An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells

Detalhes bibliográficos
Autor(a) principal: Dias, Cristina J.
Data de Publicação: 2020
Outros Autores: Sardo, Inês, Moura, Nuno M. M., Felgueiras, Juliana, Neves, M. Graça P. M. S., Fardilha, Margarida, Faustino, M. Amparo F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/29393
Resumo: An efficient access to porphyrin derivatives bearing uracil-alditol moieties at the beta-pyrrolic position was developed. The synthetic strategy involved a hetero Diels-Alder reaction between uracil-alditol based ortho-quinodimethanes using 2-vinyl-5,10,15,20-tetraphenylporphyrin as the scaffold. The preliminary evaluation of their photodynamic effectiveness in prostate cancer cells suggests that the adducts 4-Xyl and 4-Gal are promising photodynamic agents.
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spelling An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cellsPorphyrin derivativesUracil-alditolsPhotodynamic therapyProstate cancerAn efficient access to porphyrin derivatives bearing uracil-alditol moieties at the beta-pyrrolic position was developed. The synthetic strategy involved a hetero Diels-Alder reaction between uracil-alditol based ortho-quinodimethanes using 2-vinyl-5,10,15,20-tetraphenylporphyrin as the scaffold. The preliminary evaluation of their photodynamic effectiveness in prostate cancer cells suggests that the adducts 4-Xyl and 4-Gal are promising photodynamic agents.Elsevier2020-022020-02-01T00:00:00Z2022-02-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29393eng0143-720810.1016/j.dyepig.2019.107996Dias, Cristina J.Sardo, InêsMoura, Nuno M. M.Felgueiras, JulianaNeves, M. Graça P. M. S.Fardilha, MargaridaFaustino, M. Amparo F.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-06T04:27:18Zoai:ria.ua.pt:10773/29393Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-06T04:27:18Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
title An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
spellingShingle An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
Dias, Cristina J.
Porphyrin derivatives
Uracil-alditols
Photodynamic therapy
Prostate cancer
title_short An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
title_full An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
title_fullStr An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
title_full_unstemmed An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
title_sort An efficient synthetic access to new uracil-alditols bearing a porphyrin unit and biological assessment in prostate cancer cells
author Dias, Cristina J.
author_facet Dias, Cristina J.
Sardo, Inês
Moura, Nuno M. M.
Felgueiras, Juliana
Neves, M. Graça P. M. S.
Fardilha, Margarida
Faustino, M. Amparo F.
author_role author
author2 Sardo, Inês
Moura, Nuno M. M.
Felgueiras, Juliana
Neves, M. Graça P. M. S.
Fardilha, Margarida
Faustino, M. Amparo F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dias, Cristina J.
Sardo, Inês
Moura, Nuno M. M.
Felgueiras, Juliana
Neves, M. Graça P. M. S.
Fardilha, Margarida
Faustino, M. Amparo F.
dc.subject.por.fl_str_mv Porphyrin derivatives
Uracil-alditols
Photodynamic therapy
Prostate cancer
topic Porphyrin derivatives
Uracil-alditols
Photodynamic therapy
Prostate cancer
description An efficient access to porphyrin derivatives bearing uracil-alditol moieties at the beta-pyrrolic position was developed. The synthetic strategy involved a hetero Diels-Alder reaction between uracil-alditol based ortho-quinodimethanes using 2-vinyl-5,10,15,20-tetraphenylporphyrin as the scaffold. The preliminary evaluation of their photodynamic effectiveness in prostate cancer cells suggests that the adducts 4-Xyl and 4-Gal are promising photodynamic agents.
publishDate 2020
dc.date.none.fl_str_mv 2020-02
2020-02-01T00:00:00Z
2022-02-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/29393
url http://hdl.handle.net/10773/29393
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0143-7208
10.1016/j.dyepig.2019.107996
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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