Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications

Detalhes bibliográficos
Autor(a) principal: Batista, Elsa
Data de Publicação: 2022
Outros Autores: Álvares, Miguel, Martins, Rui F., Ogheard, Florestan, Geršl, Jan, Godinho, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/145853
Resumo: This work performed under 18HLT08 MeDDII project has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme. The Authors would like to acknowledge Abir Wissam Boudaoud for her help in CETIAT inner diameter measurements and Václav Duchoň and Petr Grolich from CMI for their work on the glass syringe diameter calibration. © 2022 the author(s), published by De Gruyter, Berlin/Boston.
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spelling Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applicationsThis work performed under 18HLT08 MeDDII project has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme. The Authors would like to acknowledge Abir Wissam Boudaoud for her help in CETIAT inner diameter measurements and Václav Duchoň and Petr Grolich from CMI for their work on the glass syringe diameter calibration. © 2022 the author(s), published by De Gruyter, Berlin/Boston.OBJECTIVES: Microflow measurement devices are used in several science and health applications, mainly drug delivery. In the last decade, several new methods based on optical technology were developed, namely the front tracking and interferometric method, in which the knowledge of the inner diameter of the syringe or the capillary used is critical. Only a few National Metrology Institutes (NMIs) can perform inner diameter measurements below 1 mm, which requires expensive technology. Therefore, IPQ, in cooperation with CETIAT, CMI and UNIDEMI, under the EMPIR project 18HLT08 MeDDII - Metrology for Drug Delivery, developed new measurement methods for small inner diameter tubes based on the gravimetric principle and optical methods in order to simplify the apparatus used for this type of measurements without increasing uncertainty. METHODS: The gravimetric experimental setup consists of measuring the liquid volume on a specific length of the glass tube. The optical method used is based on the front track principle that uses a high-resolution camera and ImageJ software, to determine the diameter at both ends of each capillary. RESULTS: To validate the developed methods, a comparison was performed between CETIAT, CMI and IPQ and the results obtained were all consistent. CONCLUSIONS: This work allowed the determination of inner diameter of syringes or capillaries using two different methods with relative expanded uncertainties from 0.1 to 0.5% ( k=2), that can be applied for flow measurements using optical technology.DEMI - Departamento de Engenharia Mecânica e IndustrialUNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e IndustrialRUNBatista, ElsaÁlvares, MiguelMartins, Rui F.Ogheard, FlorestanGeršl, JanGodinho, Isabel2022-11-28T22:15:32Z2023-02-012023-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/145853eng0013-5585PURE: 47748696https://doi.org/10.1515/bmt-2022-0033info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:32Zoai:run.unl.pt:10362/145853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:18.016558Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
title Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
spellingShingle Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
Batista, Elsa
title_short Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
title_full Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
title_fullStr Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
title_full_unstemmed Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
title_sort Measurement of internal diameters of capillaries and glass syringes using gravimetric and optical methods for microflow applications
author Batista, Elsa
author_facet Batista, Elsa
Álvares, Miguel
Martins, Rui F.
Ogheard, Florestan
Geršl, Jan
Godinho, Isabel
author_role author
author2 Álvares, Miguel
Martins, Rui F.
Ogheard, Florestan
Geršl, Jan
Godinho, Isabel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv DEMI - Departamento de Engenharia Mecânica e Industrial
UNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial
RUN
dc.contributor.author.fl_str_mv Batista, Elsa
Álvares, Miguel
Martins, Rui F.
Ogheard, Florestan
Geršl, Jan
Godinho, Isabel
description This work performed under 18HLT08 MeDDII project has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme. The Authors would like to acknowledge Abir Wissam Boudaoud for her help in CETIAT inner diameter measurements and Václav Duchoň and Petr Grolich from CMI for their work on the glass syringe diameter calibration. © 2022 the author(s), published by De Gruyter, Berlin/Boston.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-28T22:15:32Z
2023-02-01
2023-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145853
url http://hdl.handle.net/10362/145853
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0013-5585
PURE: 47748696
https://doi.org/10.1515/bmt-2022-0033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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