Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology

Detalhes bibliográficos
Autor(a) principal: Viveiros, Raquel
Data de Publicação: 2023
Outros Autores: Pinto, José J., Costa, Nuno, Heggie, William, Casimiro, Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154618
Resumo: Funding Information: The Associate Laboratory for Green Chemistry for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES and co-financed by the ERDF under the PT2020 Partnership Agreement ( POCI-01–0145-FEDER – 007265 ). Publisher Copyright: © 2023
id RCAP_c28562e1e436ab304efe17193bf2b714
oai_identifier_str oai:run.unl.pt:10362/154618
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technologyAffinity purificationGenotoxin removalMolecularly imprinted polymerSolid-phase extractionSupercritical carbon dioxideChemical Engineering(all)Condensed Matter PhysicsPhysical and Theoretical ChemistryFunding Information: The Associate Laboratory for Green Chemistry for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES and co-financed by the ERDF under the PT2020 Partnership Agreement ( POCI-01–0145-FEDER – 007265 ). Publisher Copyright: © 2023Polymeric particles with affinity for 4-dimethylaminipyridine (DMAP) were developed by molecular imprinting using supercritical carbon dioxide (scCO2) technology, for cleanup of this potentially genotoxic impurity from crude mixtures of Active Pharmaceutical Ingredients (APIs). DMAP-molecularly imprinted polymer (DMAP-MIP) and the respective control, the non-molecularly imprinted polymer (NIP) were produced by free radical polymerization using methacrylic acid as monomer, ethylene glycol dimethacrylate as crosslinker and AIBN as free-radical initiator in scCO2. The materials were obtained in high yield and were characterized chemically, physically and morphologically. Their extraction efficiency was evaluated by dynamic binding experiments using two solutions: i) a solution containing 104 ppm DMAP solution; ii) model pharmaceutical mixture containing 104 ppm of DMAP and 1018 ppm of Mometasone furoate (API). Particles were able to remove 18.3 µmol DMAP/g polymer from a 104 ppm DMAP solution (i) and 1004.6 µmol DMAP/g API (ii). In addition, high recoveries of both DMAP and API were obtained, above 99%.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNViveiros, RaquelPinto, José J.Costa, NunoHeggie, WilliamCasimiro, Teresa2023-06-29T22:16:58Z2023-032023-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://hdl.handle.net/10362/154618eng0896-8446PURE: 64820451https://doi.org/10.1016/j.supflu.2023.105853info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:05Zoai:run.unl.pt:10362/154618Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:41.951595Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
title Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
spellingShingle Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
Viveiros, Raquel
Affinity purification
Genotoxin removal
Molecularly imprinted polymer
Solid-phase extraction
Supercritical carbon dioxide
Chemical Engineering(all)
Condensed Matter Physics
Physical and Theoretical Chemistry
title_short Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
title_full Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
title_fullStr Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
title_full_unstemmed Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
title_sort Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
author Viveiros, Raquel
author_facet Viveiros, Raquel
Pinto, José J.
Costa, Nuno
Heggie, William
Casimiro, Teresa
author_role author
author2 Pinto, José J.
Costa, Nuno
Heggie, William
Casimiro, Teresa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Viveiros, Raquel
Pinto, José J.
Costa, Nuno
Heggie, William
Casimiro, Teresa
dc.subject.por.fl_str_mv Affinity purification
Genotoxin removal
Molecularly imprinted polymer
Solid-phase extraction
Supercritical carbon dioxide
Chemical Engineering(all)
Condensed Matter Physics
Physical and Theoretical Chemistry
topic Affinity purification
Genotoxin removal
Molecularly imprinted polymer
Solid-phase extraction
Supercritical carbon dioxide
Chemical Engineering(all)
Condensed Matter Physics
Physical and Theoretical Chemistry
description Funding Information: The Associate Laboratory for Green Chemistry for Green Chemistry - Clean Technologies and Processes - LAQV is financed by national funds from FCT/MCTES and co-financed by the ERDF under the PT2020 Partnership Agreement ( POCI-01–0145-FEDER – 007265 ). Publisher Copyright: © 2023
publishDate 2023
dc.date.none.fl_str_mv 2023-06-29T22:16:58Z
2023-03
2023-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154618
url http://hdl.handle.net/10362/154618
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0896-8446
PURE: 64820451
https://doi.org/10.1016/j.supflu.2023.105853
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138143692128256

Registros relacionados