Metabolic interactions in asthma

Detalhes bibliográficos
Autor(a) principal: Farraia, M
Data de Publicação: 2019
Outros Autores: Cavaleiro Rufo, J, Paciência, I, Castro Mendes, F, Delgado, L, Laerte Boechat, J, Moreira, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/154291
Resumo: Metabolomics can be used to explore altered metabolic pathways in asthma, giving insights into its pathophysiology. We aimed to review how metabolomics has been used to understand asthma by describing metabolic pathways under research and discussing clinical implications. The search was performed in PubMed, and studies published since 2000 using a metabolomics approach, were included. A total of 32 studies were analysed. Pathways related with cellular energy homeostasis, lipid metabolism and oxidative stress, immune and inflammatory processes and others were altered. Initial studies focused on biomarker discovery. But, metabolomics can be used to evaluate drug effects on specific pathways, to highlight pathways that can further develop in new targeted treatments and to identify differences according to asthma severity and phenotypes.
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spelling Metabolic interactions in asthmaMetabolomics can be used to explore altered metabolic pathways in asthma, giving insights into its pathophysiology. We aimed to review how metabolomics has been used to understand asthma by describing metabolic pathways under research and discussing clinical implications. The search was performed in PubMed, and studies published since 2000 using a metabolomics approach, were included. A total of 32 studies were analysed. Pathways related with cellular energy homeostasis, lipid metabolism and oxidative stress, immune and inflammatory processes and others were altered. Initial studies focused on biomarker discovery. But, metabolomics can be used to evaluate drug effects on specific pathways, to highlight pathways that can further develop in new targeted treatments and to identify differences according to asthma severity and phenotypes.EDRA20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/154291eng1764-148910.23822/EurAnnACI.1764-1489.101Farraia, MCavaleiro Rufo, JPaciência, ICastro Mendes, FDelgado, LLaerte Boechat, JMoreira, Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:53:39Zoai:repositorio-aberto.up.pt:10216/154291Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:28:50.622930Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolic interactions in asthma
title Metabolic interactions in asthma
spellingShingle Metabolic interactions in asthma
Farraia, M
title_short Metabolic interactions in asthma
title_full Metabolic interactions in asthma
title_fullStr Metabolic interactions in asthma
title_full_unstemmed Metabolic interactions in asthma
title_sort Metabolic interactions in asthma
author Farraia, M
author_facet Farraia, M
Cavaleiro Rufo, J
Paciência, I
Castro Mendes, F
Delgado, L
Laerte Boechat, J
Moreira, A
author_role author
author2 Cavaleiro Rufo, J
Paciência, I
Castro Mendes, F
Delgado, L
Laerte Boechat, J
Moreira, A
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Farraia, M
Cavaleiro Rufo, J
Paciência, I
Castro Mendes, F
Delgado, L
Laerte Boechat, J
Moreira, A
description Metabolomics can be used to explore altered metabolic pathways in asthma, giving insights into its pathophysiology. We aimed to review how metabolomics has been used to understand asthma by describing metabolic pathways under research and discussing clinical implications. The search was performed in PubMed, and studies published since 2000 using a metabolomics approach, were included. A total of 32 studies were analysed. Pathways related with cellular energy homeostasis, lipid metabolism and oxidative stress, immune and inflammatory processes and others were altered. Initial studies focused on biomarker discovery. But, metabolomics can be used to evaluate drug effects on specific pathways, to highlight pathways that can further develop in new targeted treatments and to identify differences according to asthma severity and phenotypes.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/154291
url https://hdl.handle.net/10216/154291
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1764-1489
10.23822/EurAnnACI.1764-1489.101
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eu_rights_str_mv openAccess
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