The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95080 https://doi.org/10.1016/j.bbadis.2020.165834 |
Resumo: | Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca2+ flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. In the present review, we summarize the current understanding of basic MAM biology, composition and function and discuss the possible role of MAM-resident oncogenes and tumor suppressors. |
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The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspectiveCancer; Endoplasmic reticulum; Mitochondria; Mitochondria-associated membranes (MAM); Oncogenes; OncosuppressorsAutophagyCalcium SignalingEndoplasmic ReticulumHomeostasisHumansLipid MetabolismMitochondriaMitochondrial MembranesNeoplasmsProtein TransportReactive Oxygen SpeciesMitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca2+ flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. In the present review, we summarize the current understanding of basic MAM biology, composition and function and discuss the possible role of MAM-resident oncogenes and tumor suppressors.2020-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/95080http://hdl.handle.net/10316/95080https://doi.org/10.1016/j.bbadis.2020.165834eng09254439https://www.sciencedirect.com/science/article/abs/pii/S0925443920301794Simoes, Ines C MMorciano, GiampaoloLebiedzinska-Arciszewska, MagdalenaAguiari, GianlucaPinton, PaoloPotes, YaizaWieckowski, Mariusz R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-07-12T08:42:54Zoai:estudogeral.uc.pt:10316/95080Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:39.837131Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
title |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
spellingShingle |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective Simoes, Ines C M Cancer; Endoplasmic reticulum; Mitochondria; Mitochondria-associated membranes (MAM); Oncogenes; Oncosuppressors Autophagy Calcium Signaling Endoplasmic Reticulum Homeostasis Humans Lipid Metabolism Mitochondria Mitochondrial Membranes Neoplasms Protein Transport Reactive Oxygen Species |
title_short |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
title_full |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
title_fullStr |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
title_full_unstemmed |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
title_sort |
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective |
author |
Simoes, Ines C M |
author_facet |
Simoes, Ines C M Morciano, Giampaolo Lebiedzinska-Arciszewska, Magdalena Aguiari, Gianluca Pinton, Paolo Potes, Yaiza Wieckowski, Mariusz R. |
author_role |
author |
author2 |
Morciano, Giampaolo Lebiedzinska-Arciszewska, Magdalena Aguiari, Gianluca Pinton, Paolo Potes, Yaiza Wieckowski, Mariusz R. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Simoes, Ines C M Morciano, Giampaolo Lebiedzinska-Arciszewska, Magdalena Aguiari, Gianluca Pinton, Paolo Potes, Yaiza Wieckowski, Mariusz R. |
dc.subject.por.fl_str_mv |
Cancer; Endoplasmic reticulum; Mitochondria; Mitochondria-associated membranes (MAM); Oncogenes; Oncosuppressors Autophagy Calcium Signaling Endoplasmic Reticulum Homeostasis Humans Lipid Metabolism Mitochondria Mitochondrial Membranes Neoplasms Protein Transport Reactive Oxygen Species |
topic |
Cancer; Endoplasmic reticulum; Mitochondria; Mitochondria-associated membranes (MAM); Oncogenes; Oncosuppressors Autophagy Calcium Signaling Endoplasmic Reticulum Homeostasis Humans Lipid Metabolism Mitochondria Mitochondrial Membranes Neoplasms Protein Transport Reactive Oxygen Species |
description |
Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca2+) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca2+ flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. In the present review, we summarize the current understanding of basic MAM biology, composition and function and discuss the possible role of MAM-resident oncogenes and tumor suppressors. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95080 http://hdl.handle.net/10316/95080 https://doi.org/10.1016/j.bbadis.2020.165834 |
url |
http://hdl.handle.net/10316/95080 https://doi.org/10.1016/j.bbadis.2020.165834 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
09254439 https://www.sciencedirect.com/science/article/abs/pii/S0925443920301794 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134032322101248 |