Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/4840 https://doi.org/10.1016/S0162-0134(99)00232-9 |
Resumo: | The solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by 1H, 71Ga and 31P NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)3- complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C3 axis. The 1H spectrum shows that the triazamacrocyclic chelate ring is very rigid, with all the ring protons non-equivalent. The complex is stable in aqueous solution in a wide pH range. Its high thermodynamic stability agrees well with previous results from biodistribution and [gamma] imaging studies in Wistar rats with 67Ga3+ chelates of triaza macrocyclic ligands, which showed that the neutral chelates 67Ga(NOTA) (where NOTA is 1,4,7-triazacyclononane-1,4,7-triacetate) and 67Ga(NOTPME) (where NOTPME is 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate monoethylester)) have similar in vivo behaviour, with high stability and rapid renal excretion, but the high negatively charged 67Ga(NOTP)3- has a considerably slower kidney uptake and elimination. |
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Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imagingGalliumTriazamacrocyclePhosphonateStructureBiodistributionThe solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by 1H, 71Ga and 31P NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)3- complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C3 axis. The 1H spectrum shows that the triazamacrocyclic chelate ring is very rigid, with all the ring protons non-equivalent. The complex is stable in aqueous solution in a wide pH range. Its high thermodynamic stability agrees well with previous results from biodistribution and [gamma] imaging studies in Wistar rats with 67Ga3+ chelates of triaza macrocyclic ligands, which showed that the neutral chelates 67Ga(NOTA) (where NOTA is 1,4,7-triazacyclononane-1,4,7-triacetate) and 67Ga(NOTPME) (where NOTPME is 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate monoethylester)) have similar in vivo behaviour, with high stability and rapid renal excretion, but the high negatively charged 67Ga(NOTP)3- has a considerably slower kidney uptake and elimination.http://www.sciencedirect.com/science/article/B6TGG-40X8D8M-26/1/b0839261f5ddd424e05a2da9204295a22000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4840http://hdl.handle.net/10316/4840https://doi.org/10.1016/S0162-0134(99)00232-9engJournal of Inorganic Biochemistry. 79:1-4 (2000) 359-363Prata, M. I. M.Santos, A. C.Geraldes, C. F. G. C.Lima, J. J. P. deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T03:25:50Zoai:estudogeral.uc.pt:10316/4840Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:34.657352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
title |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
spellingShingle |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging Prata, M. I. M. Gallium Triazamacrocycle Phosphonate Structure Biodistribution |
title_short |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
title_full |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
title_fullStr |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
title_full_unstemmed |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
title_sort |
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging |
author |
Prata, M. I. M. |
author_facet |
Prata, M. I. M. Santos, A. C. Geraldes, C. F. G. C. Lima, J. J. P. de |
author_role |
author |
author2 |
Santos, A. C. Geraldes, C. F. G. C. Lima, J. J. P. de |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Prata, M. I. M. Santos, A. C. Geraldes, C. F. G. C. Lima, J. J. P. de |
dc.subject.por.fl_str_mv |
Gallium Triazamacrocycle Phosphonate Structure Biodistribution |
topic |
Gallium Triazamacrocycle Phosphonate Structure Biodistribution |
description |
The solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by 1H, 71Ga and 31P NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)3- complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C3 axis. The 1H spectrum shows that the triazamacrocyclic chelate ring is very rigid, with all the ring protons non-equivalent. The complex is stable in aqueous solution in a wide pH range. Its high thermodynamic stability agrees well with previous results from biodistribution and [gamma] imaging studies in Wistar rats with 67Ga3+ chelates of triaza macrocyclic ligands, which showed that the neutral chelates 67Ga(NOTA) (where NOTA is 1,4,7-triazacyclononane-1,4,7-triacetate) and 67Ga(NOTPME) (where NOTPME is 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate monoethylester)) have similar in vivo behaviour, with high stability and rapid renal excretion, but the high negatively charged 67Ga(NOTP)3- has a considerably slower kidney uptake and elimination. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/4840 http://hdl.handle.net/10316/4840 https://doi.org/10.1016/S0162-0134(99)00232-9 |
url |
http://hdl.handle.net/10316/4840 https://doi.org/10.1016/S0162-0134(99)00232-9 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Inorganic Biochemistry. 79:1-4 (2000) 359-363 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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