Non-AIDS-Related Comorbidities in People Living with HIV-1 Aged 50 Years and Older: The AGING POSITIVE Study

• Autor(a) principal: Serrão, R
• Data de Publicação: 2019
• Outros Autores: Piñero, C, Velez, J, Coutinho, D, Maltez, F, Lino, S, Sarmento E Castro, R, Tavares, AP, Pacheco, P, Lopes, MJ, Mansinho, K, Miranda, AC, Neves, I, Correia de Abreu, R, Almeida, J, Pássaro, L
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.17/3484
• topic: Acquired Immunodeficiency Syndrome; Aged; Anti-Retroviral Agents; Antihypertensive Agents; Anxiety Disorders; Comorbidity; Cross-Sectional Studies; Depression; Diabetes Mellitus; Female; HIV Infections; HIV-1; Humans; Hypertension; Hypolipidemic Agents; Male; Middle Aged; Portugal; Prevalence; Socioeconomic Factors; HCC INF

Objective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. Results: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). Conclusions: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population.