burden of disease, tumor activity and worse clinical outcomes. We report the case of a challenging and burdensome diagnosis of a presumptive hematological paraneoplastic syndrome in a patient with a locally advanced lung cancer admitted in the Internal Medicine ward. After the end of chemotherapy, clinical and laboratory benefit was observed; however, the aggressive course of the disease became clear, with progression and downhill course that was unresponsive to treatment. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08 2021-08-01T00:00:00Z 2023-08-11T14:44:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4641 |
url |
http://hdl.handle.net/10400.17/4641 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Am J Med Sci . 2021 Aug;362(2):211-214 10.1016/j.amjms.2021.01.027 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817553325840662528 |