Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model

Detalhes bibliográficos
Autor(a) principal: Miranda, Alice Augusta Macedo
Data de Publicação: 2018
Outros Autores: Roque, Susana, Pêgo, José M., Correia-Pinto, Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/57897
Resumo: Laparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes.
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spelling Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat modelAnimalsCarbon DioxideCytokinesFemaleInflammationNeurodevelopmental DisordersPneumoperitoneum, ArtificialPregnancyRats, Sprague-DawleyStress, PhysiologicalLaparoscopyCarbon-dioxide pneumoperitoneumNeurodevelopmentCytokineInterleukinCiências Médicas::Medicina BásicaScience & TechnologyLaparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes.FEDER, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the project POCI-01-0145-FEDER-007038; and by the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). A Miranda and S. Roque were supported by FCT grants (SFRH/BD/52059/2012) and (SFRH/BPD/72710/2010), respectively. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to thank Karl Storz GmbH for equipment and technical supportinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMiranda, Alice Augusta MacedoRoque, SusanaPêgo, José M.Correia-Pinto, Jorge2018-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/57897engMiranda, A., Roque, S., Pêgo, J. M., & Correia-Pinto, J. (2018). Neurodevelopment impact of CO 2-pneumoperitoneum in neonates: experimental study in a rat model. Journal of Surgical Research, 221, 293-3030022-48041095-867310.1016/j.jss.2017.09.01429229141https://www.sciencedirect.com/science/article/pii/S002248041730611Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-30T01:31:34Zoai:repositorium.sdum.uminho.pt:1822/57897Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:50:37.546890Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
title Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
spellingShingle Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
Miranda, Alice Augusta Macedo
Animals
Carbon Dioxide
Cytokines
Female
Inflammation
Neurodevelopmental Disorders
Pneumoperitoneum, Artificial
Pregnancy
Rats, Sprague-Dawley
Stress, Physiological
Laparoscopy
Carbon-dioxide pneumoperitoneum
Neurodevelopment
Cytokine
Interleukin
Ciências Médicas::Medicina Básica
Science & Technology
title_short Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
title_full Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
title_fullStr Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
title_full_unstemmed Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
title_sort Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model
author Miranda, Alice Augusta Macedo
author_facet Miranda, Alice Augusta Macedo
Roque, Susana
Pêgo, José M.
Correia-Pinto, Jorge
author_role author
author2 Roque, Susana
Pêgo, José M.
Correia-Pinto, Jorge
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Miranda, Alice Augusta Macedo
Roque, Susana
Pêgo, José M.
Correia-Pinto, Jorge
dc.subject.por.fl_str_mv Animals
Carbon Dioxide
Cytokines
Female
Inflammation
Neurodevelopmental Disorders
Pneumoperitoneum, Artificial
Pregnancy
Rats, Sprague-Dawley
Stress, Physiological
Laparoscopy
Carbon-dioxide pneumoperitoneum
Neurodevelopment
Cytokine
Interleukin
Ciências Médicas::Medicina Básica
Science & Technology
topic Animals
Carbon Dioxide
Cytokines
Female
Inflammation
Neurodevelopmental Disorders
Pneumoperitoneum, Artificial
Pregnancy
Rats, Sprague-Dawley
Stress, Physiological
Laparoscopy
Carbon-dioxide pneumoperitoneum
Neurodevelopment
Cytokine
Interleukin
Ciências Médicas::Medicina Básica
Science & Technology
description Laparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/57897
url https://hdl.handle.net/1822/57897
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Miranda, A., Roque, S., Pêgo, J. M., & Correia-Pinto, J. (2018). Neurodevelopment impact of CO 2-pneumoperitoneum in neonates: experimental study in a rat model. Journal of Surgical Research, 221, 293-303
0022-4804
1095-8673
10.1016/j.jss.2017.09.014
29229141
https://www.sciencedirect.com/science/article/pii/S002248041730611X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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