Methadone Intoxication in a Child: Toxic Encephalopathy?

Detalhes bibliográficos
Autor(a) principal: Anselmo, M
Data de Publicação: 2006
Outros Autores: Campos Rainho, A, Vale, MC, Estrada, J, Valente, R, Correia, M, Vieira, JP, Barata, D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2343
Resumo: Methadone is used in the treatment of opioid addiction. Acute intoxication can lead to severe consequences and can even be lethal. In several case reports and small series, a presumably toxic leukoencephalopathy is described resulting from inhalation of heroin. We present the case of a 3-year-old boy who ingested methadone accidentally. In a coma with acute obstructive hydrocephalus owing to massive cerebellar edema and supratentorial lesions, he was successfully treated with methylprednisolone and cerebrospinal fluid external drainage. To our knowledge, this is the first report of an encephalopathy associated with synthetic opioid intoxication.
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spelling Methadone Intoxication in a Child: Toxic Encephalopathy?Analgesics, Opioid/poisoningBrain Diseases/chemically inducedBrain Diseases/pathologyBrain Diseases/therapyMethadone/poisoningNeurotoxicity Syndromes/etiologyNeurotoxicity Syndromes/therapyChild, PreschoolCase ReportsHDE NEU PEDHDE UCI PEDMethadone is used in the treatment of opioid addiction. Acute intoxication can lead to severe consequences and can even be lethal. In several case reports and small series, a presumably toxic leukoencephalopathy is described resulting from inhalation of heroin. We present the case of a 3-year-old boy who ingested methadone accidentally. In a coma with acute obstructive hydrocephalus owing to massive cerebellar edema and supratentorial lesions, he was successfully treated with methylprednisolone and cerebrospinal fluid external drainage. To our knowledge, this is the first report of an encephalopathy associated with synthetic opioid intoxication.Sage PublicationsRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEAnselmo, MCampos Rainho, AVale, MCEstrada, JValente, RCorreia, MVieira, JPBarata, D2015-11-13T11:51:59Z2006-072006-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2343engJ Child Neurol. 2006 Jul;21(7):618-20.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:36:31Zoai:repositorio.chlc.min-saude.pt:10400.17/2343Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:42.281512Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Methadone Intoxication in a Child: Toxic Encephalopathy?
title Methadone Intoxication in a Child: Toxic Encephalopathy?
spellingShingle Methadone Intoxication in a Child: Toxic Encephalopathy?
Anselmo, M
Analgesics, Opioid/poisoning
Brain Diseases/chemically induced
Brain Diseases/pathology
Brain Diseases/therapy
Methadone/poisoning
Neurotoxicity Syndromes/etiology
Neurotoxicity Syndromes/therapy
Child, Preschool
Case Reports
HDE NEU PED
HDE UCI PED
title_short Methadone Intoxication in a Child: Toxic Encephalopathy?
title_full Methadone Intoxication in a Child: Toxic Encephalopathy?
title_fullStr Methadone Intoxication in a Child: Toxic Encephalopathy?
title_full_unstemmed Methadone Intoxication in a Child: Toxic Encephalopathy?
title_sort Methadone Intoxication in a Child: Toxic Encephalopathy?
author Anselmo, M
author_facet Anselmo, M
Campos Rainho, A
Vale, MC
Estrada, J
Valente, R
Correia, M
Vieira, JP
Barata, D
author_role author
author2 Campos Rainho, A
Vale, MC
Estrada, J
Valente, R
Correia, M
Vieira, JP
Barata, D
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Anselmo, M
Campos Rainho, A
Vale, MC
Estrada, J
Valente, R
Correia, M
Vieira, JP
Barata, D
dc.subject.por.fl_str_mv Analgesics, Opioid/poisoning
Brain Diseases/chemically induced
Brain Diseases/pathology
Brain Diseases/therapy
Methadone/poisoning
Neurotoxicity Syndromes/etiology
Neurotoxicity Syndromes/therapy
Child, Preschool
Case Reports
HDE NEU PED
HDE UCI PED
topic Analgesics, Opioid/poisoning
Brain Diseases/chemically induced
Brain Diseases/pathology
Brain Diseases/therapy
Methadone/poisoning
Neurotoxicity Syndromes/etiology
Neurotoxicity Syndromes/therapy
Child, Preschool
Case Reports
HDE NEU PED
HDE UCI PED
description Methadone is used in the treatment of opioid addiction. Acute intoxication can lead to severe consequences and can even be lethal. In several case reports and small series, a presumably toxic leukoencephalopathy is described resulting from inhalation of heroin. We present the case of a 3-year-old boy who ingested methadone accidentally. In a coma with acute obstructive hydrocephalus owing to massive cerebellar edema and supratentorial lesions, he was successfully treated with methylprednisolone and cerebrospinal fluid external drainage. To our knowledge, this is the first report of an encephalopathy associated with synthetic opioid intoxication.
publishDate 2006
dc.date.none.fl_str_mv 2006-07
2006-07-01T00:00:00Z
2015-11-13T11:51:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2343
url http://hdl.handle.net/10400.17/2343
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Child Neurol. 2006 Jul;21(7):618-20.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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