Exosomes genetic cargo in lung cancer: a truly Pandora's box
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2160 |
Resumo: | Lung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue biopsy due to improvements in analytical techniques for circulating tumor cells (CTCs), cell free DNA and exosomes. Among all, exosomes have raised as one of the most promising tools to understand the tumor due to their stability in the blood and their similarity to the cells of origin. In the last years, different alterations have been described inside the exosomes derived from non-small cell lung cancer (NSCLC) cells mirroring the processes inside these tumoral cells, such as EGFR mutation, translocations or microRNA (miRNA) deregulation. All these studies have opened the window to a new world of possibilities in the study of tumor biomarkers. |
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7160 |
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Exosomes genetic cargo in lung cancer: a truly Pandora's boxNon-small cell lung cancer (NSCLC)exosomesliquid biopsyncRNAsLung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue biopsy due to improvements in analytical techniques for circulating tumor cells (CTCs), cell free DNA and exosomes. Among all, exosomes have raised as one of the most promising tools to understand the tumor due to their stability in the blood and their similarity to the cells of origin. In the last years, different alterations have been described inside the exosomes derived from non-small cell lung cancer (NSCLC) cells mirroring the processes inside these tumoral cells, such as EGFR mutation, translocations or microRNA (miRNA) deregulation. All these studies have opened the window to a new world of possibilities in the study of tumor biomarkers.Pioneer Bioscience Publishing CompanyRepositório Científico do Centro Hospitalar Universitário de Santo AntónioReclusa, P.Sirera, R.Araujo, A.Giallombardo, M.Valentino, A.Sorber, L.Bazo, I.Pauwels, P.Rolfo, C.2017-07-24T15:01:22Z2016-102016-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2160engTransl Lung Cancer Res. 2016 Oct;5(5):483-4912226-447710.21037/tlcr.2016.10.06info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:59:20Zoai:repositorio.chporto.pt:10400.16/2160Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:24.233442Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
title |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
spellingShingle |
Exosomes genetic cargo in lung cancer: a truly Pandora's box Reclusa, P. Non-small cell lung cancer (NSCLC) exosomes liquid biopsy ncRNAs |
title_short |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
title_full |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
title_fullStr |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
title_full_unstemmed |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
title_sort |
Exosomes genetic cargo in lung cancer: a truly Pandora's box |
author |
Reclusa, P. |
author_facet |
Reclusa, P. Sirera, R. Araujo, A. Giallombardo, M. Valentino, A. Sorber, L. Bazo, I. Pauwels, P. Rolfo, C. |
author_role |
author |
author2 |
Sirera, R. Araujo, A. Giallombardo, M. Valentino, A. Sorber, L. Bazo, I. Pauwels, P. Rolfo, C. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Reclusa, P. Sirera, R. Araujo, A. Giallombardo, M. Valentino, A. Sorber, L. Bazo, I. Pauwels, P. Rolfo, C. |
dc.subject.por.fl_str_mv |
Non-small cell lung cancer (NSCLC) exosomes liquid biopsy ncRNAs |
topic |
Non-small cell lung cancer (NSCLC) exosomes liquid biopsy ncRNAs |
description |
Lung cancer is a highly lethal disease. Targeted therapies have been developed in last years, however survival rates are not improving due to the delay in the diagnosis, making biomarkers one of the most interesting fields of study in cancer. Liquid biopsy has raised as an alternative to tissue biopsy due to improvements in analytical techniques for circulating tumor cells (CTCs), cell free DNA and exosomes. Among all, exosomes have raised as one of the most promising tools to understand the tumor due to their stability in the blood and their similarity to the cells of origin. In the last years, different alterations have been described inside the exosomes derived from non-small cell lung cancer (NSCLC) cells mirroring the processes inside these tumoral cells, such as EGFR mutation, translocations or microRNA (miRNA) deregulation. All these studies have opened the window to a new world of possibilities in the study of tumor biomarkers. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10 2016-10-01T00:00:00Z 2017-07-24T15:01:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2160 |
url |
http://hdl.handle.net/10400.16/2160 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Transl Lung Cancer Res. 2016 Oct;5(5):483-491 2226-4477 10.21037/tlcr.2016.10.06 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Pioneer Bioscience Publishing Company |
publisher.none.fl_str_mv |
Pioneer Bioscience Publishing Company |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133645610418176 |