Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/134340 |
Resumo: | PD/BD/135264/2017 UID/DTP/04138/2020 UIDP/04138/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 UIDB/50006/2020 UIDB/00100/2020 |
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Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury TreatmentAnti-inflammatory therapyDrug delivery nanosystemsHepatic ischemia and reperfusion injuryInflammationLiposomesLiverQuercetinPharmaceutical SciencePD/BD/135264/2017 UID/DTP/04138/2020 UIDP/04138/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 UIDB/50006/2020 UIDB/00100/2020Ischemia and reperfusion injury (IRI) is a common complication caused by inflammation and oxidative stress resulting from liver surgery. Current therapeutic strategies do not present the desirable efficacy, and severe side effects can occur. To overcome these drawbacks, new therapeutic alternatives are necessary. Drug delivery nanosystems have been explored due to their capacity to improve the therapeutic index of conventional drugs. Within nanocarriers, liposomes are one of the most successful, with several formulations currently in the market. As improved therapeutic outcomes have been demonstrated by using liposomes as drug carriers, this nanosystem was used to deliver quercetin, a flavonoid with anti-inflammatory and antioxidant properties, in hepatic IRI treatment. In the present work, a stable quercetin liposomal formulation was developed and characterized. Additionally, an in vitro model of ischemia and reperfusion was developed with a hypoxia chamber, where the anti-inflammatory potential of liposomal quercetin was evaluated, revealing the downregulation of pro-inflammatory markers. The anti-inflammatory effect of quercetin liposomes was also assessed in vivo in a rat model of hepatic IRI, in which a decrease in inflammation markers and enhanced recovery were observed. These results demonstrate that quercetin liposomes may provide a significant tool for addressing the current bottlenecks in hepatic IRI treatment.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNFerreira‐silva, MargaridaFaria‐silva, CatarinaCarvalheiro, Manuela C.Simões, SandraMarinho, H. SusanaMarcelino, PauloCampos, Maria CelesteMetselaar, Josbert M.Fernandes, EduardaBaptista, Pedro V.Fernandes, Alexandra R.Corvo, M. Luísa2022-03-11T23:22:11Z2022-01-032022-01-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/134340eng1999-4923PURE: 36262534https://doi.org/10.3390/pharmaceutics14010104info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:12:47Zoai:run.unl.pt:10362/134340Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:04.017126Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| title |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| spellingShingle |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment Ferreira‐silva, Margarida Anti-inflammatory therapy Drug delivery nanosystems Hepatic ischemia and reperfusion injury Inflammation Liposomes Liver Quercetin Pharmaceutical Science |
| title_short |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| title_full |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| title_fullStr |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| title_full_unstemmed |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| title_sort |
Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment |
| author |
Ferreira‐silva, Margarida |
| author_facet |
Ferreira‐silva, Margarida Faria‐silva, Catarina Carvalheiro, Manuela C. Simões, Sandra Marinho, H. Susana Marcelino, Paulo Campos, Maria Celeste Metselaar, Josbert M. Fernandes, Eduarda Baptista, Pedro V. Fernandes, Alexandra R. Corvo, M. Luísa |
| author_role |
author |
| author2 |
Faria‐silva, Catarina Carvalheiro, Manuela C. Simões, Sandra Marinho, H. Susana Marcelino, Paulo Campos, Maria Celeste Metselaar, Josbert M. Fernandes, Eduarda Baptista, Pedro V. Fernandes, Alexandra R. Corvo, M. Luísa |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit RUN |
| dc.contributor.author.fl_str_mv |
Ferreira‐silva, Margarida Faria‐silva, Catarina Carvalheiro, Manuela C. Simões, Sandra Marinho, H. Susana Marcelino, Paulo Campos, Maria Celeste Metselaar, Josbert M. Fernandes, Eduarda Baptista, Pedro V. Fernandes, Alexandra R. Corvo, M. Luísa |
| dc.subject.por.fl_str_mv |
Anti-inflammatory therapy Drug delivery nanosystems Hepatic ischemia and reperfusion injury Inflammation Liposomes Liver Quercetin Pharmaceutical Science |
| topic |
Anti-inflammatory therapy Drug delivery nanosystems Hepatic ischemia and reperfusion injury Inflammation Liposomes Liver Quercetin Pharmaceutical Science |
| description |
PD/BD/135264/2017 UID/DTP/04138/2020 UIDP/04138/2020 UIDP/04378/2020 UIDB/04378/2020 LA/P/0140/2020 UIDB/50006/2020 UIDB/00100/2020 |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03-11T23:22:11Z 2022-01-03 2022-01-03T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/134340 |
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http://hdl.handle.net/10362/134340 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1999-4923 PURE: 36262534 https://doi.org/10.3390/pharmaceutics14010104 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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