Separation of nadolol racemates by high pH reversed-phase preparative chromatography

Detalhes bibliográficos
Autor(a) principal: Arafah, Rami
Data de Publicação: 2018
Outros Autores: Ribeiro, António E., Rodrigues, Alírio, Pais, Luís S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/19524
Resumo: The separation of nadolol racemates under high pH reversed-phase preparative chromatography is presented for the first time. Three Waters C18 adsorbents (XBridge, Shield and XSelect) are compared for the separation of nadolol racemates using ethanol:water:diethylamine solvent mixtures. Experimental and simulation results are presented to compare the separation performances at preparative scale using both the fixed-bed and the simulated moving bed operations. The Waters XBridge C18 adsorbent and an ethanol:water:diethylamine solvent mixture are selected as a good option for the separation of nadolol racemates. The validated methodology allows the separation of a multicomponent nadolol feed mixture composed by four stereoisomers into two pure racemates (two pairs of enantiomers). This work introduces the potential of using an initial achiral separation step in the global strategy for the complete multicomponent separation of the four nadolol stereoisomers.
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spelling Separation of nadolol racemates by high pH reversed-phase preparative chromatographyMulticomponent separationNadololReversed-phase preparative chromatographyThe separation of nadolol racemates under high pH reversed-phase preparative chromatography is presented for the first time. Three Waters C18 adsorbents (XBridge, Shield and XSelect) are compared for the separation of nadolol racemates using ethanol:water:diethylamine solvent mixtures. Experimental and simulation results are presented to compare the separation performances at preparative scale using both the fixed-bed and the simulated moving bed operations. The Waters XBridge C18 adsorbent and an ethanol:water:diethylamine solvent mixture are selected as a good option for the separation of nadolol racemates. The validated methodology allows the separation of a multicomponent nadolol feed mixture composed by four stereoisomers into two pure racemates (two pairs of enantiomers). This work introduces the potential of using an initial achiral separation step in the global strategy for the complete multicomponent separation of the four nadolol stereoisomers.This work is a result of: Project “AIProcMat@N2020 - Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020”, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); Associate Laboratory LSRE-LCM - UID/EQU/50020/2019 - funded by national funds through FCT/MCTES (PIDDAC). Rami S. Arafah is supported by a PhD Grant of Fundação para a Ciência e a Tecnologia (SFRH/BD/137966/2018).Biblioteca Digital do IPBArafah, RamiRibeiro, António E.Rodrigues, AlírioPais, Luís S.2018-01-19T10:00:00Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/19524engArafah, Rami S.; Ribeiro, António E.; Rodrigues, Alírio E.; Pais, Luís S. (2020). Separation of nadolol racemates by high pH reversed-phase preparative chromatography. Separation and Purification Technology. ISSN 1383-5866. 233, p. 1-131383-586610.1016/j.seppur.2019.116018info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:46:05Zoai:bibliotecadigital.ipb.pt:10198/19524Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:10:57.584724Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Separation of nadolol racemates by high pH reversed-phase preparative chromatography
title Separation of nadolol racemates by high pH reversed-phase preparative chromatography
spellingShingle Separation of nadolol racemates by high pH reversed-phase preparative chromatography
Arafah, Rami
Multicomponent separation
Nadolol
Reversed-phase preparative chromatography
title_short Separation of nadolol racemates by high pH reversed-phase preparative chromatography
title_full Separation of nadolol racemates by high pH reversed-phase preparative chromatography
title_fullStr Separation of nadolol racemates by high pH reversed-phase preparative chromatography
title_full_unstemmed Separation of nadolol racemates by high pH reversed-phase preparative chromatography
title_sort Separation of nadolol racemates by high pH reversed-phase preparative chromatography
author Arafah, Rami
author_facet Arafah, Rami
Ribeiro, António E.
Rodrigues, Alírio
Pais, Luís S.
author_role author
author2 Ribeiro, António E.
Rodrigues, Alírio
Pais, Luís S.
author2_role author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Arafah, Rami
Ribeiro, António E.
Rodrigues, Alírio
Pais, Luís S.
dc.subject.por.fl_str_mv Multicomponent separation
Nadolol
Reversed-phase preparative chromatography
topic Multicomponent separation
Nadolol
Reversed-phase preparative chromatography
description The separation of nadolol racemates under high pH reversed-phase preparative chromatography is presented for the first time. Three Waters C18 adsorbents (XBridge, Shield and XSelect) are compared for the separation of nadolol racemates using ethanol:water:diethylamine solvent mixtures. Experimental and simulation results are presented to compare the separation performances at preparative scale using both the fixed-bed and the simulated moving bed operations. The Waters XBridge C18 adsorbent and an ethanol:water:diethylamine solvent mixture are selected as a good option for the separation of nadolol racemates. The validated methodology allows the separation of a multicomponent nadolol feed mixture composed by four stereoisomers into two pure racemates (two pairs of enantiomers). This work introduces the potential of using an initial achiral separation step in the global strategy for the complete multicomponent separation of the four nadolol stereoisomers.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-19T10:00:00Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/19524
url http://hdl.handle.net/10198/19524
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arafah, Rami S.; Ribeiro, António E.; Rodrigues, Alírio E.; Pais, Luís S. (2020). Separation of nadolol racemates by high pH reversed-phase preparative chromatography. Separation and Purification Technology. ISSN 1383-5866. 233, p. 1-13
1383-5866
10.1016/j.seppur.2019.116018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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