Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/154109 |
Resumo: | Objective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (−0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants. |
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spelling |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysisObjective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (−0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants.BMJ Publishing Group20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/154109eng1759-21510959-813810.1136/bmj-2023-075203Liu, CChen, RSera, FVicedo-Cabrera, AMGuo, YTong, SLavigne, ECorrea, PMOrtega, NVAchilleos, SRoye, DJaakkola, JJRyti, NPascal, MSchneider, ABreitner, SEntezari, AMayvaneh, FRaz, RHonda, YHashizume, MNg, CFSGaio, VMadureira, JHolobaca, IHTobias, AÍñiguez, CGuo, YLPan, SCMasselot, PBell, MLZanobetti, ASchwartz, JGasparrini, AKan, Hinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:58:58Zoai:repositorio-aberto.up.pt:10216/154109Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:12:57.874606Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
spellingShingle |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis Liu, C |
title_short |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_full |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_fullStr |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_full_unstemmed |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_sort |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
author |
Liu, C |
author_facet |
Liu, C Chen, R Sera, F Vicedo-Cabrera, AM Guo, Y Tong, S Lavigne, E Correa, PM Ortega, NV Achilleos, S Roye, D Jaakkola, JJ Ryti, N Pascal, M Schneider, A Breitner, S Entezari, A Mayvaneh, F Raz, R Honda, Y Hashizume, M Ng, CFS Gaio, V Madureira, J Holobaca, IH Tobias, A Íñiguez, C Guo, YL Pan, SC Masselot, P Bell, ML Zanobetti, A Schwartz, J Gasparrini, A Kan, H |
author_role |
author |
author2 |
Chen, R Sera, F Vicedo-Cabrera, AM Guo, Y Tong, S Lavigne, E Correa, PM Ortega, NV Achilleos, S Roye, D Jaakkola, JJ Ryti, N Pascal, M Schneider, A Breitner, S Entezari, A Mayvaneh, F Raz, R Honda, Y Hashizume, M Ng, CFS Gaio, V Madureira, J Holobaca, IH Tobias, A Íñiguez, C Guo, YL Pan, SC Masselot, P Bell, ML Zanobetti, A Schwartz, J Gasparrini, A Kan, H |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Liu, C Chen, R Sera, F Vicedo-Cabrera, AM Guo, Y Tong, S Lavigne, E Correa, PM Ortega, NV Achilleos, S Roye, D Jaakkola, JJ Ryti, N Pascal, M Schneider, A Breitner, S Entezari, A Mayvaneh, F Raz, R Honda, Y Hashizume, M Ng, CFS Gaio, V Madureira, J Holobaca, IH Tobias, A Íñiguez, C Guo, YL Pan, SC Masselot, P Bell, ML Zanobetti, A Schwartz, J Gasparrini, A Kan, H |
description |
Objective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (−0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/154109 |
url |
https://hdl.handle.net/10216/154109 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1759-2151 0959-8138 10.1136/bmj-2023-075203 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
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BMJ Publishing Group |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136052343996416 |