Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/1607 |
Resumo: | Antiphospholipid syndrome is a relatively recent systemic autoimmune disorder defined by thrombotic events and/or obstetric complications in the presence of persistent elevated antiphospholipid antibodies. It is characterized by a wide spectrum of clinical presentations and virtually any organ system or tissue may be affected by the consequences of vascular occlusion. Diagnosis is sometimes difficult and although classification criteria have been published and revised there remain ongoing issues regarding nomenclature, expanding clinical features, laboratory tests and management and much still has to be done. Cutaneous manifestations are common and frequently the first sign of the disease. Although extremely diverse it’s important to know which dermatological findings should prompt consideration of antiphospholipid syndrome and the appropriate management for those patients. Much has been debated about when to consider antiphospholipid syndrome and consensus still does not exist, however in spite of being a diagnostic challenge clinicians should know when to look for antiphospholipid antibodies since an early diagnosis is important to prevent further and serious complications. In this article we focus on the cutaneous features that should raise suspicion on the presence of antiphospholipid syndrome and on the complex management of such patients. Many other dermatological signs related to this syndrome have been described in the literature but only occasionally and without consistency or statistic impact and therefore will not be considered here |
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Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and managementAntiphospholipid SyndromeSkinDermatologyReviewDiagnosisAntiphospholipid syndrome is a relatively recent systemic autoimmune disorder defined by thrombotic events and/or obstetric complications in the presence of persistent elevated antiphospholipid antibodies. It is characterized by a wide spectrum of clinical presentations and virtually any organ system or tissue may be affected by the consequences of vascular occlusion. Diagnosis is sometimes difficult and although classification criteria have been published and revised there remain ongoing issues regarding nomenclature, expanding clinical features, laboratory tests and management and much still has to be done. Cutaneous manifestations are common and frequently the first sign of the disease. Although extremely diverse it’s important to know which dermatological findings should prompt consideration of antiphospholipid syndrome and the appropriate management for those patients. Much has been debated about when to consider antiphospholipid syndrome and consensus still does not exist, however in spite of being a diagnostic challenge clinicians should know when to look for antiphospholipid antibodies since an early diagnosis is important to prevent further and serious complications. In this article we focus on the cutaneous features that should raise suspicion on the presence of antiphospholipid syndrome and on the complex management of such patients. Many other dermatological signs related to this syndrome have been described in the literature but only occasionally and without consistency or statistic impact and therefore will not be considered hereO síndrome antifosfolipidico é uma patologia auto-imune relativamente recente definida por eventos trombóticos e/ou complicações obstétricas na presença de anticorpos antifosfolípido elevados persistentes. Caracteriza-se por um vasto leque de apresentações clínicas e virtualmente qualquer sistema orgânico ou tecido pode ser afectado por oclusão vascular. O diagnóstico é por vezes difícil e, apesar de critérios de classificação terem sido publicados e revistos, muitas dúvidas persistem relativamente à nomenclatura, características clínicas, testes laboratoriais e abordagem destes doentes. As manifestações cutâneas são comuns e, frequentemente, o primeiro sinal da doença. Apesar da grande variabilidade, é importante reconhecer os achados dermatológicos que devem levantar a suspeita de um síndrome antifosfolipidico, assim como a abordagem adequada destes doentes. Muito tem sido debatido sobre quando considerar o diagnóstico desta entidade, não havendo ainda consenso neste assunto; no entanto, apesar de ser um desafio diagnóstico, é importante saber quando investigar a presença de anticorpos antifosfolípidos, uma vez que um diagnóstico precoce é crucial para prevenir complicações futuras graves. No presente artigo os autores descrevem as manifestações dermatológicas que devem fazer considerar o diagnóstico com enfoque na abordagem complexa destes doentes. Têm sido descritas na literatura muitas outras alterações cutâneas relacionadas com esta entidade, no entanto, apenas de forma ocasional e sem consistência ou impacto estatístico, pelo que não serão consideradas.Sociedade Portuguesa de ReumatologiaRepositório Científico do Centro Hospitalar Universitário de Santo AntónioPinto-Almeida, T.Caetano, M.Sanches, M.Selores, M.2014-06-02T14:37:30Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1607engACTA REUMATOL PORT. 2013;38:10-180303-464Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:56:43Zoai:repositorio.chporto.pt:10400.16/1607Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:37:59.895055Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
title |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
spellingShingle |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management Pinto-Almeida, T. Antiphospholipid Syndrome Skin Dermatology Review Diagnosis |
title_short |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
title_full |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
title_fullStr |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
title_full_unstemmed |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
title_sort |
Cutaneous manifestations of antiphospholipid syndrome: a review of the clinical features, diagnosis and management |
author |
Pinto-Almeida, T. |
author_facet |
Pinto-Almeida, T. Caetano, M. Sanches, M. Selores, M. |
author_role |
author |
author2 |
Caetano, M. Sanches, M. Selores, M. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Pinto-Almeida, T. Caetano, M. Sanches, M. Selores, M. |
dc.subject.por.fl_str_mv |
Antiphospholipid Syndrome Skin Dermatology Review Diagnosis |
topic |
Antiphospholipid Syndrome Skin Dermatology Review Diagnosis |
description |
Antiphospholipid syndrome is a relatively recent systemic autoimmune disorder defined by thrombotic events and/or obstetric complications in the presence of persistent elevated antiphospholipid antibodies. It is characterized by a wide spectrum of clinical presentations and virtually any organ system or tissue may be affected by the consequences of vascular occlusion. Diagnosis is sometimes difficult and although classification criteria have been published and revised there remain ongoing issues regarding nomenclature, expanding clinical features, laboratory tests and management and much still has to be done. Cutaneous manifestations are common and frequently the first sign of the disease. Although extremely diverse it’s important to know which dermatological findings should prompt consideration of antiphospholipid syndrome and the appropriate management for those patients. Much has been debated about when to consider antiphospholipid syndrome and consensus still does not exist, however in spite of being a diagnostic challenge clinicians should know when to look for antiphospholipid antibodies since an early diagnosis is important to prevent further and serious complications. In this article we focus on the cutaneous features that should raise suspicion on the presence of antiphospholipid syndrome and on the complex management of such patients. Many other dermatological signs related to this syndrome have been described in the literature but only occasionally and without consistency or statistic impact and therefore will not be considered here |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2014-06-02T14:37:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/1607 |
url |
http://hdl.handle.net/10400.16/1607 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ACTA REUMATOL PORT. 2013;38:10-18 0303-464X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Reumatologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Reumatologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133641990733824 |