Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.

Detalhes bibliográficos
Autor(a) principal: Barbosa, L
Data de Publicação: 2000
Outros Autores: Leal, I, Timóteo, A T, Matias, T
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798
Resumo: Although megaloblastic anemias are generally regarded as chronic conditions of insidious appearance, a megaloblastic state can arise over the course of only a few days due to acute folate or vitamin B12 deficiency. One of the most common causes, though seldom reported, is the nitrous oxide (N02) action in tissue. In fact N02, a volatile substance commonly used in anaesthesia, destroys methylcobalamin, leading to the rapid development of a megaloblastic haematopoiesis. This phenomenon may occur in patients without previous vitamin B12 deficit, but is more frequent and severe when there is a pre-existent deficiency state. A case report is described of a patient with femoral fracture who developed acute anemia after surgery and a latent pernicious anemia was revealed upon investigation.
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spelling Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.Anemia megaloblástica aguda por inalação de óxido nitroso em doente com patologia autoimune múltipla.Although megaloblastic anemias are generally regarded as chronic conditions of insidious appearance, a megaloblastic state can arise over the course of only a few days due to acute folate or vitamin B12 deficiency. One of the most common causes, though seldom reported, is the nitrous oxide (N02) action in tissue. In fact N02, a volatile substance commonly used in anaesthesia, destroys methylcobalamin, leading to the rapid development of a megaloblastic haematopoiesis. This phenomenon may occur in patients without previous vitamin B12 deficit, but is more frequent and severe when there is a pre-existent deficiency state. A case report is described of a patient with femoral fracture who developed acute anemia after surgery and a latent pernicious anemia was revealed upon investigation.Although megaloblastic anemias are generally regarded as chronic conditions of insidious appearance, a megaloblastic state can arise over the course of only a few days due to acute folate or vitamin B12 deficiency. One of the most common causes, though seldom reported, is the nitrous oxide (N02) action in tissue. In fact N02, a volatile substance commonly used in anaesthesia, destroys methylcobalamin, leading to the rapid development of a megaloblastic haematopoiesis. This phenomenon may occur in patients without previous vitamin B12 deficit, but is more frequent and severe when there is a pre-existent deficiency state. A case report is described of a patient with femoral fracture who developed acute anemia after surgery and a latent pernicious anemia was revealed upon investigation.Ordem dos Médicos2000-12-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798oai:ojs.www.actamedicaportuguesa.com:article/1798Acta Médica Portuguesa; Vol. 13 No. 5-6 (2000): Setembro-Dezembro; 309-12Acta Médica Portuguesa; Vol. 13 N.º 5-6 (2000): Setembro-Dezembro; 309-121646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798/1375Barbosa, LLeal, ITimóteo, A TMatias, Tinfo:eu-repo/semantics/openAccess2022-12-20T10:59:07Zoai:ojs.www.actamedicaportuguesa.com:article/1798Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:24.212610Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
Anemia megaloblástica aguda por inalação de óxido nitroso em doente com patologia autoimune múltipla.
title Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
spellingShingle Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
Barbosa, L
title_short Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
title_full Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
title_fullStr Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
title_full_unstemmed Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
title_sort Acute megaloblastic anemia caused by inhalation of nitrous oxide in a patient with multiple autoimmune pathology.
author Barbosa, L
author_facet Barbosa, L
Leal, I
Timóteo, A T
Matias, T
author_role author
author2 Leal, I
Timóteo, A T
Matias, T
author2_role author
author
author
dc.contributor.author.fl_str_mv Barbosa, L
Leal, I
Timóteo, A T
Matias, T
description Although megaloblastic anemias are generally regarded as chronic conditions of insidious appearance, a megaloblastic state can arise over the course of only a few days due to acute folate or vitamin B12 deficiency. One of the most common causes, though seldom reported, is the nitrous oxide (N02) action in tissue. In fact N02, a volatile substance commonly used in anaesthesia, destroys methylcobalamin, leading to the rapid development of a megaloblastic haematopoiesis. This phenomenon may occur in patients without previous vitamin B12 deficit, but is more frequent and severe when there is a pre-existent deficiency state. A case report is described of a patient with femoral fracture who developed acute anemia after surgery and a latent pernicious anemia was revealed upon investigation.
publishDate 2000
dc.date.none.fl_str_mv 2000-12-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798
oai:ojs.www.actamedicaportuguesa.com:article/1798
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/1798
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1798/1375
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 13 No. 5-6 (2000): Setembro-Dezembro; 309-12
Acta Médica Portuguesa; Vol. 13 N.º 5-6 (2000): Setembro-Dezembro; 309-12
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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