Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis

Detalhes bibliográficos
Autor(a) principal: Liu, C
Data de Publicação: 2023
Outros Autores: Chen, R, Sera, F, Vicedo-Cabrera, AM, Guo, Y, Tong, S, Lavigne, E, Correa, PM, Ortega, NV, Achilleos, S, Roye, D, Jaakkola, JJ, Ryti, N, Pascal, M, Schneider, A, Breitner, S, Entezari, A, Mayvaneh, F, Raz, R, Honda, Y, Hashizume, M, Ng, CFS, Gaio, V, Madureira, J, Holobaca, IH, Tobias, A, Íñiguez, C, Guo, YL, Pan, SC, Masselot, P, Bell, ML, Zanobetti, A, Schwartz, J, Gasparrini, A, Kan, H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/154109
Resumo: Objective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (−0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants.
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spelling Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysisObjective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (−0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants.BMJ Publishing Group20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/154109eng1759-21510959-813810.1136/bmj-2023-075203Liu, CChen, RSera, FVicedo-Cabrera, AMGuo, YTong, SLavigne, ECorrea, PMOrtega, NVAchilleos, SRoye, DJaakkola, JJRyti, NPascal, MSchneider, ABreitner, SEntezari, AMayvaneh, FRaz, RHonda, YHashizume, MNg, CFSGaio, VMadureira, JHolobaca, IHTobias, AÍñiguez, CGuo, YLPan, SCMasselot, PBell, MLZanobetti, ASchwartz, JGasparrini, AKan, Hinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:58:58Zoai:repositorio-aberto.up.pt:10216/154109Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:12:57.874606Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
title Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
spellingShingle Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
Liu, C
title_short Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
title_full Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
title_fullStr Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
title_full_unstemmed Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
title_sort Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
author Liu, C
author_facet Liu, C
Chen, R
Sera, F
Vicedo-Cabrera, AM
Guo, Y
Tong, S
Lavigne, E
Correa, PM
Ortega, NV
Achilleos, S
Roye, D
Jaakkola, JJ
Ryti, N
Pascal, M
Schneider, A
Breitner, S
Entezari, A
Mayvaneh, F
Raz, R
Honda, Y
Hashizume, M
Ng, CFS
Gaio, V
Madureira, J
Holobaca, IH
Tobias, A
Íñiguez, C
Guo, YL
Pan, SC
Masselot, P
Bell, ML
Zanobetti, A
Schwartz, J
Gasparrini, A
Kan, H
author_role author
author2 Chen, R
Sera, F
Vicedo-Cabrera, AM
Guo, Y
Tong, S
Lavigne, E
Correa, PM
Ortega, NV
Achilleos, S
Roye, D
Jaakkola, JJ
Ryti, N
Pascal, M
Schneider, A
Breitner, S
Entezari, A
Mayvaneh, F
Raz, R
Honda, Y
Hashizume, M
Ng, CFS
Gaio, V
Madureira, J
Holobaca, IH
Tobias, A
Íñiguez, C
Guo, YL
Pan, SC
Masselot, P
Bell, ML
Zanobetti, A
Schwartz, J
Gasparrini, A
Kan, H
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Liu, C
Chen, R
Sera, F
Vicedo-Cabrera, AM
Guo, Y
Tong, S
Lavigne, E
Correa, PM
Ortega, NV
Achilleos, S
Roye, D
Jaakkola, JJ
Ryti, N
Pascal, M
Schneider, A
Breitner, S
Entezari, A
Mayvaneh, F
Raz, R
Honda, Y
Hashizume, M
Ng, CFS
Gaio, V
Madureira, J
Holobaca, IH
Tobias, A
Íñiguez, C
Guo, YL
Pan, SC
Masselot, P
Bell, ML
Zanobetti, A
Schwartz, J
Gasparrini, A
Kan, H
description Objective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (−0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url https://hdl.handle.net/10216/154109
dc.language.iso.fl_str_mv eng
language eng
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0959-8138
10.1136/bmj-2023-075203
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