Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review

Detalhes bibliográficos
Autor(a) principal: Maria Joao Gouveia
Data de Publicação: 2013
Outros Autores: Paul J Brindley, Lucio Lara Santos, Jose Manuel C Correia da Costa, Paula Gomes, Nuno Vale
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/82022
Resumo: Mass spectrometric approaches have been fundamental to the identification of metabolites associated with steroid hormones, yet this topic has not been reviewed in depth in recent years. To this end, and given the increasing relevance of liquid chromatography-mass spectrometry (LC-MS) studies on steroid hormones and their metabolites, the present review addresses this subject. This review provides a timely summary of the use of various mass spectrometry-based analytical techniques during the evaluation of steroidal biomarkers in a range of human disease settings. The sensitivity and specificity of these technologies are clearly providing valuable new insights into breast cancer and cardiovascular disease. We aim to contribute to an enhanced understanding of steroid metabolism and how it can be profiled by LC-MS techniques. Crown Copyright
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spelling Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A reviewMedicina básicaBasic medicineMass spectrometric approaches have been fundamental to the identification of metabolites associated with steroid hormones, yet this topic has not been reviewed in depth in recent years. To this end, and given the increasing relevance of liquid chromatography-mass spectrometry (LC-MS) studies on steroid hormones and their metabolites, the present review addresses this subject. This review provides a timely summary of the use of various mass spectrometry-based analytical techniques during the evaluation of steroidal biomarkers in a range of human disease settings. The sensitivity and specificity of these technologies are clearly providing valuable new insights into breast cancer and cardiovascular disease. We aim to contribute to an enhanced understanding of steroid metabolism and how it can be profiled by LC-MS techniques. Crown Copyright20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/82022eng0026-049510.1016/j.metabol.2013.04.003Maria Joao GouveiaPaul J BrindleyLucio Lara SantosJose Manuel C Correia da CostaPaula GomesNuno Valeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:11:14Zoai:repositorio-aberto.up.pt:10216/82022Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:56:38.779238Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
title Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
spellingShingle Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
Maria Joao Gouveia
Medicina básica
Basic medicine
title_short Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
title_full Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
title_fullStr Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
title_full_unstemmed Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
title_sort Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review
author Maria Joao Gouveia
author_facet Maria Joao Gouveia
Paul J Brindley
Lucio Lara Santos
Jose Manuel C Correia da Costa
Paula Gomes
Nuno Vale
author_role author
author2 Paul J Brindley
Lucio Lara Santos
Jose Manuel C Correia da Costa
Paula Gomes
Nuno Vale
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maria Joao Gouveia
Paul J Brindley
Lucio Lara Santos
Jose Manuel C Correia da Costa
Paula Gomes
Nuno Vale
dc.subject.por.fl_str_mv Medicina básica
Basic medicine
topic Medicina básica
Basic medicine
description Mass spectrometric approaches have been fundamental to the identification of metabolites associated with steroid hormones, yet this topic has not been reviewed in depth in recent years. To this end, and given the increasing relevance of liquid chromatography-mass spectrometry (LC-MS) studies on steroid hormones and their metabolites, the present review addresses this subject. This review provides a timely summary of the use of various mass spectrometry-based analytical techniques during the evaluation of steroidal biomarkers in a range of human disease settings. The sensitivity and specificity of these technologies are clearly providing valuable new insights into breast cancer and cardiovascular disease. We aim to contribute to an enhanced understanding of steroid metabolism and how it can be profiled by LC-MS techniques. Crown Copyright
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/82022
url https://repositorio-aberto.up.pt/handle/10216/82022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0026-0495
10.1016/j.metabol.2013.04.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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