Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48675 |
Resumo: | © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhance phagocytosis by neutrophils. Apcs-/- mice are defective in vivo in terms of recruitment of neutrophils and phagocytosis in the lungs. Opsonic activity of SAP is dependent on the classical pathway of complement activation. In immunosuppressed mice, SAP administration protects hosts against A. fumigatus infection and death. In the context of a study of hematopoietic stem-cell transplantation, genetic variation in the human APCS gene is associated with susceptibility to invasive pulmonary aspergillosis. Thus, SAP is a fluid phase pattern recognition molecule essential for resistance against A. fumigatus.The contribution of the European Commission (ERC project PHII-669415; FP7 project 281608 TIMER; ESA/ITN, H2020-MSCA-ITN-2015-676129), Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) (project FIRB RBAP11H2R9), Associazione Italiana Ricerca sul Cancro (AIRC IG-19014 and IG-21714, AIRC 5 × 1000 −9962 and −21147), the Italian Ministry of Health, the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023), the Fundação para a Ciência e Tecnologia (FCT) (UIDB/50026/2020, UIDP/50026/2020, PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, CEECIND/04058/2018 and CEECIND/03628/2017), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 847507 and the “la Caixa” Foundation (ID 100010434) and FCT under the agreement LCF/PR/HR17/52190003 is gratefully acknowledged.Springer NatureRepositório da Universidade de LisboaDoni, AndreaParente, RaffaellaLaface, IlariaMagrini, ElenaCunha, CristinaColombo, Federico SimoneLacerda, JoãoCampos, AntónioMapelli, Sarah N.Petroni, FrancescaPorte, RémiSchorn, TiloInforzato, AntonioMercier, ToineLagrou, KatrienMaertens, JohanLambris, John D.Bottazzi, BarbaraGarlanda, CeciliaBotto, MarinaCarvalho, AgostinhoMantovani, Alberto2021-06-21T16:11:37Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48675engNat Commun. 2021 Jun 18;12(1):373910.1038/s41467-021-24021-y2041-1723info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:01Zoai:repositorio.ul.pt:10451/48675Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:26.147691Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
title |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
spellingShingle |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus Doni, Andrea |
title_short |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
title_full |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
title_fullStr |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
title_full_unstemmed |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
title_sort |
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus |
author |
Doni, Andrea |
author_facet |
Doni, Andrea Parente, Raffaella Laface, Ilaria Magrini, Elena Cunha, Cristina Colombo, Federico Simone Lacerda, João Campos, António Mapelli, Sarah N. Petroni, Francesca Porte, Rémi Schorn, Tilo Inforzato, Antonio Mercier, Toine Lagrou, Katrien Maertens, Johan Lambris, John D. Bottazzi, Barbara Garlanda, Cecilia Botto, Marina Carvalho, Agostinho Mantovani, Alberto |
author_role |
author |
author2 |
Parente, Raffaella Laface, Ilaria Magrini, Elena Cunha, Cristina Colombo, Federico Simone Lacerda, João Campos, António Mapelli, Sarah N. Petroni, Francesca Porte, Rémi Schorn, Tilo Inforzato, Antonio Mercier, Toine Lagrou, Katrien Maertens, Johan Lambris, John D. Bottazzi, Barbara Garlanda, Cecilia Botto, Marina Carvalho, Agostinho Mantovani, Alberto |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Doni, Andrea Parente, Raffaella Laface, Ilaria Magrini, Elena Cunha, Cristina Colombo, Federico Simone Lacerda, João Campos, António Mapelli, Sarah N. Petroni, Francesca Porte, Rémi Schorn, Tilo Inforzato, Antonio Mercier, Toine Lagrou, Katrien Maertens, Johan Lambris, John D. Bottazzi, Barbara Garlanda, Cecilia Botto, Marina Carvalho, Agostinho Mantovani, Alberto |
description |
© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-21T16:11:37Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48675 |
url |
http://hdl.handle.net/10451/48675 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nat Commun. 2021 Jun 18;12(1):3739 10.1038/s41467-021-24021-y 2041-1723 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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