The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/37547 |
Resumo: | Cyclophosphamide (CP) and Cisplatin (CDDP) are antineoplastic drugs widely used in the treatment of neoplastic diseases that have been detected in the aquatic environment. This review summarizes the current knowledge on the presence in the aquatic environment of these two drugs and their effects on freshwater and marine invertebrates, which includes good model species in ecotoxicology and risk assessment programs. The consumption levels, occurrence in freshwater and marine ecosystems, and the impacts exerted on aquatic organisms, even at low concentrations, justifies this review and the selection of these two drugs. Both pharmaceuticals were detected in different aquatic environments, with concentrations ranging from ng L-1 up to 687.0 μg L-1 (CP) and 250 μg L-1 (CDDP). The available studies showed that CP and CDDP induce individual and sub-individual impacts on aquatic invertebrate species. The most common effects reported were changes in the reproductive function, oxidative stress, genotoxicity, cytotoxicity and neurotoxicity. The literature used in this review supports the need to increase monitoring studies concerning the occurrence of antineoplastic drugs in the aquatic environment since negative effects have been reported even at trace concentrations (ng L-1). Furthermore, marine ecosystems should be considered as a priority since less is known on the occurrence and effects of antineoplastic drugs in this environment comparing to freshwater ecosystems. |
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The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - reviewPharmaceuticalsAnticancer drugsCytotoxic drugsInvertebratesBiological impactsAccumulation levelsCyclophosphamide (CP) and Cisplatin (CDDP) are antineoplastic drugs widely used in the treatment of neoplastic diseases that have been detected in the aquatic environment. This review summarizes the current knowledge on the presence in the aquatic environment of these two drugs and their effects on freshwater and marine invertebrates, which includes good model species in ecotoxicology and risk assessment programs. The consumption levels, occurrence in freshwater and marine ecosystems, and the impacts exerted on aquatic organisms, even at low concentrations, justifies this review and the selection of these two drugs. Both pharmaceuticals were detected in different aquatic environments, with concentrations ranging from ng L-1 up to 687.0 μg L-1 (CP) and 250 μg L-1 (CDDP). The available studies showed that CP and CDDP induce individual and sub-individual impacts on aquatic invertebrate species. The most common effects reported were changes in the reproductive function, oxidative stress, genotoxicity, cytotoxicity and neurotoxicity. The literature used in this review supports the need to increase monitoring studies concerning the occurrence of antineoplastic drugs in the aquatic environment since negative effects have been reported even at trace concentrations (ng L-1). Furthermore, marine ecosystems should be considered as a priority since less is known on the occurrence and effects of antineoplastic drugs in this environment comparing to freshwater ecosystems.Elsevier2023-06-15T00:00:00Z2021-06-15T00:00:00Z2021-06-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37547eng0304-389410.1016/j.jhazmat.2020.125028Queirós, VanessaAzeiteiro, Ulisses M.Soares, Amadeu M. V. M.Freitas, Rosainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:12:37Zoai:ria.ua.pt:10773/37547Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:08:10.050797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
title |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
spellingShingle |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review Queirós, Vanessa Pharmaceuticals Anticancer drugs Cytotoxic drugs Invertebrates Biological impacts Accumulation levels |
title_short |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
title_full |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
title_fullStr |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
title_full_unstemmed |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
title_sort |
The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment - review |
author |
Queirós, Vanessa |
author_facet |
Queirós, Vanessa Azeiteiro, Ulisses M. Soares, Amadeu M. V. M. Freitas, Rosa |
author_role |
author |
author2 |
Azeiteiro, Ulisses M. Soares, Amadeu M. V. M. Freitas, Rosa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Queirós, Vanessa Azeiteiro, Ulisses M. Soares, Amadeu M. V. M. Freitas, Rosa |
dc.subject.por.fl_str_mv |
Pharmaceuticals Anticancer drugs Cytotoxic drugs Invertebrates Biological impacts Accumulation levels |
topic |
Pharmaceuticals Anticancer drugs Cytotoxic drugs Invertebrates Biological impacts Accumulation levels |
description |
Cyclophosphamide (CP) and Cisplatin (CDDP) are antineoplastic drugs widely used in the treatment of neoplastic diseases that have been detected in the aquatic environment. This review summarizes the current knowledge on the presence in the aquatic environment of these two drugs and their effects on freshwater and marine invertebrates, which includes good model species in ecotoxicology and risk assessment programs. The consumption levels, occurrence in freshwater and marine ecosystems, and the impacts exerted on aquatic organisms, even at low concentrations, justifies this review and the selection of these two drugs. Both pharmaceuticals were detected in different aquatic environments, with concentrations ranging from ng L-1 up to 687.0 μg L-1 (CP) and 250 μg L-1 (CDDP). The available studies showed that CP and CDDP induce individual and sub-individual impacts on aquatic invertebrate species. The most common effects reported were changes in the reproductive function, oxidative stress, genotoxicity, cytotoxicity and neurotoxicity. The literature used in this review supports the need to increase monitoring studies concerning the occurrence of antineoplastic drugs in the aquatic environment since negative effects have been reported even at trace concentrations (ng L-1). Furthermore, marine ecosystems should be considered as a priority since less is known on the occurrence and effects of antineoplastic drugs in this environment comparing to freshwater ecosystems. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-15T00:00:00Z 2021-06-15 2023-06-15T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/37547 |
url |
http://hdl.handle.net/10773/37547 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0304-3894 10.1016/j.jhazmat.2020.125028 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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