QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils

Detalhes bibliográficos
Autor(a) principal: Bragança, Idalina
Data de Publicação: 2012
Outros Autores: Plácido, Alexandra, Paíga, Paula, Domingues, Valentina F., Delerue-Matos, Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/2050
Resumo: Ibuprofen is one of the most used active pharmaceutical ingredients worldwide. A new method for the analysis of ibuprofen and its metabolites, hydroxyibuprofen and carboxyibuprofen, in soils is presented. The extraction of these compounds from the soil matrices was performed by using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The method involves a single extraction of the investigated compounds with purified water (acidified at pH 2.5 with hydrochloric acid), and a slow and continuous addition of the QuEChERS content, followed by the addition of acidified acetonitrile (1% acetic acid), prior to the determination by liquid chromatography coupled with fluorescence detection (LC–FLD). Validation studies were carried out using soil samples with a range of organic carbon contents. Recoveries of the fortified samples ranged from 79.5% to 101%. Relative standard deviations for all matrix–compound combinations did not exceed 3%. The method quantification limits were ≤22.4 μg kg−1 in all cases. The developed method was applied to the analysis of sixteen real samples.
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spelling QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soilsIbuprofenMetabolitesQuEChERSSoilExtractionIbuprofen is one of the most used active pharmaceutical ingredients worldwide. A new method for the analysis of ibuprofen and its metabolites, hydroxyibuprofen and carboxyibuprofen, in soils is presented. The extraction of these compounds from the soil matrices was performed by using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The method involves a single extraction of the investigated compounds with purified water (acidified at pH 2.5 with hydrochloric acid), and a slow and continuous addition of the QuEChERS content, followed by the addition of acidified acetonitrile (1% acetic acid), prior to the determination by liquid chromatography coupled with fluorescence detection (LC–FLD). Validation studies were carried out using soil samples with a range of organic carbon contents. Recoveries of the fortified samples ranged from 79.5% to 101%. Relative standard deviations for all matrix–compound combinations did not exceed 3%. The method quantification limits were ≤22.4 μg kg−1 in all cases. The developed method was applied to the analysis of sixteen real samples.ElsevierRepositório Científico do Instituto Politécnico do PortoBragança, IdalinaPlácido, AlexandraPaíga, PaulaDomingues, Valentina F.Delerue-Matos, Cristina2013-10-01T11:08:18Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/2050eng0048-969710.1016/j.scitotenv.2012.06.035metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:41:34Zoai:recipp.ipp.pt:10400.22/2050Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:23:09.335474Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
title QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
spellingShingle QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
Bragança, Idalina
Ibuprofen
Metabolites
QuEChERS
Soil
Extraction
title_short QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
title_full QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
title_fullStr QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
title_full_unstemmed QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
title_sort QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils
author Bragança, Idalina
author_facet Bragança, Idalina
Plácido, Alexandra
Paíga, Paula
Domingues, Valentina F.
Delerue-Matos, Cristina
author_role author
author2 Plácido, Alexandra
Paíga, Paula
Domingues, Valentina F.
Delerue-Matos, Cristina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Bragança, Idalina
Plácido, Alexandra
Paíga, Paula
Domingues, Valentina F.
Delerue-Matos, Cristina
dc.subject.por.fl_str_mv Ibuprofen
Metabolites
QuEChERS
Soil
Extraction
topic Ibuprofen
Metabolites
QuEChERS
Soil
Extraction
description Ibuprofen is one of the most used active pharmaceutical ingredients worldwide. A new method for the analysis of ibuprofen and its metabolites, hydroxyibuprofen and carboxyibuprofen, in soils is presented. The extraction of these compounds from the soil matrices was performed by using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The method involves a single extraction of the investigated compounds with purified water (acidified at pH 2.5 with hydrochloric acid), and a slow and continuous addition of the QuEChERS content, followed by the addition of acidified acetonitrile (1% acetic acid), prior to the determination by liquid chromatography coupled with fluorescence detection (LC–FLD). Validation studies were carried out using soil samples with a range of organic carbon contents. Recoveries of the fortified samples ranged from 79.5% to 101%. Relative standard deviations for all matrix–compound combinations did not exceed 3%. The method quantification limits were ≤22.4 μg kg−1 in all cases. The developed method was applied to the analysis of sixteen real samples.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2013-10-01T11:08:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/2050
url http://hdl.handle.net/10400.22/2050
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0048-9697
10.1016/j.scitotenv.2012.06.035
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rights_invalid_str_mv metadata only access
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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