Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers

Detalhes bibliográficos
Autor(a) principal: Sarmento, Bruno
Data de Publicação: 2006
Outros Autores: Martins, Susana, Ribeiro, António, Veiga, Francisco, Neufeld, Ronald, Ferreira, Domingos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/7958
https://doi.org/10.1007/s10989-005-9010-3
Resumo: The overall objective of our research is to produce polyanion/chitosan nanoparticulate oral delivery systems for insulin. Specific objectives of the present study were to study dextran sulfate or alginate complexation with chitosan on mean particle size, insulin association efficiency, loading capacity and release profile. Nanoparticles were formed by ionotropic complexation and coacervation between polyanions (dextran sulfate and alginate) and chitosan. Diameter was evaluated with photon correlation spectroscopy, polymer interaction was confirmed by DSC and FTIR and particle morphology was assessed by SEM and TEM. Mean nanoparticle diameter ranged from 423 to 850 nm, insulin association efficiency from 63 to 94% and loading capacity from 5 to 13%. Dextran sulfate provided highest insulin association efficiency and retention of insulin in gastric simulated conditions. These nanoparticle systems show promise as insulin and potentially other therapeutic polypeptides carriers.
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spelling Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin CarriersThe overall objective of our research is to produce polyanion/chitosan nanoparticulate oral delivery systems for insulin. Specific objectives of the present study were to study dextran sulfate or alginate complexation with chitosan on mean particle size, insulin association efficiency, loading capacity and release profile. Nanoparticles were formed by ionotropic complexation and coacervation between polyanions (dextran sulfate and alginate) and chitosan. Diameter was evaluated with photon correlation spectroscopy, polymer interaction was confirmed by DSC and FTIR and particle morphology was assessed by SEM and TEM. Mean nanoparticle diameter ranged from 423 to 850 nm, insulin association efficiency from 63 to 94% and loading capacity from 5 to 13%. Dextran sulfate provided highest insulin association efficiency and retention of insulin in gastric simulated conditions. These nanoparticle systems show promise as insulin and potentially other therapeutic polypeptides carriers.2006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/7958http://hdl.handle.net/10316/7958https://doi.org/10.1007/s10989-005-9010-3engInternational Journal of Peptide Research and Therapeutics. 12:2 (2006) 131-138Sarmento, BrunoMartins, SusanaRibeiro, AntónioVeiga, FranciscoNeufeld, RonaldFerreira, Domingosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-04T07:58:55Zoai:estudogeral.uc.pt:10316/7958Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:21.713686Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
title Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
spellingShingle Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
Sarmento, Bruno
title_short Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
title_full Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
title_fullStr Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
title_full_unstemmed Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
title_sort Development and Comparison of Different Nanoparticulate Polyelectrolyte Complexes as Insulin Carriers
author Sarmento, Bruno
author_facet Sarmento, Bruno
Martins, Susana
Ribeiro, António
Veiga, Francisco
Neufeld, Ronald
Ferreira, Domingos
author_role author
author2 Martins, Susana
Ribeiro, António
Veiga, Francisco
Neufeld, Ronald
Ferreira, Domingos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Sarmento, Bruno
Martins, Susana
Ribeiro, António
Veiga, Francisco
Neufeld, Ronald
Ferreira, Domingos
description The overall objective of our research is to produce polyanion/chitosan nanoparticulate oral delivery systems for insulin. Specific objectives of the present study were to study dextran sulfate or alginate complexation with chitosan on mean particle size, insulin association efficiency, loading capacity and release profile. Nanoparticles were formed by ionotropic complexation and coacervation between polyanions (dextran sulfate and alginate) and chitosan. Diameter was evaluated with photon correlation spectroscopy, polymer interaction was confirmed by DSC and FTIR and particle morphology was assessed by SEM and TEM. Mean nanoparticle diameter ranged from 423 to 850 nm, insulin association efficiency from 63 to 94% and loading capacity from 5 to 13%. Dextran sulfate provided highest insulin association efficiency and retention of insulin in gastric simulated conditions. These nanoparticle systems show promise as insulin and potentially other therapeutic polypeptides carriers.
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/7958
http://hdl.handle.net/10316/7958
https://doi.org/10.1007/s10989-005-9010-3
url http://hdl.handle.net/10316/7958
https://doi.org/10.1007/s10989-005-9010-3
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Peptide Research and Therapeutics. 12:2 (2006) 131-138
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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