Applying science in practice: the optimization of biological therapy in rheumatoid arthritis

Detalhes bibliográficos
Autor(a) principal: Ramiro, S
Data de Publicação: 2010
Outros Autores: Machado, P, Singh, JA, Landewé, RB, Pereira da Silva, JA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/872
Resumo: Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review explores the application of published evidence to practice, discussing the goals of treatment, the (in) ability to predict individual responses to therapy, and the potential value of indirect comparisons. We suggest that cycling of biological agents, until remission is achieved or until the most effective agent for that individual patient is determined, deserves consideration in the current stage of knowledge.
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spelling Applying science in practice: the optimization of biological therapy in rheumatoid arthritisArtrite ReumatóideTerapêutica BiológicaMost authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review explores the application of published evidence to practice, discussing the goals of treatment, the (in) ability to predict individual responses to therapy, and the potential value of indirect comparisons. We suggest that cycling of biological agents, until remission is achieved or until the most effective agent for that individual patient is determined, deserves consideration in the current stage of knowledge.BioMed CentralRIHUCRamiro, SMachado, PSingh, JALandewé, RBPereira da Silva, JA2010-12-10T16:37:31Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/872engArthritis Res Ther. 2010 Nov 4;12(6):220.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:22:03Zoai:rihuc.huc.min-saude.pt:10400.4/872Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:24.747517Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
title Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
spellingShingle Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
Ramiro, S
Artrite Reumatóide
Terapêutica Biológica
title_short Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
title_full Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
title_fullStr Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
title_full_unstemmed Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
title_sort Applying science in practice: the optimization of biological therapy in rheumatoid arthritis
author Ramiro, S
author_facet Ramiro, S
Machado, P
Singh, JA
Landewé, RB
Pereira da Silva, JA
author_role author
author2 Machado, P
Singh, JA
Landewé, RB
Pereira da Silva, JA
author2_role author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Ramiro, S
Machado, P
Singh, JA
Landewé, RB
Pereira da Silva, JA
dc.subject.por.fl_str_mv Artrite Reumatóide
Terapêutica Biológica
topic Artrite Reumatóide
Terapêutica Biológica
description Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review explores the application of published evidence to practice, discussing the goals of treatment, the (in) ability to predict individual responses to therapy, and the potential value of indirect comparisons. We suggest that cycling of biological agents, until remission is achieved or until the most effective agent for that individual patient is determined, deserves consideration in the current stage of knowledge.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-10T16:37:31Z
2010
2010-01-01T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/872
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arthritis Res Ther. 2010 Nov 4;12(6):220.
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dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
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