Gut Dysbiosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/153048 |
Resumo: | Funding Information: This research was funded by FWO and F.R.S.-FNRS under the Excellence of Science Program (EOS), MODEL-IDI Ref. number 30826052, and CD-INFLADIS Ref. number 40007512. A.C.P. is funded by FCT SFRH/BD/14611/2019. I.S.L was funded by FCT SFRH/BD/114552/2016 and is funded by MODEL-IDI Ref. number 30826052; A.C.M. was funded by FCT SFRH/BD/104599/2014; R.G. was funded by FCT IF 01495/2015. Publisher Copyright: © 2023 by the authors. |
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Gut DysbiosisA Target for Protective Interventions against Parkinson’s Diseasegut microbiomeinflammationironneuroinflammationParkinson’s diseaseMicrobiologyMicrobiology (medical)VirologyFunding Information: This research was funded by FWO and F.R.S.-FNRS under the Excellence of Science Program (EOS), MODEL-IDI Ref. number 30826052, and CD-INFLADIS Ref. number 40007512. A.C.P. is funded by FCT SFRH/BD/14611/2019. I.S.L was funded by FCT SFRH/BD/114552/2016 and is funded by MODEL-IDI Ref. number 30826052; A.C.M. was funded by FCT SFRH/BD/104599/2014; R.G. was funded by FCT IF 01495/2015. Publisher Copyright: © 2023 by the authors.Sub-chronic inflammation, caused by age-related dysbiosis, primes the brain to neuroinflammation and neurodegenerative diseases. Evidence revealed that Parkinson’s disease (PD) might originate in the gut, demonstrating gastro-intestinal disturbances, as reported by PD patients long before developing motor symptoms. In this study, we conducted comparative analyses in relatively young and old mice maintained in conventional or gnotobiotic conditions. We aimed to confirm that the effects induced by age-related dysbiosis, rather than aging itself, sensitize to PD onset. This hypothesis was confirmed in germ-free (GF) mice, which proved resistant to the pharmacological induction of PD, regardless of their age. Contrary to conventional animals, old GF mice did not develop an inflammatory phenotype or an accumulation of iron in the brain, two catalysts sensitizing to disease onset. The resistance of GF mice to PD is reverted when colonized with stool collected from conventional old animals, but not if receiving bacterial content from young mice. Hence, changes in gut microbiota composition are a risk factor for PD development and can be targeted preventively by iron chelators, shown to protect the brain from pro-inflammatory intestinal priming that sensitizes to neuroinflammation and the development of severe PD.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNLima, Illyane S.Pêgo, Ana C.Martins, Ana C.Prada, Ana R.Barros, João TomásMartins, GracelinoGozzelino, Raffaella2023-05-22T22:18:12Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/153048eng2076-2607PURE: 60683487https://doi.org/10.3390/microorganisms11040880info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-17T01:31:52ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
Gut Dysbiosis A Target for Protective Interventions against Parkinson’s Disease |
| title |
Gut Dysbiosis |
| spellingShingle |
Gut Dysbiosis Lima, Illyane S. gut microbiome inflammation iron neuroinflammation Parkinson’s disease Microbiology Microbiology (medical) Virology |
| title_short |
Gut Dysbiosis |
| title_full |
Gut Dysbiosis |
| title_fullStr |
Gut Dysbiosis |
| title_full_unstemmed |
Gut Dysbiosis |
| title_sort |
Gut Dysbiosis |
| author |
Lima, Illyane S. |
| author_facet |
Lima, Illyane S. Pêgo, Ana C. Martins, Ana C. Prada, Ana R. Barros, João Tomás Martins, Gracelino Gozzelino, Raffaella |
| author_role |
author |
| author2 |
Pêgo, Ana C. Martins, Ana C. Prada, Ana R. Barros, João Tomás Martins, Gracelino Gozzelino, Raffaella |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Lima, Illyane S. Pêgo, Ana C. Martins, Ana C. Prada, Ana R. Barros, João Tomás Martins, Gracelino Gozzelino, Raffaella |
| dc.subject.por.fl_str_mv |
gut microbiome inflammation iron neuroinflammation Parkinson’s disease Microbiology Microbiology (medical) Virology |
| topic |
gut microbiome inflammation iron neuroinflammation Parkinson’s disease Microbiology Microbiology (medical) Virology |
| description |
Funding Information: This research was funded by FWO and F.R.S.-FNRS under the Excellence of Science Program (EOS), MODEL-IDI Ref. number 30826052, and CD-INFLADIS Ref. number 40007512. A.C.P. is funded by FCT SFRH/BD/14611/2019. I.S.L was funded by FCT SFRH/BD/114552/2016 and is funded by MODEL-IDI Ref. number 30826052; A.C.M. was funded by FCT SFRH/BD/104599/2014; R.G. was funded by FCT IF 01495/2015. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-05-22T22:18:12Z 2023-04 2023-04-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/153048 |
| url |
http://hdl.handle.net/10362/153048 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2076-2607 PURE: 60683487 https://doi.org/10.3390/microorganisms11040880 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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1777303102204936192 |